Gene description for APBA2
Gene name amyloid beta (A4) precursor protein-binding, family A, member 2
Gene symbol APBA2
Other names/aliases D15S1518E
HsT16821
LIN-10
MGC:14091
MINT2
X11-BETA
X11L
Species Homo sapiens
 Database cross references - APBA2
ExoCarta ExoCarta_321
Entrez Gene 321
HGNC 579
MIM 602712
UniProt Q99767  
 APBA2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for APBA2
Molecular Function
    protein binding GO:0005515 IPI
    beta-amyloid binding GO:0001540 IEA
Biological Process
    regulation of gene expression GO:0010468 IEA
    locomotory behavior GO:0007626 IEA
    protein transport GO:0015031 IEA
    in utero embryonic development GO:0001701 IEA
    synaptic transmission GO:0007268 IEA
    nervous system development GO:0007399 TAS
    multicellular organism growth GO:0035264 IEA
Subcellular Localization
    synaptic vesicle GO:0008021 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified APBA2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for APBA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 PSEN2  
Affinity Capture-Western Homo sapiens
3 LRP2 4036
Two-hybrid Homo sapiens
4 LRP8  
Two-hybrid Homo sapiens
5 LRP1 4035
Two-hybrid Homo sapiens
6 NRXN1  
Invitro Homo sapiens
7 NECAB3 63941
Affinity Capture-Western Homo sapiens
8 RELA  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 CLSTN1 22883
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which APBA2 is involved
No pathways found





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