Gene description for ATM
Gene name ATM serine/threonine kinase
Gene symbol ATM
Other names/aliases AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
Species Homo sapiens
 Database cross references - ATM
ExoCarta ExoCarta_472
Vesiclepedia VP_472
Entrez Gene 472
HGNC 795
MIM 607585
UniProt Q13315  
 ATM identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ATM
Molecular Function
    protein dimerization activity GO:0046983 IDA
    DNA binding GO:0003677 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein binding GO:0005515 IPI
    1-phosphatidylinositol-3-kinase activity GO:0016303 IMP
    DNA-dependent protein kinase activity GO:0004677 IDA
    protein N-terminus binding GO:0047485 IDA
    ATP binding GO:0005524 IEA
    protein complex binding GO:0032403 IDA
    histone serine kinase activity GO:0035174 IEA
Biological Process
    V(D)J recombination GO:0033151 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IMP
    double-strand break repair GO:0006302 TAS
    histone mRNA catabolic process GO:0071044 IDA
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS
    replicative senescence GO:0090399 IMP
    positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 IMP
    double-strand break repair via homologous recombination GO:0000724 TAS
    cellular response to gamma radiation GO:0071480 IDA
    signal transduction GO:0007165 TAS
    mitotic spindle assembly checkpoint GO:0007094 IMP
    signal transduction involved in mitotic G2 DNA damage checkpoint GO:0072434 IMP
    pre-B cell allelic exclusion GO:0002331 ISS
    protein phosphorylation GO:0006468 IDA
    cellular response to heat GO:0034605 TAS
    negative regulation of B cell proliferation GO:0030889 IMP
    DNA repair GO:0006281 TAS
    oocyte development GO:0048599 IEA
    DNA damage induced protein phosphorylation GO:0006975 IDA
    neuron apoptotic process GO:0051402 IEA
    positive regulation of neuron apoptotic process GO:0043525 IEA
    histone-serine phosphorylation GO:0035404 IEA
    brain development GO:0007420 IEA
    heart development GO:0007507 IEA
    reciprocal meiotic recombination GO:0007131 TAS
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    response to ionizing radiation GO:0010212 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    telomere maintenance GO:0000723 IEA
    cellular response to DNA damage stimulus GO:0006974 IMP
    regulation of cellular response to heat GO:1900034 TAS
    cell cycle arrest GO:0007050 IMP
    response to hypoxia GO:0001666 IEA
    lipoprotein catabolic process GO:0042159 IEA
    protein autophosphorylation GO:0046777 IDA
    somitogenesis GO:0001756 IEA
Subcellular Localization
    spindle GO:0005819 IEA
    chromosome, telomeric region GO:0000781 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ATM in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ATM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Protein-peptide Homo sapiens
2 LIG4 3981
Protein-peptide Homo sapiens
3 Ap1b1 11764
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
4 TP53BP1 7158
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
5 RAD50 10111
Co-purification Homo sapiens
6 MSH6 2956
Co-purification Homo sapiens
7 FANCD2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 E4F1  
Protein-peptide Homo sapiens
9 MDC1  
Affinity Capture-Western Homo sapiens
10 RAD17  
Invivo Homo sapiens
Protein-peptide Homo sapiens
11 MSH2 4436
Co-purification Homo sapiens
12 Polq  
Phenotypic Enhancement Mus musculus
13 BRCA2 675
Reconstituted Complex Homo sapiens
14 H2afx 15270
Reconstituted Complex Mus musculus
15 BRCA1 672
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
16 WRN 7486
Protein-peptide Homo sapiens
17 ABL1 25
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 TP53 7157
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
19 MRE11A 4361
Co-purification Homo sapiens
Protein-peptide Homo sapiens
20 MLH1 4292
Co-purification Homo sapiens
21 CREB1  
Affinity Capture-Western Homo sapiens
22 PRKDC 5591
Protein-peptide Homo sapiens
Invitro Homo sapiens
23 BLM 641
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
24 NBN 4683
Co-purification Homo sapiens
Protein-peptide Homo sapiens
25 RFC1 5981
Co-purification Homo sapiens
26 TERF1 7013
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 RHEB 6009
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
28 Chek1  
Reconstituted Complex Mus musculus
29 ATM 472
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
30 MCM2 4171
Biochemical Activity Homo sapiens
31 AP2A2 161
Protein-peptide Homo sapiens
32 CHEK1  
Protein-peptide Homo sapiens
33 AP1B1 162
Protein-peptide Homo sapiens
34 PEX5 5830
Two-hybrid Homo sapiens
35 SMC1A 8243
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 PTS  
Protein-peptide Homo sapiens
37 EIF4EBP1  
Protein-peptide Homo sapiens
38 Terc  
Phenotypic Enhancement Mus musculus
39 RAD51  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 Ap3b2  
Affinity Capture-Western Mus musculus
41 RBBP8  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
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