Gene description for SLC41A3
Gene name solute carrier family 41, member 3
Gene symbol SLC41A3
Other names/aliases SLC41A1-L2
Species Homo sapiens
 Database cross references - SLC41A3
ExoCarta ExoCarta_54946
Vesiclepedia VP_54946
Entrez Gene 54946
HGNC 31046
MIM 610803
UniProt Q96GZ6  
 SLC41A3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC41A3
Molecular Function
    protein binding GO:0005515 IPI
    magnesium:sodium antiporter activity GO:0061768 IDA
Biological Process
    sodium ion transmembrane transport GO:0035725 IEA
    mitochondrial magnesium ion transmembrane transport GO:0045016 IDA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified SLC41A3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC41A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 SUFU 51684
Two-hybrid Homo sapiens
3 SLC17A2  
Affinity Capture-MS Homo sapiens
4 TMBIM6 7009
Two-hybrid Homo sapiens
5 PLP1 5354
Two-hybrid Homo sapiens
6 ZDHHC12  
Affinity Capture-MS Homo sapiens
7 REL 5966
Two-hybrid Homo sapiens
8 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 IGFBP5 3488
Two-hybrid Homo sapiens
10 NPSR1  
Two-hybrid Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 MAPK6  
Two-hybrid Homo sapiens
13 CCL3L3  
Two-hybrid Homo sapiens
14 OR13J1  
Affinity Capture-MS Homo sapiens
15 SMO 6608
Two-hybrid Homo sapiens
16 CCR2  
Two-hybrid Homo sapiens
17 SMCO4  
Two-hybrid Homo sapiens
18 C4orf3  
Two-hybrid Homo sapiens
19 CREB3  
Two-hybrid Homo sapiens
20 RPN1 6184
Proximity Label-MS Homo sapiens
21 SLC12A6 9990
Affinity Capture-MS Homo sapiens
22 TMEM63A 9725
Affinity Capture-MS Homo sapiens
23 GPR37  
Two-hybrid Homo sapiens
24 ATP2B4 493
Affinity Capture-MS Homo sapiens
25 OR1D4  
Affinity Capture-MS Homo sapiens
26 TSPO2  
Two-hybrid Homo sapiens
27 PDZD3  
Two-hybrid Homo sapiens
28 NMUR2  
Affinity Capture-MS Homo sapiens
29 SLC12A9 56996
Affinity Capture-MS Homo sapiens
30 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC41A3 is involved
No pathways found





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