Gene description for GPR17
Gene name G protein-coupled receptor 17
Gene symbol GPR17
Other names/aliases -
Species Homo sapiens
 Database cross references - GPR17
ExoCarta ExoCarta_2840
Vesiclepedia VP_2840
Entrez Gene 2840
HGNC 4471
MIM 603071
UniProt Q13304  
 GPR17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GPR17
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    chemokine receptor activity GO:0004950 TAS
    protein binding GO:0005515 IPI
    receptor serine/threonine kinase binding GO:0033612 IEA
Biological Process
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    oligodendrocyte differentiation GO:0048709 IEA
    chemokine-mediated signaling pathway GO:0070098 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified GPR17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GPR17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Affinity Capture-Luminescence Homo sapiens
2 TMEM164  
Affinity Capture-MS Homo sapiens
3 HMOX1 3162
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 RANBP6 26953
Affinity Capture-MS Homo sapiens
6 CMTM6 54918
Affinity Capture-MS Homo sapiens
7 TMCO1 54499
Affinity Capture-MS Homo sapiens
8 HOOK1  
Affinity Capture-MS Homo sapiens
9 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
10 NAA25 80018
Affinity Capture-MS Homo sapiens
11 TSPAN15 23555
Affinity Capture-MS Homo sapiens
12 KDELR3 11015
Affinity Capture-MS Homo sapiens
13 TTYH3 80727
Affinity Capture-MS Homo sapiens
14 MMS22L  
Affinity Capture-MS Homo sapiens
15 SLC39A4 55630
Affinity Capture-MS Homo sapiens
16 GJA1 2697
Affinity Capture-MS Homo sapiens
17 CCDC132 55610
Affinity Capture-MS Homo sapiens
18 USP24 23358
Affinity Capture-MS Homo sapiens
19 BZW2 28969
Affinity Capture-MS Homo sapiens
20 EIF2B2 8892
Affinity Capture-MS Homo sapiens
21 CAND2 23066
Affinity Capture-MS Homo sapiens
22 MFN1 55669
Affinity Capture-MS Homo sapiens
23 SLC29A1 2030
Affinity Capture-MS Homo sapiens
24 ATP12A 479
Affinity Capture-MS Homo sapiens
25 NBAS 51594
Affinity Capture-MS Homo sapiens
26 MFSD5  
Affinity Capture-MS Homo sapiens
27 SETX  
Affinity Capture-MS Homo sapiens
28 ATM 472
Affinity Capture-MS Homo sapiens
29 MFSD8 256471
Affinity Capture-MS Homo sapiens
30 COG2 22796
Affinity Capture-MS Homo sapiens
31 INTS1 26173
Affinity Capture-MS Homo sapiens
32 GPD1L 23171
Affinity Capture-MS Homo sapiens
33 HOOK2  
Affinity Capture-MS Homo sapiens
34 LTN1 26046
Affinity Capture-MS Homo sapiens
35 TNFAIP2 7127
Affinity Capture-MS Homo sapiens
36 SETDB1  
Affinity Capture-MS Homo sapiens
37 PRKDC 5591
Affinity Capture-MS Homo sapiens
38 LRP10 26020
Affinity Capture-MS Homo sapiens
39 SLC38A9  
Affinity Capture-MS Homo sapiens
40 DEGS1  
Affinity Capture-MS Homo sapiens
41 FAM126A 84668
Affinity Capture-MS Homo sapiens
42 CD320 51293
Affinity Capture-MS Homo sapiens
43 COG6 57511
Affinity Capture-MS Homo sapiens
44 SLC35F6 54978
Affinity Capture-MS Homo sapiens
45 ALG10  
Affinity Capture-MS Homo sapiens
46 FAM73A  
Affinity Capture-MS Homo sapiens
47 USO1 8615
Affinity Capture-MS Homo sapiens
48 EVI5L  
Affinity Capture-MS Homo sapiens
49 RINT1 60561
Affinity Capture-MS Homo sapiens
50 MDN1 23195
Affinity Capture-MS Homo sapiens
51 ELOVL2  
Affinity Capture-MS Homo sapiens
52 EIF2B4 8890
Affinity Capture-MS Homo sapiens
53 NAV1 89796
Affinity Capture-MS Homo sapiens
54 TMPPE  
Affinity Capture-MS Homo sapiens
55 BRAT1 221927
Affinity Capture-MS Homo sapiens
56 INTS2  
Affinity Capture-MS Homo sapiens
57 NR2F2  
Affinity Capture-MS Homo sapiens
58 UBR3  
Affinity Capture-MS Homo sapiens
59 ERAP1 51752
Affinity Capture-MS Homo sapiens
60 PPP6R1 22870
Affinity Capture-MS Homo sapiens
61 INTS12  
Affinity Capture-MS Homo sapiens
62 TFIP11  
Affinity Capture-MS Homo sapiens
63 KIAA1033 23325
Affinity Capture-MS Homo sapiens
64 XPO7 23039
Affinity Capture-MS Homo sapiens
65 ATP2A3 489
Affinity Capture-MS Homo sapiens
66 IPO8 10526
Affinity Capture-MS Homo sapiens
67 TBC1D15 64786
Affinity Capture-MS Homo sapiens
68 USP33  
Affinity Capture-MS Homo sapiens
69 ARMC6 93436
Affinity Capture-MS Homo sapiens
70 ERMP1 79956
Affinity Capture-MS Homo sapiens
71 SLC25A46 91137
Affinity Capture-MS Homo sapiens
72 ANAPC7 51434
Affinity Capture-MS Homo sapiens
73 UTP20 27340
Affinity Capture-MS Homo sapiens
74 VPS53 55275
Affinity Capture-MS Homo sapiens
75 BTAF1 9044
Affinity Capture-MS Homo sapiens
76 PIGG  
Affinity Capture-MS Homo sapiens
77 MAVS 57506
Affinity Capture-MS Homo sapiens
78 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
79 FPGS 2356
Affinity Capture-MS Homo sapiens
80 COX1 4512
Affinity Capture-MS Homo sapiens
81 EXOC7 23265
Affinity Capture-MS Homo sapiens
82 ADCK4 79934
Affinity Capture-MS Homo sapiens
83 EXOC5 10640
Affinity Capture-MS Homo sapiens
84 TMEM87A 25963
Affinity Capture-MS Homo sapiens
85 DGAT1 8694
Affinity Capture-MS Homo sapiens
86 EXOC3 11336
Affinity Capture-MS Homo sapiens
87 FASTKD1  
Affinity Capture-MS Homo sapiens
88 ATP1A3 478
Affinity Capture-MS Homo sapiens
89 SMEK2  
Affinity Capture-MS Homo sapiens
90 EXOC2 55770
Affinity Capture-MS Homo sapiens
91 WAPAL  
Affinity Capture-MS Homo sapiens
92 HEATR1 55127
Affinity Capture-MS Homo sapiens
93 PDK1 5163
Affinity Capture-MS Homo sapiens
94 ZMYM3  
Affinity Capture-MS Homo sapiens
95 WDFY3 23001
Affinity Capture-MS Homo sapiens
96 VEZT 55591
Affinity Capture-MS Homo sapiens
97 IPO11 51194
Affinity Capture-MS Homo sapiens
98 PLSCR1 5359
Affinity Capture-MS Homo sapiens
99 CDC23 8697
Affinity Capture-MS Homo sapiens
100 TBC1D9B 23061
Affinity Capture-MS Homo sapiens
101 XPO6 23214
Affinity Capture-MS Homo sapiens
102 SAAL1 113174
Affinity Capture-MS Homo sapiens
103 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
104 SLC2A8 29988
Affinity Capture-MS Homo sapiens
105 FADS1 3992
Affinity Capture-MS Homo sapiens
106 TPCN1 53373
Affinity Capture-MS Homo sapiens
107 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
108 XPO5 57510
Affinity Capture-MS Homo sapiens
109 EXOC4 60412
Affinity Capture-MS Homo sapiens
110 HTT 3064
Affinity Capture-MS Homo sapiens
111 RNF213 57674
Affinity Capture-MS Homo sapiens
112 EDA  
Affinity Capture-MS Homo sapiens
113 PDXDC1 23042
Affinity Capture-MS Homo sapiens
114 CHPT1  
Affinity Capture-MS Homo sapiens
115 DDX20 11218
Affinity Capture-MS Homo sapiens
116 DOPEY1  
Affinity Capture-MS Homo sapiens
117 FANCG 2189
Affinity Capture-MS Homo sapiens
118 PDS5A 23244
Affinity Capture-MS Homo sapiens
119 IFRD1 3475
Affinity Capture-MS Homo sapiens
120 ARMC9 80210
Affinity Capture-MS Homo sapiens
121 FAM134A 79137
Affinity Capture-MS Homo sapiens
122 OPA1 4976
Affinity Capture-MS Homo sapiens
123 EXOC6 54536
Affinity Capture-MS Homo sapiens
124 SLC7A2 6542
Affinity Capture-MS Homo sapiens
125 XPOT 11260
Affinity Capture-MS Homo sapiens
126 UBE2Q1 55585
Affinity Capture-MS Homo sapiens
127 LRBA 987
Affinity Capture-MS Homo sapiens
128 CHD1L 9557
Affinity Capture-MS Homo sapiens
129 SLC30A5 64924
Affinity Capture-MS Homo sapiens
130 TNPO2 30000
Affinity Capture-MS Homo sapiens
131 ATP2B4 493
Affinity Capture-MS Homo sapiens
132 LMBR1  
Affinity Capture-MS Homo sapiens
133 ATP6V1H 51606
Affinity Capture-MS Homo sapiens
134 XYLT2 64132
Affinity Capture-MS Homo sapiens
135 TIMELESS  
Affinity Capture-MS Homo sapiens
136 HAUS7  
Affinity Capture-MS Homo sapiens
137 COG4 25839
Affinity Capture-MS Homo sapiens
138 USP28 57646
Affinity Capture-MS Homo sapiens
139 SLC33A1 9197
Affinity Capture-MS Homo sapiens
140 SLC12A9 56996
Affinity Capture-MS Homo sapiens
141 BZW1 9689
Affinity Capture-MS Homo sapiens
142 CAMK1 8536
Affinity Capture-MS Homo sapiens
143 MFSD12  
Affinity Capture-MS Homo sapiens
144 SPPL3  
Affinity Capture-MS Homo sapiens
145 EXOC1 55763
Affinity Capture-MS Homo sapiens
146 TTI1 9675
Affinity Capture-MS Homo sapiens
147 TONSL  
Affinity Capture-MS Homo sapiens
148 PLAA 9373
Affinity Capture-MS Homo sapiens
149 TSPAN3 10099
Affinity Capture-MS Homo sapiens
150 FAM160B1 57700
Affinity Capture-MS Homo sapiens
151 ITPR2 3709
Affinity Capture-MS Homo sapiens
152 SLC4A2 6522
Affinity Capture-MS Homo sapiens
153 FANCD2  
Affinity Capture-MS Homo sapiens
154 TARBP1 6894
Affinity Capture-MS Homo sapiens
155 ATL3 25923
Affinity Capture-MS Homo sapiens
156 KIAA1244  
Affinity Capture-MS Homo sapiens
157 XPO1 7514
Affinity Capture-MS Homo sapiens
158 GLMN 11146
Affinity Capture-MS Homo sapiens
159 RNF170 81790
Affinity Capture-MS Homo sapiens
160 ATR  
Affinity Capture-MS Homo sapiens
161 NCAPH2  
Affinity Capture-MS Homo sapiens
162 TVP23C  
Affinity Capture-MS Homo sapiens
163 C5orf51 285636
Affinity Capture-MS Homo sapiens
164 STK17B 9262
Affinity Capture-MS Homo sapiens
165 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
166 MZT2B 80097
Affinity Capture-MS Homo sapiens
167 FAM114A2  
Affinity Capture-MS Homo sapiens
168 RRAGB 10325
Affinity Capture-MS Homo sapiens
169 FITM2  
Affinity Capture-MS Homo sapiens
170 RMND1 55005
Affinity Capture-MS Homo sapiens
171 TNPO3 23534
Affinity Capture-MS Homo sapiens
172 ATRIP  
Affinity Capture-MS Homo sapiens
173 GBF1 8729
Affinity Capture-MS Homo sapiens
174 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
175 KIAA1524 57650
Affinity Capture-MS Homo sapiens
176 EIF2B3 8891
Affinity Capture-MS Homo sapiens
177 LPCAT3 10162
Affinity Capture-MS Homo sapiens
178 EIF2B5 8893
Affinity Capture-MS Homo sapiens
179 TBCD 6904
Affinity Capture-MS Homo sapiens
180 MSTO1 55154
Affinity Capture-MS Homo sapiens
181 FDFT1 2222
Affinity Capture-MS Homo sapiens
182 HOOK3 84376
Affinity Capture-MS Homo sapiens
183 RADIL  
Affinity Capture-MS Homo sapiens
184 GEMIN4 50628
Affinity Capture-MS Homo sapiens
185 XPO4 64328
Affinity Capture-MS Homo sapiens
186 ALG8  
Affinity Capture-MS Homo sapiens
187 FAM134C 162427
Affinity Capture-MS Homo sapiens
188 PRMT9  
Affinity Capture-MS Homo sapiens
189 NDUFB3 4709
Affinity Capture-MS Homo sapiens
190 PGM3 5238
Affinity Capture-MS Homo sapiens
191 HEATR5B 54497
Affinity Capture-MS Homo sapiens
192 COG8 84342
Affinity Capture-MS Homo sapiens
193 C1orf112  
Affinity Capture-MS Homo sapiens
194 MTOR 2475
Affinity Capture-MS Homo sapiens
195 SLC30A6 55676
Affinity Capture-MS Homo sapiens
196 DOLK 22845
Affinity Capture-MS Homo sapiens
197 MAP3K4 4216
Affinity Capture-MS Homo sapiens
198 COG3 83548
Affinity Capture-MS Homo sapiens
199 PPFIBP1 8496
Affinity Capture-MS Homo sapiens
200 MED23 9439
Affinity Capture-MS Homo sapiens
201 CERS6  
Affinity Capture-MS Homo sapiens
202 LRRC41 10489
Affinity Capture-MS Homo sapiens
203 KIAA0368 23392
Affinity Capture-MS Homo sapiens
204 GPR37  
Two-hybrid Homo sapiens
205 DYM  
Affinity Capture-MS Homo sapiens
206 THADA 63892
Affinity Capture-MS Homo sapiens
207 FAM213A 84293
Affinity Capture-MS Homo sapiens
208 INTS5 80789
Affinity Capture-MS Homo sapiens
209 ADCK1  
Affinity Capture-MS Homo sapiens
210 NCAPG 64151
Affinity Capture-MS Homo sapiens
211 SAYSD1  
Affinity Capture-MS Homo sapiens
212 SACS 26278
Affinity Capture-MS Homo sapiens
213 RAB18 22931
Affinity Capture-MS Homo sapiens
214 LMBRD2 92255
Affinity Capture-MS Homo sapiens
215 GJC1 10052
Affinity Capture-MS Homo sapiens
216 HMGCR  
Affinity Capture-MS Homo sapiens
217 SLC19A2 10560
Affinity Capture-MS Homo sapiens
218 FAM160A2 84067
Affinity Capture-MS Homo sapiens
219 GEMIN2 8487
Affinity Capture-MS Homo sapiens
220 SIMC1  
Affinity Capture-MS Homo sapiens
221 MUL1  
Affinity Capture-MS Homo sapiens
222 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
223 GPR89A  
Affinity Capture-MS Homo sapiens
224 PDS5B 23047
Affinity Capture-MS Homo sapiens
225 ATP13A3 79572
Affinity Capture-MS Homo sapiens
226 ABCB8 11194
Affinity Capture-MS Homo sapiens
227 KNTC1 9735
Affinity Capture-MS Homo sapiens
228 COG1 9382
Affinity Capture-MS Homo sapiens
229 COQ5  
Affinity Capture-MS Homo sapiens
230 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
231 VPS52 6293
Affinity Capture-MS Homo sapiens
232 VAC14 55697
Affinity Capture-MS Homo sapiens
233 DSTYK 25778
Affinity Capture-MS Homo sapiens
234 ATL2 64225
Affinity Capture-MS Homo sapiens
235 RIF1  
Affinity Capture-MS Homo sapiens
236 CLPTM1 1209
Affinity Capture-MS Homo sapiens
237 TMEM120B  
Affinity Capture-MS Homo sapiens
238 COG5 10466
Affinity Capture-MS Homo sapiens
239 DNAAF5 54919
Affinity Capture-MS Homo sapiens
240 URB1 9875
Affinity Capture-MS Homo sapiens
241 CDC6  
Affinity Capture-MS Homo sapiens
242 UBE4A 9354
Affinity Capture-MS Homo sapiens
243 PIK3R4 30849
Affinity Capture-MS Homo sapiens
244 PIGU 128869
Affinity Capture-MS Homo sapiens
245 TSC2 7249
Affinity Capture-MS Homo sapiens
246 EBP  
Affinity Capture-MS Homo sapiens
247 TTK 7272
Affinity Capture-MS Homo sapiens
248 VPS8 23355
Affinity Capture-MS Homo sapiens
249 C19orf25  
Affinity Capture-MS Homo sapiens
250 ATP2A2 488
Affinity Capture-MS Homo sapiens
251 ND4 4538
Affinity Capture-MS Homo sapiens
252 CSE1L 1434
Affinity Capture-MS Homo sapiens
253 ZW10 9183