Gene description for DSN1
Gene name DSN1, MIS12 kinetochore complex component
Gene symbol DSN1
Other names/aliases C20orf172
KNL3
MIS13
dJ469A13.2
hKNL-3
Species Homo sapiens
 Database cross references - DSN1
ExoCarta ExoCarta_79980
Vesiclepedia VP_79980
Entrez Gene 79980
HGNC 16165
MIM 609175
UniProt Q9H410  
 DSN1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for DSN1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    small GTPase mediated signal transduction GO:0007264 TAS
    mitotic cell cycle GO:0000278 TAS
    cell division GO:0051301 IEA
    mitotic nuclear division GO:0007067 IEA
    chromosome segregation GO:0007059 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    MIS12/MIND type complex GO:0000444 IDA
 Experiment description of studies that identified DSN1 in exosomes
1
Experiment ID 193
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DSN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CASC5  
Affinity Capture-MS Homo sapiens
2 PMF1  
Affinity Capture-MS Homo sapiens
3 MIS12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 ZWINT  
Affinity Capture-Western Homo sapiens
5 CBX3 11335
Affinity Capture-MS Homo sapiens
6 C1orf48  
Affinity Capture-MS Homo sapiens
7 NSL1  
Affinity Capture-Western Homo sapiens
8 CBX5 23468
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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