ExoCarta: Gene summary

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Gene description for KIF2B
Gene name	kinesin family member 2B
Gene symbol	KIF2B
Other names/aliases	-
Species	Homo sapiens
Database cross references - KIF2B
ExoCarta	ExoCarta_84643
Vesiclepedia	VP_84643
Entrez Gene	84643
HGNC	29443
MIM	615142
UniProt	Q8N4N8
KIF2B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for KIF2B

Molecular Function
	microtubule motor activity	GO:0003777	IBA
	ATP binding	GO:0005524	IEA
	microtubule binding	GO:0008017	IBA
	ATP hydrolysis activity	GO:0016887	IBA
Biological Process
	microtubule-based movement	GO:0007018	IBA
	microtubule depolymerization	GO:0007019	IMP
	microtubule depolymerization	GO:0007019	TAS
	cell division	GO:0051301	IEA
	metaphase chromosome alignment	GO:0051310	IMP
	regulation of chromosome segregation	GO:0051983	IMP
Subcellular Localization
	kinetochore	GO:0000776	IEA
	nucleolus	GO:0005730	IDA
	cytoplasm	GO:0005737	IBA
	centrosome	GO:0005813	IBA
	spindle	GO:0005819	IBA
	cytosol	GO:0005829	TAS
	kinesin complex	GO:0005871	IBA
	microtubule	GO:0005874	IBA
	microtubule cytoskeleton	GO:0015630	IDA
	intercellular bridge	GO:0045171	IDA
	mitotic spindle	GO:0072686	IDA

Experiment description of studies that identified KIF2B in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for KIF2B

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

DSN1

79980

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

TMEM164

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MIS12

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TXLNA

200081

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDC26

246184

Affinity Capture-MS

Homo sapiens

STK3

6788

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANAPC16

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ACSBG2

Affinity Capture-MS

Homo sapiens

COMMD6

170622

Affinity Capture-MS

Homo sapiens

POLR2J

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SIKE1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COMMD8

54951

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CEP170

9859

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ASB6

140459

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SPC24

147841

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COMMD2

51122

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC93

54520

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDC23

8697

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KLC1

3831

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FEM1B

10116

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HOMER1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KLC4

89953

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NEK1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BACH1

571

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SPC25

57405

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

C4orf46

Affinity Capture-MS

Homo sapiens

WDR62

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ACACA

Positive Genetic

Homo sapiens

ANKRD52

283373

Affinity Capture-MS

Homo sapiens

TXLNG

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDC16

8881

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

C21orf2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KIF18B

146909

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CEP170B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DAPK3

1613

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SAV1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZG16B

124220

Affinity Capture-MS

Homo sapiens

CCDC22

28952

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

STK4

6789

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COMMD1

150684

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VPS8

23355

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

COMMD3

23412

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HERC2

8924

Affinity Capture-MS

Homo sapiens

CDC27

996

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KIF2C

11004

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which KIF2B is involved

Pathway	Evidence	Source
Adaptive Immune System	TAS	Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	TAS	Reactome
Amplification of signal from the kinetochores	TAS	Reactome
Cell Cycle	TAS	Reactome
Cell Cycle Checkpoints	TAS	Reactome
Cell Cycle, Mitotic	TAS	Reactome
COPI-dependent Golgi-to-ER retrograde traffic	TAS	Reactome
EML4 and NUDC in mitotic spindle formation	TAS	Reactome
Factors involved in megakaryocyte development and platelet production	TAS	Reactome
Golgi-to-ER retrograde transport	TAS	Reactome
Hemostasis	TAS	Reactome
Immune System	TAS	Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic	TAS	Reactome
Kinesins	TAS	Reactome
M Phase	TAS	Reactome
Membrane Trafficking	TAS	Reactome
MHC class II antigen presentation	TAS	Reactome
Mitotic Anaphase	TAS	Reactome
Mitotic Metaphase and Anaphase	TAS	Reactome
Mitotic Prometaphase	TAS	Reactome
Mitotic Spindle Checkpoint	TAS	Reactome
Resolution of Sister Chromatid Cohesion	TAS	Reactome
RHO GTPase Effectors	TAS	Reactome
RHO GTPases Activate Formins	TAS	Reactome
Separation of Sister Chromatids	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by Rho GTPases	TAS	Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	TAS	Reactome
Vesicle-mediated transport	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here