Gene description for NF2
Gene name	neurofibromin 2 (merlin)
Gene symbol	NF2
Other names/aliases	ACN BANF SCH
Species	Homo sapiens
Database cross references - NF2
ExoCarta	ExoCarta_4771
Entrez Gene	4771
HGNC	7773
MIM	607379
UniProt	P35240
NF2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Melanoma cells	25950383

Gene ontology annotations for NF2

Molecular Function     actin binding GO:0003779 IEA     protein binding GO:0005515 IPI Biological Process     negative regulation of MAPK cascade GO:0043409 IEA     negative regulation of JAK-STAT cascade GO:0046426 IDA     ectoderm development GO:0007398 IEA     negative regulation of protein kinase activity GO:0006469 IEA     regulation of hippo signaling GO:0035330 IMP     positive regulation of cell differentiation GO:0045597 IEA     cell-cell junction organization GO:0045216 IEA     lens fiber cell differentiation GO:0070306 IEA     regulation of protein localization to nucleus GO:1900180 IEA     regulation of protein stability GO:0031647 IEA     regulation of neural precursor cell proliferation GO:2000177 IEA     small GTPase mediated signal transduction GO:0007264 TAS     negative regulation of cell-cell adhesion GO:0022408 IDA     negative regulation of cell-matrix adhesion GO:0001953 TAS     odontogenesis of dentin-containing tooth GO:0042475 IEA     Schwann cell proliferation GO:0014010 IMP     mesoderm formation GO:0001707 IEA     negative regulation of cell migration GO:0030336 TAS     negative regulation of cell proliferation GO:0008285 IMP     actin cytoskeleton organization GO:0030036 IMP     negative regulation of tyrosine phosphorylation of Stat5 protein GO:0042524 IDA     negative regulation of tyrosine phosphorylation of Stat3 protein GO:0042518 IDA     positive regulation of stress fiber assembly GO:0051496 IMP     hippocampus development GO:0021766 IEA     negative regulation of DNA replication GO:0008156 IMP Subcellular Localization     cortical actin cytoskeleton GO:0030864 IEA     lamellipodium GO:0030027 IEA     adherens junction GO:0005912 IEA     extrinsic component of membrane GO:0019898 IEA     early endosome GO:0005769 IDA     nucleus GO:0005634 IDA     cleavage furrow GO:0032154 IEA     ruffle membrane GO:0032587 IEA     apical part of cell GO:0045177 IEA     membrane GO:0016020 IDA     cytoskeleton GO:0005856 TAS     cytoplasm GO:0005737 IDA     nucleolus GO:0005730 IDA     plasma membrane GO:0005886 TAS     filopodium membrane GO:0031527 IEA     perinuclear region of cytoplasm GO:0048471 IDA