Gene description for APBA2
Gene name amyloid beta (A4) precursor protein-binding, family A, member 2
Gene symbol APBA2
Other names/aliases D15S1518E
HsT16821
LIN-10
MGC:14091
MINT2
X11-BETA
X11L
Species Homo sapiens
 Database cross references - APBA2
ExoCarta ExoCarta_321
Vesiclepedia VP_321
Entrez Gene 321
HGNC 579
MIM 602712
UniProt Q99767  
 APBA2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for APBA2
Molecular Function
    amyloid-beta binding GO:0001540 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    in utero embryonic development GO:0001701 IEA
    chemical synaptic transmission GO:0007268 IBA
    nervous system development GO:0007399 TAS
    locomotory behavior GO:0007626 IEA
    regulation of gene expression GO:0010468 IEA
    protein transport GO:0015031 IEA
    multicellular organism growth GO:0035264 IEA
    presynaptic modulation of chemical synaptic transmission GO:0099171 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IBA
    dendritic spine GO:0043197 IBA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified APBA2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for APBA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSEN2 5664
Affinity Capture-Western Homo sapiens
2 RELA 5970
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 RNF43  
Proximity Label-MS Homo sapiens
4 C2CD4B  
Affinity Capture-MS Homo sapiens
5 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 IQSEC1 9922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ATG9A 79065
Proximity Label-MS Homo sapiens
9 STXBP1 6812
Reconstituted Complex Homo sapiens
10 TRIM41 90933
Affinity Capture-MS Homo sapiens
11 RLIM 51132
Affinity Capture-MS Homo sapiens
12 DMWD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CLSTN1 22883
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
15 PLD1 5337
Affinity Capture-MS Homo sapiens
16 APP 351
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
17 LRP1 4035
Two-hybrid Homo sapiens
18 AAGAB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MAPK6  
Two-hybrid Homo sapiens
20 NECAB3 63941
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 SP110  
Affinity Capture-MS Homo sapiens
22 DDX24 57062
Affinity Capture-MS Homo sapiens
23 LRP2 4036
Two-hybrid Homo sapiens
24 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TJAP1 93643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZNF518A 9849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 APBA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 APEX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SLC31A1 1317
Affinity Capture-MS Homo sapiens
30 SYT2  
Affinity Capture-MS Homo sapiens
31 USP20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 USP33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 IQSEC2 23096
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LOC388882  
Affinity Capture-MS Homo sapiens
35 LRP8 7804
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which APBA2 is involved
PathwayEvidenceSource
Neurexins and neuroligins IEA Reactome
Neuronal System IEA Reactome
Protein-protein interactions at synapses IEA Reactome





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