Gene description for P2RX5
Gene name purinergic receptor P2X, ligand gated ion channel, 5
Gene symbol P2RX5
Other names/aliases LRH-1
P2X5
P2X5R
Species Homo sapiens
 Database cross references - P2RX5
ExoCarta ExoCarta_5026
Entrez Gene 5026
HGNC 8536
MIM 602836
UniProt Q93086  
 P2RX5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for P2RX5
Molecular Function
    ion channel activity GO:0005216 TAS
    transmembrane signaling receptor activity GO:0004888 TAS
    purinergic nucleotide receptor activity GO:0001614 NAS
    ATP binding GO:0005524 NAS
    extracellular ATP-gated cation channel activity GO:0004931 NAS
Biological Process
    response to ATP GO:0033198 IEA
    positive regulation of calcium ion transport into cytosol GO:0010524 NAS
    nervous system development GO:0007399 TAS
    positive regulation of calcium-mediated signaling GO:0050850 NAS
    transport GO:0006810 TAS
    ion transmembrane transport GO:0034220 IBA
    purinergic nucleotide receptor signaling pathway GO:0035590 NAS
    cation transport GO:0006812 IBA
    signal transduction GO:0007165 TAS
    cation transmembrane transport GO:0098655 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
Subcellular Localization
    integral component of nuclear inner membrane GO:0005639 IBA
    integral component of plasma membrane GO:0005887 IEA
 Experiment description of studies that identified P2RX5 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RX5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which P2RX5 is involved
No pathways found





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