Gene description for HMOX1
Gene name	heme oxygenase 1
Gene symbol	HMOX1
Other names/aliases	HMOX1D HO-1 HSP32 bK286B10
Species	Homo sapiens
Database cross references - HMOX1
ExoCarta	ExoCarta_3162
Entrez Gene	3162
HGNC	5013
MIM	141250
UniProt	P09601
HMOX1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for HMOX1

Molecular Function     signal transducer activity GO:0004871 IMP     phospholipase D activity GO:0004630 IEA     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     heme oxygenase (decyclizing) activity GO:0004392 IMP     heme binding GO:0020037 IDA     enzyme binding GO:0019899 ISS     protein homodimerization activity GO:0042803 IDA Biological Process     cell death GO:0008219 ISS     negative regulation of leukocyte migration GO:0002686 TAS     intracellular signal transduction GO:0035556 TAS     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA     negative regulation of DNA binding GO:0043392 IEA     negative regulation of mast cell cytokine production GO:0032764 IEA     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IEA     small GTPase mediated signal transduction GO:0007264 IEA     response to hydrogen peroxide GO:0042542 ISS     iron ion homeostasis GO:0055072 IMP     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 ISS     cellular iron ion homeostasis GO:0006879 TAS     small molecule metabolic process GO:0044281 TAS     cellular response to arsenic-containing substance GO:0071243 IEA     regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395 IEA     porphyrin-containing compound metabolic process GO:0006778 TAS     excretion GO:0007588 IC     low-density lipoprotein particle clearance GO:0034383 TAS     heme oxidation GO:0006788 IDA     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP     cellular response to cadmium ion GO:0071276 IEA     regulation of angiogenesis GO:0045765 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     response to nicotine GO:0035094 IDA     positive regulation of smooth muscle cell proliferation GO:0048661 IDA     response to estrogen GO:0043627 IEA     negative regulation of muscle cell apoptotic process GO:0010656 IEA     endothelial cell proliferation GO:0001935 TAS     regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 ISS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IMP     smooth muscle hyperplasia GO:0014806 TAS     negative regulation of mast cell degranulation GO:0043305 IEA     regulation of blood pressure GO:0008217 IEA     protein homooligomerization GO:0051260 IDA     cellular response to heat GO:0034605 IMP     transmembrane transport GO:0055085 TAS     positive regulation of vasodilation GO:0045909 IC     wound healing involved in inflammatory response GO:0002246 IMP     cellular response to nutrient GO:0031670 IEA     cellular response to hypoxia GO:0071456 IEP     positive regulation of angiogenesis GO:0045766 IEA     heme catabolic process GO:0042167 TAS     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     angiogenesis GO:0001525 TAS     erythrocyte homeostasis GO:0034101 IMP     response to oxidative stress GO:0006979 IMP     positive regulation of chemokine biosynthetic process GO:0045080 TAS Subcellular Localization     nucleolus GO:0005730 IEA     perinuclear region of cytoplasm GO:0048471 IDA     membrane GO:0016020 TAS     extracellular space GO:0005615 TAS     endoplasmic reticulum membrane GO:0005789 TAS     caveola GO:0005901 IEA     cytosol GO:0005829 IEA     nucleus GO:0005634 ISS     endoplasmic reticulum GO:0005783 ISS