Gene description for TBL2
Gene name transducin (beta)-like 2
Gene symbol TBL2
Other names/aliases WBSCR13
WS-betaTRP
Species Homo sapiens
 Database cross references - TBL2
ExoCarta ExoCarta_26608
Vesiclepedia VP_26608
Entrez Gene 26608
HGNC 11586
MIM 605842
UniProt Q9Y4P3  
 TBL2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TBL2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    translation initiation factor binding GO:0031369 IPI
    phosphoprotein binding GO:0051219 IDA
Biological Process
    endoplasmic reticulum unfolded protein response GO:0030968 IBA
    endoplasmic reticulum unfolded protein response GO:0030968 IMP
    cellular response to glucose starvation GO:0042149 IMP
    cellular response to hypoxia GO:0071456 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 NAS
 Experiment description of studies that identified TBL2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACOT7 11332
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 ISG15 9636
Affinity Capture-MS Homo sapiens
4 LGR4 55366
Affinity Capture-MS Homo sapiens
5 TSPAN15 23555
Affinity Capture-MS Homo sapiens
6 NDUFS1 4719
Co-fractionation Homo sapiens
7 CDH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RPS19 6223
Co-fractionation Homo sapiens
9 GLRA3  
Affinity Capture-MS Homo sapiens
10 C9orf78 51759
Affinity Capture-MS Homo sapiens
11 TMEM9B 56674
Affinity Capture-MS Homo sapiens
12 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 FAXC  
Affinity Capture-MS Homo sapiens
14 RTN4 57142
Affinity Capture-MS Homo sapiens
15 SOX2  
Affinity Capture-MS Homo sapiens
16 GSK3A 2931
Affinity Capture-MS Homo sapiens
17 PARK2  
Affinity Capture-MS Homo sapiens
18 TEX264 51368
Affinity Capture-MS Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
20 NDUFA7 4701
Co-fractionation Homo sapiens
21 COPS5 10987
Affinity Capture-MS Homo sapiens
22 SSR1 6745
Proximity Label-MS Homo sapiens
23 PIGH  
Affinity Capture-MS Homo sapiens
24 C3orf52  
Affinity Capture-MS Homo sapiens
25 SERPINH1 871
Co-fractionation Homo sapiens
26 DNAJC16  
Affinity Capture-MS Homo sapiens
27 SARNP 84324
Co-fractionation Homo sapiens
28 CCDC47 57003
Affinity Capture-MS Homo sapiens
29 ATG16L1 55054
Affinity Capture-MS Homo sapiens
30 GPRC5C 55890
Affinity Capture-MS Homo sapiens
31 FAM20C 56975
Affinity Capture-MS Homo sapiens
32 KIF14 9928
Affinity Capture-MS Homo sapiens
33 NF2 4771
Affinity Capture-MS Homo sapiens
34 EIF2AK3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 NDUFS4 4724
Co-fractionation Homo sapiens
36 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 SKAP1 8631
Affinity Capture-MS Homo sapiens
39 ITGAD  
Affinity Capture-MS Homo sapiens
40 CHCHD3 54927
Co-fractionation Homo sapiens
41 SCAP  
Affinity Capture-MS Homo sapiens
42 VSIG4  
Affinity Capture-MS Homo sapiens
43 PRKRA 8575
Affinity Capture-MS Homo sapiens
44 PMAIP1  
Affinity Capture-MS Homo sapiens
45 PCDHGC4  
Affinity Capture-MS Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 NDUFA2 4695
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
48 BCL6  
Affinity Capture-MS Homo sapiens
49 HECTD1 25831
Affinity Capture-MS Homo sapiens
50 RPLP0 6175
Affinity Capture-MS Homo sapiens
51 MAGEB2 4113
Affinity Capture-MS Homo sapiens
52 SEC61B 10952
Proximity Label-MS Homo sapiens
53 RMDN3 55177
Proximity Label-MS Homo sapiens
54 RRP8  
Affinity Capture-MS Homo sapiens
55 SEC63 11231
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Rab5c 19345
Affinity Capture-MS Mus musculus
57 ZBTB2 57621
Affinity Capture-MS Homo sapiens
58 SUGP1  
Co-fractionation Homo sapiens
59 RPN2 6185
Proximity Label-MS Homo sapiens
60 RPL10 6134
Affinity Capture-MS Homo sapiens
61 CIAO1 9391
Affinity Capture-MS Homo sapiens
62 LRRC59 55379
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
63 PANX1 24145
Proximity Label-MS Homo sapiens
64 CHRNA1  
Affinity Capture-MS Homo sapiens
65 CUL3 8452
Affinity Capture-MS Homo sapiens
66 NR3C1 2908
Proximity Label-MS Homo sapiens
67 BTF3 689
Affinity Capture-MS Homo sapiens
68 CLEC4A  
Affinity Capture-MS Homo sapiens
69 RBM27  
Co-fractionation Homo sapiens
70 PDPK1 5170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RIPK4  
Affinity Capture-MS Homo sapiens
72 SUZ12  
Affinity Capture-MS Homo sapiens
73 TMEM169  
Affinity Capture-MS Homo sapiens
74 CNR2  
Affinity Capture-MS Homo sapiens
75 RPA3 6119
Proximity Label-MS Homo sapiens
76 ATP2A1 487
Proximity Label-MS Homo sapiens
77 EMC2 9694
Affinity Capture-MS Homo sapiens
78 NCLN 56926
Affinity Capture-MS Homo sapiens
79 DDRGK1 65992
Affinity Capture-MS Homo sapiens
80 RNF2  
Affinity Capture-MS Homo sapiens
81 Rpl35 66489
Affinity Capture-MS Mus musculus
82 LMNA 4000
Proximity Label-MS Homo sapiens
83 PTAFR  
Affinity Capture-MS Homo sapiens
84 IMMT 10989
Co-fractionation Homo sapiens
85 RPL13 6137
Affinity Capture-MS Homo sapiens
86 GRK5 2869
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 SOD2 6648
Co-fractionation Homo sapiens
89 HLA-G 3135
Affinity Capture-MS Homo sapiens
90 GABRE  
Affinity Capture-MS Homo sapiens
91 FBXL6  
Affinity Capture-MS Homo sapiens
92 RTN3 10313
Affinity Capture-MS Homo sapiens
93 MFSD4  
Affinity Capture-MS Homo sapiens
94 SF3B4 10262
Co-fractionation Homo sapiens
95 SCP2 6342
Co-fractionation Homo sapiens
96 KCNC4  
Affinity Capture-MS Homo sapiens
97 TSPAN17 26262
Affinity Capture-MS Homo sapiens
98 USP44  
Affinity Capture-MS Homo sapiens
99 NUP35 129401
Proximity Label-MS Homo sapiens
100 DDX58 23586
Affinity Capture-RNA Homo sapiens
101 WIF1 11197
Affinity Capture-MS Homo sapiens
102 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 UFL1 23376
Affinity Capture-MS Homo sapiens
104 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 PTPN5  
Affinity Capture-MS Homo sapiens
106 CDV3 55573
Co-fractionation Homo sapiens
107 SEC62 7095
Proximity Label-MS Homo sapiens
108 FAM189A2  
Affinity Capture-MS Homo sapiens
109 EVA1B 55194
Affinity Capture-MS Homo sapiens
110 DNAJC1 64215
Affinity Capture-MS Homo sapiens
111 C9orf72  
Affinity Capture-MS Homo sapiens
112 WFS1 7466
Co-fractionation Homo sapiens
113 MRPL53  
Co-fractionation Homo sapiens
114 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 EP300 2033
Affinity Capture-MS Homo sapiens
116 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TBL2 is involved
No pathways found





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