Gene description for C1orf27
Gene name chromosome 1 open reading frame 27
Gene symbol C1orf27
Other names/aliases ODR4
TTG1
odr-4
Species Homo sapiens
 Database cross references - C1orf27
ExoCarta ExoCarta_54953
Vesiclepedia VP_54953
Entrez Gene 54953
HGNC 24299
MIM 609335
UniProt Q5SWX8  
 C1orf27 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for C1orf27
Biological Process
    protein localization GO:0008104 IBA
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified C1orf27 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for C1orf27
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KDF1  
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 UFSP2 55325
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
4 REEP5 7905
Affinity Capture-MS Homo sapiens
5 GPM6A 2823
Affinity Capture-MS Homo sapiens
6 CYP26B1  
Affinity Capture-MS Homo sapiens
7 SNX27 81609
Affinity Capture-MS Homo sapiens
8 FASN 2194
Negative Genetic Homo sapiens
9 FAM84B 157638
Affinity Capture-MS Homo sapiens
10 NAPG 8774
Affinity Capture-MS Homo sapiens
11 FAM177A1 283635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 UBXN4 23190
Affinity Capture-MS Homo sapiens
13 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
14 TP53 7157
Affinity Capture-MS Homo sapiens
15 FAS 355
Affinity Capture-MS Homo sapiens
16 NAPA 8775
Affinity Capture-MS Homo sapiens
17 DUOXA2  
Affinity Capture-MS Homo sapiens
18 CCDC107  
Affinity Capture-MS Homo sapiens
19 NF2 4771
Negative Genetic Homo sapiens
20 USP36  
Affinity Capture-MS Homo sapiens
21 ASIC4  
Affinity Capture-MS Homo sapiens
22 TMEM9B 56674
Affinity Capture-MS Homo sapiens
23 BTN3A2 11118
Affinity Capture-MS Homo sapiens
24 CD27  
Affinity Capture-MS Homo sapiens
25 TCL1A  
Affinity Capture-MS Homo sapiens
26 TYROBP  
Affinity Capture-MS Homo sapiens
27 C9orf9  
Affinity Capture-MS Homo sapiens
28 ATM 472
Affinity Capture-MS Homo sapiens
29 HM13 81502
Affinity Capture-MS Homo sapiens
30 TMX1 81542
Affinity Capture-MS Homo sapiens
31 LRRC25  
Affinity Capture-MS Homo sapiens
32 CD79A  
Affinity Capture-MS Homo sapiens
33 BTN3A3 10384
Affinity Capture-MS Homo sapiens
34 NUP35 129401
Proximity Label-MS Homo sapiens
35 SLAMF1 6504
Affinity Capture-MS Homo sapiens
36 CYP3A7  
Affinity Capture-MS Homo sapiens
37 NPL 80896
Affinity Capture-MS Homo sapiens
38 FAXC  
Affinity Capture-MS Homo sapiens
39 CD244 51744
Affinity Capture-MS Homo sapiens
40 ILVBL 10994
Affinity Capture-MS Homo sapiens
41 PSMD14 10213
Affinity Capture-MS Homo sapiens
42 AMIGO1  
Affinity Capture-MS Homo sapiens
43 UFL1 23376
Affinity Capture-MS Homo sapiens
44 KIAA1429 25962
Affinity Capture-MS Homo sapiens
45 CACNG4  
Affinity Capture-MS Homo sapiens
46 TIGIT  
Affinity Capture-MS Homo sapiens
47 CEACAM21  
Affinity Capture-MS Homo sapiens
48 CHMP6 79643
Affinity Capture-MS Homo sapiens
49 FAM134C 162427
Affinity Capture-MS Homo sapiens
50 DLK1  
Affinity Capture-MS Homo sapiens
51 SEC62 7095
Affinity Capture-MS Homo sapiens
52 LRIG1 26018
Affinity Capture-MS Homo sapiens
53 PCDHB3  
Affinity Capture-MS Homo sapiens
54 PTPRCAP 5790
Affinity Capture-MS Homo sapiens
55 HLA-B 3106
Affinity Capture-MS Homo sapiens
56 ASIC1  
Affinity Capture-MS Homo sapiens
57 REEP6  
Affinity Capture-MS Homo sapiens
58 RPA3 6119
Proximity Label-MS Homo sapiens
59 IL27RA 9466
Affinity Capture-MS Homo sapiens
60 PCDHA4 56144
Affinity Capture-MS Homo sapiens
61 PCDHA12  
Affinity Capture-MS Homo sapiens
62 HUWE1 10075
Affinity Capture-MS Homo sapiens
63 CDHR5 53841
Affinity Capture-MS Homo sapiens
64 CUL7 9820
Affinity Capture-MS Homo sapiens
65 DDRGK1 65992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 GRB2 2885
Affinity Capture-MS Homo sapiens
67 GPRC5B 51704
Affinity Capture-MS Homo sapiens
68 ADAM18  
Affinity Capture-MS Homo sapiens
69 LPPR2  
Affinity Capture-MS Homo sapiens
70 SAYSD1  
Affinity Capture-MS Homo sapiens
71 PRMT1 3276
Affinity Capture-MS Homo sapiens
72 C17orf62 79415
Affinity Capture-MS Homo sapiens
73 SEC61B 10952
Affinity Capture-MS Homo sapiens
74 CYLD  
Affinity Capture-MS Homo sapiens
75 LRRC3B  
Affinity Capture-MS Homo sapiens
76 FMR1NB  
Affinity Capture-MS Homo sapiens
77 COMT 1312
Affinity Capture-MS Homo sapiens
78 HLA-C 3107
Affinity Capture-MS Homo sapiens
79 CCDC47 57003
Affinity Capture-MS Homo sapiens
80 SLC51B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C1orf27 is involved
No pathways found





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