Gene description for SLC39A8
Gene name solute carrier family 39 (zinc transporter), member 8
Gene symbol SLC39A8
Other names/aliases BIGM103
LZT-Hs6
PP3105
ZIP8
Species Homo sapiens
 Database cross references - SLC39A8
ExoCarta ExoCarta_64116
Vesiclepedia VP_64116
Entrez Gene 64116
HGNC 20862
MIM 608732
UniProt Q9C0K1  
 SLC39A8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC39A8
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 TAS
    monoatomic cation:bicarbonate symporter activity GO:0140410 IBA
    monoatomic cation:bicarbonate symporter activity GO:0140410 IDA
    zinc:bicarbonate symporter activity GO:0140412 IEA
Biological Process
    DNA-templated transcription GO:0006351 IEA
    regulation of DNA-templated transcription GO:0006355 IMP
    protein N-linked glycosylation GO:0006487 ISS
    arginine metabolic process GO:0006525 ISS
    cobalt ion transport GO:0006824 ISS
    zinc ion transport GO:0006829 IMP
    intracellular zinc ion homeostasis GO:0006882 IDA
    mercury ion transport GO:0015694 IEA
    bicarbonate transport GO:0015701 ISS
    intracellular monoatomic cation homeostasis GO:0030003 IBA
    intracellular manganese ion homeostasis GO:0030026 ISS
    extracellular matrix organization GO:0030198 IMP
    regulation of membrane potential GO:0042391 IMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    negative regulation of inflammatory response GO:0050728 IMP
    leukocyte adhesion to arterial endothelial cell GO:0061757 ISS
    cadmium ion transmembrane transport GO:0070574 IDA
    manganese ion transmembrane transport GO:0071421 IMP
    zinc ion transmembrane transport GO:0071577 IDA
    zinc ion transmembrane transport GO:0071577 IMP
    zinc ion transmembrane transport GO:0071577 TAS
    zinc ion import across plasma membrane GO:0071578 IBA
    zinc ion import across plasma membrane GO:0071578 IMP
    plasma membrane selenite transport GO:0097080 IDA
    iron ion import across plasma membrane GO:0098711 IDA
    cellular detoxification of cadmium ion GO:0098849 IMP
    cartilage homeostasis GO:1990079 ISS
    mitochondrial manganese ion transmembrane transport GO:1990540 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    organelle membrane GO:0031090 IDA
 Experiment description of studies that identified SLC39A8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC39A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 SPPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C1GALT1C1 29071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FASN 2194
Negative Genetic Homo sapiens
5 C1orf43 25912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CANX 821
Affinity Capture-MS Homo sapiens
8 LEMD2 221496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 HMOX1 3162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 EXTL2 2135
Affinity Capture-MS Homo sapiens
11 GOLIM4 27333
Affinity Capture-MS Homo sapiens
12 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ERGIC3 51614
Affinity Capture-MS Homo sapiens
14 TSPAN15 23555
Affinity Capture-MS Homo sapiens
15 GPD2 2820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 STX4 6810
Affinity Capture-MS Homo sapiens
17 C3orf33  
Affinity Capture-MS Homo sapiens
18 SGPP1 81537
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TMEM179B 374395
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MGAT5 4249
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VANGL2  
Affinity Capture-MS Homo sapiens
22 ERGIC2 51290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 EDA  
Affinity Capture-MS Homo sapiens
24 TAOK2 9344
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ST7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TMPPE  
Affinity Capture-MS Homo sapiens
27 STX7 8417
Affinity Capture-MS Homo sapiens
28 RMDN2 151393
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GP1BB 2812
Affinity Capture-MS Homo sapiens
30 CHSY1 22856
Affinity Capture-MS Homo sapiens
31 PTGER4  
Two-hybrid Homo sapiens
32 SLC9A6 10479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SLC22A18 5002
Affinity Capture-MS Homo sapiens
34 TMX2 51075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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