Gene description for SMO
Gene name	smoothened, frizzled class receptor
Gene symbol	SMO
Other names/aliases	FZD11 Gx SMOH
Species	Homo sapiens
Database cross references - SMO
ExoCarta	ExoCarta_6608
Entrez Gene	6608
HGNC	11119
MIM	601500
UniProt	Q99835
SMO identified in exosomes derived from the following tissue/cell type
Urine	19056867
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for SMO

Molecular Function     G-protein coupled receptor activity GO:0004930 IBA     drug binding GO:0008144 IDA     Wnt-activated receptor activity GO:0042813 IBA     Wnt-protein binding GO:0017147 IBA     patched binding GO:0005113 IPI     protein binding GO:0005515 IPI Biological Process     multicellular organism growth GO:0035264 IEA     osteoblast differentiation GO:0001649 IEA     odontogenesis of dentin-containing tooth GO:0042475 IEA     dorsal/ventral neural tube patterning GO:0021904 IEA     regulation of heart morphogenesis GO:2000826 ISS     midgut development GO:0007494 ISS     renal system development GO:0072001 IEP     negative regulation of epithelial cell differentiation GO:0030857 IEA     positive regulation of neuroblast proliferation GO:0002052 IEA     skeletal muscle fiber development GO:0048741 IEA     mammary gland epithelial cell differentiation GO:0060644 IEA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of DNA binding GO:0043392 ISS     G-protein coupled receptor signaling pathway GO:0007186 IEA     thalamus development GO:0021794 IEA     cerebellar cortex morphogenesis GO:0021696 IEA     smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 IEA     positive regulation of protein import into nucleus GO:0042307 IEA     positive regulation of smoothened signaling pathway GO:0045880 IEA     anterior/posterior pattern specification GO:0009952 IEA     myoblast migration GO:0051451 IEA     determination of left/right asymmetry in lateral mesoderm GO:0003140 ISS     hair follicle morphogenesis GO:0031069 IEA     positive regulation of epithelial cell proliferation GO:0050679 IEA     in utero embryonic development GO:0001701 IEA     non-canonical Wnt signaling pathway GO:0035567 IBA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     epithelial-mesenchymal cell signaling GO:0060684 IEA     somite development GO:0061053 ISS     heart looping GO:0001947 ISS     smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 IEA     detection of cell density by contact stimulus involved in contact inhibition GO:0060248 IMP     type B pancreatic cell development GO:0003323 IEA     protein stabilization GO:0050821 IEA     canonical Wnt signaling pathway GO:0060070 IBA     mesenchymal to epithelial transition involved in metanephric renal vesicle formation GO:0072285 ISS     negative regulation of gene expression GO:0010629 ISS     ventral midline determination GO:0007371 ISS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     vasculogenesis GO:0001570 IEA     negative regulation of hair follicle development GO:0051799 IEA     atrial septum morphogenesis GO:0060413 IEA     positive regulation of gene expression GO:0010628 ISS     forebrain morphogenesis GO:0048853 ISS     pancreas morphogenesis GO:0061113 IEA     regulation of stem cell maintenance GO:2000036 IEA     central nervous system neuron differentiation GO:0021953 IEA     smoothened signaling pathway GO:0007224 IMP     protein localization to nucleus GO:0034504 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     neural crest cell migration GO:0001755 IEA     cell fate specification GO:0001708 IEA     cellular response to cholesterol GO:0071397 ISS     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISS     positive regulation of hh target transcription factor activity GO:0007228 ISS Subcellular Localization     plasma membrane GO:0005886 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     integral component of membrane GO:0016021 IBA     extracellular exosome GO:0070062 IDA     primary cilium GO:0072372 TAS     ciliary tip GO:0097542 TAS     endocytic vesicle membrane GO:0030666 TAS     Golgi apparatus GO:0005794 IDA     ciliary membrane GO:0060170 TAS     caveola GO:0005901 IDA