Gene description for SKAP1
Gene name src kinase associated phosphoprotein 1
Gene symbol SKAP1
Other names/aliases HEL-S-81p
SCAP1
SKAP55
Species Homo sapiens
 Database cross references - SKAP1
ExoCarta ExoCarta_8631
Vesiclepedia VP_8631
Entrez Gene 8631
HGNC 15605
MIM 604969
UniProt Q86WV1  
 SKAP1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SKAP1
Molecular Function
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 TAS
    protein kinase binding GO:0019901 IPI
    protein phosphatase binding GO:0019903 IPI
    SH2 domain binding GO:0042169 IDA
Biological Process
    positive regulation of cell-matrix adhesion GO:0001954 IGI
    adaptive immune response GO:0002250 IEA
    positive regulation of adaptive immune response GO:0002821 IDA
    positive regulation of integrin activation GO:0033625 IDA
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 IGI
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    T cell receptor signaling pathway GO:0050852 IMP
    protein localization to plasma membrane GO:0072659 IEA
    positive regulation of leukocyte cell-cell adhesion GO:1903039 IDA
Subcellular Localization
    immunological synapse GO:0001772 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IEA
    T cell receptor complex GO:0042101 IEA
    plasma membrane raft GO:0044853 IDA
 Experiment description of studies that identified SKAP1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SKAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM208A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MCM8 84515
Affinity Capture-MS Homo sapiens
3 PER1  
Affinity Capture-MS Homo sapiens
4 KSR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ALMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZNHIT2 741
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 JPH1 56704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SETX  
Affinity Capture-MS Homo sapiens
9 APP 351
Reconstituted Complex Homo sapiens
10 FYB 2533
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 URI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 C21orf2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SENP1  
Affinity Capture-MS Homo sapiens
14 TRMT44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SRC 6714
Reconstituted Complex Homo sapiens
16 PUSL1  
Affinity Capture-MS Homo sapiens
17 POLR1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PIK3C3 5289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 POLRMT 5442
Affinity Capture-MS Homo sapiens
20 PLD2 5338
Affinity Capture-MS Homo sapiens
21 SETD5 55209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ZNF644  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SENP5  
Affinity Capture-MS Homo sapiens
24 RECQL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PKN3 29941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 EML3 256364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PLEKHH3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PTPRC 5788
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
30 WRN 7486
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 UCKL1 54963
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 POLR1A 25885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 AP3M1 26985
Affinity Capture-MS Homo sapiens
34 CC2D1B 200014
Affinity Capture-MS Homo sapiens
35 UXT 8409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TBL2 26608
Affinity Capture-MS Homo sapiens
37 LYN 4067
Reconstituted Complex Homo sapiens
38 SKAP2 8935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 LOC81691 81691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NCAPD3 23310
Affinity Capture-MS Homo sapiens
41 FYN 2534
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 TIGD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 NEK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ZNF324  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 HPS3 84343
Affinity Capture-MS Homo sapiens
46 MTMR1 8776
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 EXPH5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CUL2 8453
Affinity Capture-MS Homo sapiens
49 RTEL1 51750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CD3EAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 UTP15 84135
Affinity Capture-MS Homo sapiens
52 TRMT1 55621
Affinity Capture-MS Homo sapiens
53 SEC63 11231
Affinity Capture-MS Homo sapiens
54 DDX11L8  
Affinity Capture-MS Homo sapiens
55 MYCBP2 23077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 POLR3A 11128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DOCK7 85440
Affinity Capture-MS Homo sapiens
58 NCAPH2  
Affinity Capture-MS Homo sapiens
59 GTF3C1  
Affinity Capture-MS Homo sapiens
60 ASPM 259266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ELP3 55140
Affinity Capture-MS Homo sapiens
62 PHLDB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CCP110  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 USP54 159195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 HOOK3 84376
Affinity Capture-MS Homo sapiens
66 TTF2 8458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SBF1 6305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 FAM102A  
Two-hybrid Homo sapiens
69 PKN2 5586
Affinity Capture-MS Homo sapiens
70 PPHLN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 MAP7D1 55700
Affinity Capture-MS Homo sapiens
72 ATAD3B 83858
Affinity Capture-MS Homo sapiens
73 NEFL 4747
Affinity Capture-MS Homo sapiens
74 MYO9B 4650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 MYO9A 4649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SUGCT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 NPHP4 261734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PAX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 SH2D4A 63898
Two-hybrid Homo sapiens
80 PRR14L 253143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
82 DYNLL2 140735
Two-hybrid Homo sapiens
83 GRB2 2885
Affinity Capture-Western Homo sapiens
84 POLR1B 84172
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 GTPBP6  
Affinity Capture-MS Homo sapiens
86 POLR2L 5441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 LCK 3932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
89 ATXN2 6311
Affinity Capture-MS Homo sapiens
90 NEK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PRAM1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 APPBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 SKAP1 8631
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 SUPT6H 6830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 BLCAP  
Two-hybrid Homo sapiens
96 POLR3B 55703
Affinity Capture-MS Homo sapiens
97 POLA1  
Affinity Capture-MS Homo sapiens
98 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 POLR1D 51082
Affinity Capture-MS Homo sapiens
100 PDRG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PIK3R3 8503
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SKAP1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here