Gene description for POLR3B
Gene name polymerase (RNA) III (DNA directed) polypeptide B
Gene symbol POLR3B
Other names/aliases C128
HLD8
INMAP
RPC2
Species Homo sapiens
 Database cross references - POLR3B
ExoCarta ExoCarta_55703
Vesiclepedia VP_55703
Entrez Gene 55703
HGNC 30348
MIM 614366
UniProt Q9NW08  
 POLR3B identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for POLR3B
Molecular Function
    RNA polymerase I activity GO:0001054 IEA
    RNA polymerase II activity GO:0001055 IEA
    RNA polymerase III activity GO:0001056 IBA
    RNA polymerase IV activity GO:0001057 IEA
    RNA polymerase V activity GO:0001058 IEA
    mitochondrial single subunit type RNA polymerase activity GO:0001065 IEA
    plastid single subunit type RNA polymerase activity GO:0001066 IEA
    DNA binding GO:0003677 IEA
    DNA-directed 5'-3' RNA polymerase activity GO:0003899 IDA
    zinc ion binding GO:0008270 IDA
    ribonucleoside binding GO:0032549 IEA
    DNA/RNA hybrid binding GO:0071667 IDA
Biological Process
    transcription by RNA polymerase IV GO:0001059 IEA
    transcription by RNA polymerase V GO:0001060 IEA
    transcription by RNA polymerase I GO:0006360 IEA
    transcription by RNA polymerase II GO:0006366 IEA
    mitochondrial transcription GO:0006390 IEA
    positive regulation of interferon-beta production GO:0032728 IMP
    plastid transcription GO:0042793 IEA
    snRNA transcription by RNA polymerase III GO:0042796 IDA
    innate immune response GO:0045087 IEA
    positive regulation of innate immune response GO:0045089 IMP
    defense response to virus GO:0051607 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    RNA polymerase III complex GO:0005666 IBA
    RNA polymerase III complex GO:0005666 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified POLR3B in exosomes
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLR3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 APPL2 55198
Affinity Capture-MS Homo sapiens
5 TRMT1L 81627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CD3EAP  
Affinity Capture-MS Homo sapiens
7 Ruvbl1 56505
Affinity Capture-MS Mus musculus
8 KPNA1 3836
Cross-Linking-MS (XL-MS) Homo sapiens
9 ATG9A 79065
Proximity Label-MS Homo sapiens
10 MRPL17  
Co-fractionation Homo sapiens
11 P4HA2 8974
Affinity Capture-MS Homo sapiens
12 C9orf78 51759
Affinity Capture-MS Homo sapiens
13 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
14 LOC101060521 101060521
Co-fractionation Homo sapiens
15 URI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GSK3A 2931
Affinity Capture-MS Homo sapiens
17 PPP1CC 5501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 POLR2I 5438
Affinity Capture-MS Homo sapiens
19 POLR3G  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 POLR1E  
Affinity Capture-MS Homo sapiens
21 CRCP  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 Naa11  
Affinity Capture-MS Mus musculus
23 POLR2C 5432
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
24 GPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 POLR2M  
Affinity Capture-MS Homo sapiens
26 ASNSD1  
Affinity Capture-MS Homo sapiens
27 PFDN6 10471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EEF1A1 1915
Co-fractionation Homo sapiens
29 UVRAG  
Affinity Capture-MS Homo sapiens
30 MED4 29079
Affinity Capture-MS Homo sapiens
31 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PPP1CA 5499
Affinity Capture-MS Homo sapiens
34 RPL30 6156
Co-fractionation Homo sapiens
35 UXT 8409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 POLR3K  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 PSME1 5720
Affinity Capture-MS Homo sapiens
39 POLR3F  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
40 BDP1  
Affinity Capture-MS Homo sapiens
41 PFDN2 5202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 NOB1  
Co-fractionation Homo sapiens
44 HECTD1 25831
Affinity Capture-MS Homo sapiens
45 POLR2B 5431
Affinity Capture-MS Homo sapiens
46 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
47 POLR2A 5430
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 POLR3GL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 IPO9 55705
Co-fractionation Homo sapiens
50 DSN1 79980
Affinity Capture-MS Homo sapiens
51 POLR2J  
Affinity Capture-MS Homo sapiens
52 BRF1  
Affinity Capture-MS Homo sapiens
53 POLR3A 11128
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
54 POLR2H 5437
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
55 MAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SMARCA5 8467
Co-fractionation Homo sapiens
57 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
58 RPRD2  
Affinity Capture-MS Homo sapiens
59 RPRD1A  
Affinity Capture-MS Homo sapiens
60 POLR2D  
Affinity Capture-MS Homo sapiens
61 RIPK4  
Affinity Capture-MS Homo sapiens
62 POLR3E 55718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NXF1 10482
Affinity Capture-RNA Homo sapiens
64 TBP  
Affinity Capture-MS Homo sapiens
65 FKBP5 2289
Affinity Capture-MS Homo sapiens
66 RPA3 6119
Proximity Label-MS Homo sapiens
67 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
68 RPAP3 79657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 POLR1A  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
70 MATR3 9782
Affinity Capture-MS Homo sapiens
71 TSR1 55720
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
72 BRD3 8019
Affinity Capture-MS Homo sapiens
73 RAE1 8480
Affinity Capture-MS Homo sapiens
74 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
75 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RRS1 23212
Co-fractionation Homo sapiens
77 TP53 7157
Affinity Capture-MS Homo sapiens
78 POLR1B 84172
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
79 POLR2L 5441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 APOBEC3D  
Affinity Capture-MS Homo sapiens
81 POLR3C 10623
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 POLR1C 9533
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 WDR92 116143
Affinity Capture-MS Homo sapiens
84 POLR3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 RPAP1  
Affinity Capture-MS Homo sapiens
86 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 MAGEA9  
Affinity Capture-MS Homo sapiens
88 MKI67  
Affinity Capture-MS Homo sapiens
89 SKAP1 8631
Affinity Capture-MS Homo sapiens
90 Actr1b 226977
Affinity Capture-MS Mus musculus
91 MOV10 4343
Affinity Capture-RNA Homo sapiens
92 POLR3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
93 RPRD1B 58490
Affinity Capture-MS Homo sapiens
94 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 ZNRD1  
Affinity Capture-MS Homo sapiens
96 PTGES3 10728
Affinity Capture-MS Homo sapiens
97 KRAS 3845
Negative Genetic Homo sapiens
98 POLR1D 51082
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
99 RBP4 5950
Affinity Capture-MS Homo sapiens
100 PDRG1  
Affinity Capture-MS Homo sapiens
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