Gene ontology annotations for SLC4A2
Experiment description of studies that identified SLC4A2 in exosomes
1
Experiment ID
489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 6
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
2
Experiment ID
490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 7
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
3
Experiment ID
491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
4
Experiment ID
492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 9
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
5
Experiment ID
363
MISEV standards
✘
Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
33991177
Organism
Homo sapiens
Experiment description
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors
"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name
Proteomics
Publication year
2021
Sample
Gastric cancer cells
Sample name
MKN1 - 100K pellet
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
6
Experiment ID
364
MISEV standards
✘
Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
33991177
Organism
Homo sapiens
Experiment description
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors
"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name
Proteomics
Publication year
2021
Sample
Gastric cancer cells
Sample name
MKN1 - 100K pellet
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
7
Experiment ID
365
MISEV standards
✘
Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
33991177
Organism
Homo sapiens
Experiment description
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors
"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name
Proteomics
Publication year
2021
Sample
Gastric cancer cells
Sample name
MKN1 - 100K pellet
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
8
Experiment ID
237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocytes
Sample name
MIHA
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RNA Sequencing
9
Experiment ID
211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
10
Experiment ID
212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
11
Experiment ID
275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25844599
Organism
Homo sapiens
Experiment description
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors
"Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name
Oncotarget
Publication year
2015
Sample
Prostate cancer cells
Sample name
DU145 - Docetaxel sensitive
Isolation/purification methods
Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.12-1.19 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry/Flow cytometry/Western blotting
12
Experiment ID
834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
35333565
Organism
Homo sapiens
Experiment description
LAMP2A regulates the loading of proteins into exosomes
Authors
"Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name
Sci Adv
Publication year
2022
Sample
Retinal pigment epithelial cells
Sample name
ARPE-19
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
13
Experiment ID
835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
35333565
Organism
Homo sapiens
Experiment description
LAMP2A regulates the loading of proteins into exosomes
Authors
"Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name
Sci Adv
Publication year
2022
Sample
Retinal pigment epithelial cells
Sample name
ARPE-19
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
Protein-protein interactions for SLC4A2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
STARD3NL
83930
Affinity Capture-MS
Homo sapiens
2
KDELR3
11015
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
3
GJD3
Proximity Label-MS
Homo sapiens
4
CEMIP
57214
Affinity Capture-MS
Homo sapiens
5
Cyr61
Affinity Capture-MS
Mus musculus
6
PTGIR
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
7
OCLN
100506658
Proximity Label-MS
Homo sapiens
8
RXFP1
Affinity Capture-MS
Homo sapiens
9
OR10H2
Affinity Capture-MS
Homo sapiens
10
METTL7A
25840
Proximity Label-MS
Homo sapiens
11
SLC39A4
55630
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
12
LGALS9C
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
13
Iqgap3
404710
Affinity Capture-MS
Mus musculus
14
THOC2
57187
Affinity Capture-MS
Homo sapiens
15
Phospho1
Affinity Capture-MS
Mus musculus
16
LGALS1
3956
Affinity Capture-MS
Homo sapiens
17
HSD17B11
51170
Proximity Label-MS
Homo sapiens
18
GPR114
Affinity Capture-MS
Homo sapiens
19
STX4
6810
Proximity Label-MS
Homo sapiens
20
APEX1
328
Affinity Capture-RNA
Homo sapiens
21
MS4A15
Affinity Capture-MS
Homo sapiens
22
B3GAT1
Proximity Label-MS
Homo sapiens
23
OR6T1
Affinity Capture-MS
Homo sapiens
24
P2RY1
Affinity Capture-MS
Homo sapiens
25
SLC30A2
Affinity Capture-MS
Homo sapiens
26
SIGMAR1
10280
Affinity Capture-MS
Homo sapiens
27
C11orf52
91894
Proximity Label-MS
Homo sapiens
28
RPN2
6185
Proximity Label-MS
Homo sapiens
29
CCDC47
57003
Affinity Capture-MS
Homo sapiens
30
F2RL1
Affinity Capture-MS
Homo sapiens
31
LMAN2
10960
Affinity Capture-MS
Homo sapiens
32
RAB35
11021
Proximity Label-MS
Homo sapiens
33
Kif2c
73804
Affinity Capture-MS
Mus musculus
34
KRTCAP2
200185
Affinity Capture-MS
Homo sapiens
35
PTH1R
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
36
GPR17
2840
Affinity Capture-MS
Homo sapiens
37
LAMTOR1
55004
Proximity Label-MS
Homo sapiens
38
KCNK1
Affinity Capture-MS
Homo sapiens
39
C1orf64
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
40
OR5H1
Affinity Capture-MS
Homo sapiens
41
GJA1
2697
Proximity Label-MS
Homo sapiens
42
P2RY8
Affinity Capture-MS
Homo sapiens
43
OR4N2
Affinity Capture-MS
Homo sapiens
44
DNAJC5
80331
Proximity Label-MS
Homo sapiens
45
SPDEF
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
46
KCNA6
Affinity Capture-MS
Homo sapiens
47
GPR182
Affinity Capture-MS
Homo sapiens
48
SLC4A8
9498
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
49
MOV10
4343
Affinity Capture-RNA
Homo sapiens
50
RPN1
6184
Proximity Label-MS
Homo sapiens
51
TMEM63A
9725
Affinity Capture-MS
Homo sapiens
52
ELOVL5
60481
Proximity Label-MS
Homo sapiens
53
DHCR24
1718
Affinity Capture-MS
Homo sapiens
54
NMUR2
Affinity Capture-MS
Homo sapiens
55
ELL2
22936
Affinity Capture-MS
Homo sapiens
56
ATXN1
6310
Two-hybrid
Homo sapiens
57
P2RY2
5029
Affinity Capture-MS
Homo sapiens
58
VIPR2
Affinity Capture-MS
Homo sapiens
59
C4orf32
Affinity Capture-MS
Homo sapiens
60
APLNR
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
61
TTYH1
Affinity Capture-MS
Homo sapiens
62
CANX
821
Affinity Capture-MS
Homo sapiens
63
RAB7A
7879
Proximity Label-MS
Homo sapiens
64
ATL3
25923
Affinity Capture-MS
Homo sapiens
65
PANX1
24145
Proximity Label-MS
Homo sapiens
66
SLC41A3
54946
Affinity Capture-MS
Homo sapiens
67
LAMP1
3916
Proximity Label-MS
Homo sapiens
68
CRELD1
78987
Affinity Capture-MS
Homo sapiens
69
BCAP31
10134
Proximity Label-MS
Homo sapiens
70
HSD3B7
80270
Proximity Label-MS
Homo sapiens
71
LGALS9B
284194
Affinity Capture-MS
Homo sapiens
72
ARF6
382
Proximity Label-MS
Homo sapiens
73
TBXA2R
6915
Affinity Capture-MS
Homo sapiens
74
Vps4b
20479
Affinity Capture-MS
Mus musculus
75
FAM134C
162427
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
76
ATP2A1
487
Proximity Label-MS
Homo sapiens
77
CMTM5
Affinity Capture-MS
Homo sapiens
78
ACKR2
Affinity Capture-MS
Homo sapiens
79
GPR21
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
80
VIPR1
Affinity Capture-MS
Homo sapiens
81
CLGN
1047
Affinity Capture-MS
Homo sapiens
82
NXF1
10482
Affinity Capture-RNA
Homo sapiens
83
GABRE
Affinity Capture-MS
Homo sapiens
84
SIDT2
51092
Affinity Capture-MS
Homo sapiens
85
OPALIN
Affinity Capture-MS
Homo sapiens
86
XPR1
9213
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
87
LGALS3
3958
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
88
SLC39A8
64116
Affinity Capture-MS
Homo sapiens
89
TSPAN15
23555
Affinity Capture-MS
Homo sapiens
90
B4GAT1
11041
Affinity Capture-MS
Homo sapiens
91
DDX58
23586
Affinity Capture-RNA
Homo sapiens
92
REP15
Affinity Capture-MS
Homo sapiens
93
Myh10
77579
Affinity Capture-MS
Mus musculus
94
ESR1
Affinity Capture-MS
Homo sapiens
95
GPR52
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
96
RAB2A
5862
Proximity Label-MS
Homo sapiens
97
SEC61B
10952
Proximity Label-MS
Homo sapiens
98
LGALS8
3964
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
99
OR52I1
Affinity Capture-MS
Homo sapiens
100
ATP2B2
491
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
101
LPAR2
9170
Affinity Capture-MS
Homo sapiens
102
TMC4
Affinity Capture-MS
Homo sapiens
103
DNAJC1
64215
Proximity Label-MS
Homo sapiens
104
KRAS
3845
Proximity Label-MS
Homo sapiens
105
RAB5C
5878
Proximity Label-MS
Homo sapiens
106
ADGRE5
976
Affinity Capture-MS
Homo sapiens
107
NKAIN1
Affinity Capture-MS
Homo sapiens
108
CCR6
Affinity Capture-MS
Homo sapiens
109
CAV1
857
Proximity Label-MS
Homo sapiens
110
S1PR4
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which SLC4A2 is involved