Gene description for BRAT1
Gene name BRCA1-associated ATM activator 1
Gene symbol BRAT1
Other names/aliases BAAT1
C7orf27
RMFSL
Species Homo sapiens
 Database cross references - BRAT1
ExoCarta ExoCarta_221927
Vesiclepedia VP_221927
Entrez Gene 221927
HGNC 21701
MIM 614506
UniProt Q6PJG6  
 BRAT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for BRAT1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein phosphorylation GO:0001934 IMP
    glucose metabolic process GO:0006006 IMP
    apoptotic process GO:0006915 IMP
    DNA damage response GO:0006974 IBA
    DNA damage response GO:0006974 IMP
    cell population proliferation GO:0008283 IMP
    response to ionizing radiation GO:0010212 IMP
    cell migration GO:0016477 IMP
    positive regulation of cell growth GO:0030307 IMP
    mitochondrion localization GO:0051646 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified BRAT1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BRAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 F2RL1  
Affinity Capture-MS Homo sapiens
3 SLC35G1  
Affinity Capture-MS Homo sapiens
4 ENKD1  
Two-hybrid Homo sapiens
5 LYPD3 27076
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 USP48  
Co-fractionation Homo sapiens
8 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ST8SIA1  
Affinity Capture-MS Homo sapiens
10 KLK15  
Affinity Capture-MS Homo sapiens
11 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NPRL2  
Affinity Capture-MS Homo sapiens
13 USHBP1  
Two-hybrid Homo sapiens
14 PSG11  
Affinity Capture-MS Homo sapiens
15 FXYD3 5349
Affinity Capture-MS Homo sapiens
16 GPR17 2840
Affinity Capture-MS Homo sapiens
17 NMI  
Two-hybrid Homo sapiens
18 RIN3  
Affinity Capture-MS Homo sapiens
19 HCST  
Affinity Capture-MS Homo sapiens
20 MFSD4  
Affinity Capture-MS Homo sapiens
21 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CYB5B 80777
Affinity Capture-MS Homo sapiens
23 NPTN 27020
Affinity Capture-MS Homo sapiens
24 PTH2R  
Affinity Capture-MS Homo sapiens
25 CD70 970
Affinity Capture-MS Homo sapiens
26 GPR182  
Affinity Capture-MS Homo sapiens
27 BRCA1 672
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
28 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CUL3 8452
Affinity Capture-MS Homo sapiens
30 FPR1  
Affinity Capture-MS Homo sapiens
31 PLBD1 79887
Affinity Capture-MS Homo sapiens
32 NPAS1  
Affinity Capture-MS Homo sapiens
33 ATM 472
Affinity Capture-Western Homo sapiens
34 FXYD6  
Affinity Capture-MS Homo sapiens
35 RPTOR 57521
Affinity Capture-Western Homo sapiens
36 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 METTL21B  
Affinity Capture-MS Homo sapiens
38 P2RY8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PSMD7 5713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TMEM108  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
42 INTS9 55756
Affinity Capture-MS Homo sapiens
43 CD80 941
Affinity Capture-MS Homo sapiens
44 GSTM3 2947
Affinity Capture-MS Homo sapiens
45 FANCA  
Affinity Capture-Luminescence Homo sapiens
46 COMTD1 118881
Affinity Capture-MS Homo sapiens
47 SLC2A1 6513
Affinity Capture-MS Homo sapiens
48 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 HTR2C  
Affinity Capture-MS Homo sapiens
50 INF2 64423
Affinity Capture-MS Homo sapiens
51 VCP 7415
Affinity Capture-MS Homo sapiens
52 MSGN1  
Two-hybrid Homo sapiens
53 NTRK1 4914
Affinity Capture-MS Homo sapiens
54 GPR45  
Affinity Capture-MS Homo sapiens
55 MTOR 2475
Affinity Capture-Western Homo sapiens
56 NCBP1 4686
Affinity Capture-MS Homo sapiens
57 PPARD  
Affinity Capture-MS Homo sapiens
58 FAM96A  
Affinity Capture-MS Homo sapiens
59 P2RX5 5026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SERBP1 26135
Affinity Capture-MS Homo sapiens
61 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 MAS1  
Affinity Capture-MS Homo sapiens
63 PARP1 142
Proximity Label-MS Homo sapiens
64 NXPH3  
Affinity Capture-MS Homo sapiens
65 P2RY10  
Affinity Capture-MS Homo sapiens
66 AR 367
Affinity Capture-MS Homo sapiens
67 GNAI2 2771
Affinity Capture-MS Homo sapiens
68 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 DDX58 23586
Affinity Capture-RNA Homo sapiens
70 RFXANK  
Affinity Capture-MS Homo sapiens
71 PML 5371
Affinity Capture-MS Homo sapiens
72 PHF8  
Affinity Capture-MS Homo sapiens
73 DNAI2  
Affinity Capture-MS Homo sapiens
74 FFAR1  
Affinity Capture-MS Homo sapiens
75 GPR55  
Affinity Capture-MS Homo sapiens
76 Nipbl  
Affinity Capture-MS Mus musculus
77 UBXN6 80700
Affinity Capture-MS Homo sapiens
78 CD274 29126
Affinity Capture-MS Homo sapiens
79 AVPR2  
Affinity Capture-MS Homo sapiens
80 C9orf72  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BRAT1 is involved
No pathways found





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