Gene description for HERC2
Gene name	HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene symbol	HERC2
Other names/aliases	D15F37S1 MRT38 SHEP1 jdf2 p528
Species	Homo sapiens
Database cross references - HERC2
ExoCarta	ExoCarta_8924
Entrez Gene	8924
HGNC	4868
MIM	605837
UniProt	O95714
HERC2 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for HERC2

Molecular Function     ubiquitin protein ligase binding GO:0031625 IPI     zinc ion binding GO:0008270 IEA     SUMO binding GO:0032183 IDA     protein binding GO:0005515 IPI     guanyl-nucleotide exchange factor activity GO:0005085 NAS     ligase activity GO:0016874 IEA     ubiquitin-protein transferase activity GO:0004842 IDA Biological Process     cellular protein metabolic process GO:0044267 TAS     spermatogenesis GO:0007283 IEA     protein ubiquitination GO:0016567 IDA     protein sumoylation GO:0016925 TAS     cellular response to DNA damage stimulus GO:0006974 IDA     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA     post-translational protein modification GO:0043687 TAS     intracellular protein transport GO:0006886 NAS     DNA repair GO:0006281 IDA     positive regulation of GTPase activity GO:0043547 NAS Subcellular Localization     membrane GO:0016020 IDA     cytoplasm GO:0005737 IDA     mitochondrial inner membrane GO:0005743 IEA     nucleus GO:0005634 IDA     centriole GO:0005814 IEA     nucleoplasm GO:0005654 TAS