Gene description for SLC31A1
Gene name solute carrier family 31 (copper transporter), member 1
Gene symbol SLC31A1
Other names/aliases COPT1
CTR1
Species Homo sapiens
 Database cross references - SLC31A1
ExoCarta ExoCarta_1317
Vesiclepedia VP_1317
Entrez Gene 1317
HGNC 11016
MIM 603085
UniProt O15431  
 SLC31A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
 Gene ontology annotations for SLC31A1
Molecular Function
    copper ion transmembrane transporter activity GO:0005375 IDA
    copper ion transmembrane transporter activity GO:0005375 TAS
    copper ion binding GO:0005507 IDA
    protein binding GO:0005515 IPI
    silver ion transmembrane transporter activity GO:0015080 IDA
    silver ion transmembrane transporter activity GO:0015080 ISS
    identical protein binding GO:0042802 IPI
    xenobiotic transmembrane transporter activity GO:0042910 ISS
Biological Process
    angiogenesis GO:0001525 IMP
    angiogenesis GO:0001525 ISS
    copper ion transport GO:0006825 TAS
    intracellular copper ion homeostasis GO:0006878 IEA
    copper ion import GO:0015677 IDA
    copper ion import GO:0015677 ISS
    plasma membrane copper ion transport GO:0015679 IDA
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 IMP
    xenobiotic transport GO:0042908 IDA
    xenobiotic transport GO:0042908 ISS
    protein complex oligomerization GO:0051259 IDA
    establishment of localization in cell GO:0051649 IEA
    silver ion transmembrane transport GO:1902601 IDA
    silver ion transmembrane transport GO:1902601 ISS
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    intercalated disc GO:0014704 IEA
    basolateral plasma membrane GO:0016323 ISS
    apical plasma membrane GO:0016324 ISS
    early endosome membrane GO:0031901 IDA
    late endosome membrane GO:0031902 IEA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified SLC31A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for SLC31A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TM4SF5  
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 FAM208A  
Affinity Capture-MS Homo sapiens
4 PRKAA1 5562
Affinity Capture-Western Homo sapiens
5 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
6 SLC31A2  
Affinity Capture-MS Homo sapiens
7 TMEM151A 256472
Affinity Capture-MS Homo sapiens
8 LGR4 55366
Affinity Capture-MS Homo sapiens
9 PMS1  
Affinity Capture-MS Homo sapiens
10 PRIM2 5558
Affinity Capture-MS Homo sapiens
11 ARHGEF39 84904
Affinity Capture-MS Homo sapiens
12 WASF2 10163
Affinity Capture-MS Homo sapiens
13 AXL 558
Affinity Capture-MS Homo sapiens
14 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FBXL19  
Affinity Capture-MS Homo sapiens
16 APBA3  
Affinity Capture-MS Homo sapiens
17 SHB 6461
Affinity Capture-MS Homo sapiens
18 FMN2  
Affinity Capture-MS Homo sapiens
19 NIT1 4817
Affinity Capture-MS Homo sapiens
20 ST3GAL2 6483
Affinity Capture-MS Homo sapiens
21 BMPR1A 657
Affinity Capture-MS Homo sapiens
22 MARC2 54996
Affinity Capture-MS Homo sapiens
23 TMEM200A 114801
Affinity Capture-MS Homo sapiens
24 AGAP3 116988
Affinity Capture-MS Homo sapiens
25 PDE2A  
Affinity Capture-MS Homo sapiens
26 IL1RAP 3556
Affinity Capture-MS Homo sapiens
27 CD320 51293
Affinity Capture-MS Homo sapiens
28 PLEKHG4  
Affinity Capture-MS Homo sapiens
29 L2HGDH  
Affinity Capture-MS Homo sapiens
30 INPP4B 8821
Affinity Capture-MS Homo sapiens
31 ZRANB3  
Affinity Capture-MS Homo sapiens
32 CCS 9973
Affinity Capture-Western Homo sapiens
33 ADCY6 112
Affinity Capture-MS Homo sapiens
34 CYB5R1 51706
Affinity Capture-MS Homo sapiens
35 KLHDC10 23008
Affinity Capture-MS Homo sapiens
36 RAB13 5872
Affinity Capture-MS Homo sapiens
37 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
39 PUSL1  
Affinity Capture-MS Homo sapiens
40 PRIM1  
Affinity Capture-MS Homo sapiens
41 SLC31A1 1317
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 NSUN3  
Affinity Capture-MS Homo sapiens
43 GAK 2580
Affinity Capture-MS Homo sapiens
44 ACVR2B  
Affinity Capture-MS Homo sapiens
45 HELZ2  
Affinity Capture-MS Homo sapiens
46 EXD2  
Affinity Capture-MS Homo sapiens
47 PEAK1 79834
Affinity Capture-MS Homo sapiens
48 AIFM1 9131
Co-fractionation Homo sapiens
49 CEP57  
Affinity Capture-MS Homo sapiens
50 XRCC3  
Affinity Capture-MS Homo sapiens
51 DHODH 1723
Affinity Capture-MS Homo sapiens
52 SLC25A31 83447
Affinity Capture-MS Homo sapiens
53 MARK4  
Affinity Capture-MS Homo sapiens
54 GUCD1  
Affinity Capture-MS Homo sapiens
55 FTSJ2 29960
Affinity Capture-MS Homo sapiens
56 SLC12A7 10723
Affinity Capture-MS Homo sapiens
57 DPH1  
Affinity Capture-MS Homo sapiens
58 PLEKHH3  
Affinity Capture-MS Homo sapiens
59 KIAA1804  
Affinity Capture-MS Homo sapiens
60 AGBL5  
Affinity Capture-MS Homo sapiens
61 SLC30A1 7779
Affinity Capture-MS Homo sapiens
62 AURKA 6790
Affinity Capture-MS Homo sapiens
63 ZNF268  
Affinity Capture-MS Homo sapiens
64 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 POLD1 5424
Affinity Capture-MS Homo sapiens
66 BRIP1  
Affinity Capture-MS Homo sapiens
67 AMMECR1  
Affinity Capture-MS Homo sapiens
68 SLC5A6 8884
Affinity Capture-MS Homo sapiens
69 SBF2 81846
Affinity Capture-MS Homo sapiens
70 NUS1  
Affinity Capture-MS Homo sapiens
71 ERBB3 2065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CEP295  
Affinity Capture-MS Homo sapiens
73 RAB4A 5867
Affinity Capture-MS Homo sapiens
74 SNAP47 116841
Affinity Capture-MS Homo sapiens
75 ACP2 53
Affinity Capture-MS Homo sapiens
76 MCM10 55388
Affinity Capture-MS Homo sapiens
77 POGZ 23126
Affinity Capture-MS Homo sapiens
78 LIN7C 55327
Affinity Capture-MS Homo sapiens
79 SAR1B 51128
Affinity Capture-MS Homo sapiens
80 WNT5A 7474
Affinity Capture-MS Homo sapiens
81 ARL17A  
Affinity Capture-MS Homo sapiens
82 PLXDC2 84898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 KIAA0391  
Affinity Capture-MS Homo sapiens
84 NMT2 9397
Affinity Capture-MS Homo sapiens
85 MTMR1 8776
Affinity Capture-MS Homo sapiens
86 PIK3R1 5295
Affinity Capture-MS Homo sapiens
87 ARL13B 200894
Affinity Capture-MS Homo sapiens
88 MPP7 143098
Affinity Capture-MS Homo sapiens
89 ATP2C1 27032
Affinity Capture-MS Homo sapiens
90 PRKAB1 5564
Biochemical Activity Homo sapiens
91 ACSL4 2182
Affinity Capture-MS Homo sapiens
92 TTC31  
Affinity Capture-MS Homo sapiens
93 TAF6L 10629
Affinity Capture-MS Homo sapiens
94 NEIL3  
Affinity Capture-MS Homo sapiens
95 RTEL1 51750
Affinity Capture-MS Homo sapiens
96 ENDOG  
Affinity Capture-MS Homo sapiens
97 DDR1 780
Affinity Capture-MS Homo sapiens
98 C2orf72  
Affinity Capture-MS Homo sapiens
99 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
100 DTL  
Affinity Capture-MS Homo sapiens
101 DIP2B 57609
Affinity Capture-MS Homo sapiens
102 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
103 HBS1L 10767
Affinity Capture-MS Homo sapiens
104 CTU1 90353
Affinity Capture-MS Homo sapiens
105 DIP2A 23181
Affinity Capture-MS Homo sapiens
106 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 SMG8 55181
Affinity Capture-MS Homo sapiens
108 ZNF598 90850
Affinity Capture-MS Homo sapiens
109 DLG1 1739
Affinity Capture-MS Homo sapiens
110 ELP3 55140
Affinity Capture-MS Homo sapiens
111 CERK 64781
Affinity Capture-MS Homo sapiens
112 ACVR2A  
Affinity Capture-MS Homo sapiens
113 DAB2IP 153090
Affinity Capture-MS Homo sapiens
114 ACAD10  
Affinity Capture-MS Homo sapiens
115 EGFR 1956
Negative Genetic Homo sapiens
116 PDPK1 5170
Affinity Capture-MS Homo sapiens
117 TLDC1 57707
Affinity Capture-MS Homo sapiens
118 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
119 SNX9 51429
Affinity Capture-MS Homo sapiens
120 NXF1 10482
Affinity Capture-RNA Homo sapiens
121 CYP51A1 1595
Affinity Capture-MS Homo sapiens
122 CDC42BPA 8476
Affinity Capture-MS Homo sapiens
123 PI4K2B 55300
Affinity Capture-MS Homo sapiens
124 RETSAT 54884
Affinity Capture-MS Homo sapiens
125 C4orf29 80167
Affinity Capture-MS Homo sapiens
126 RHBDF2 79651
Affinity Capture-MS Homo sapiens
127 RELT  
Affinity Capture-MS Homo sapiens
128 MTOR 2475
Affinity Capture-MS Homo sapiens
129 FAR2  
Affinity Capture-MS Homo sapiens
130 PIK3CA 5290
Affinity Capture-MS Homo sapiens
131 MYO9A 4649
Affinity Capture-MS Homo sapiens
132 NMD3 51068
Affinity Capture-MS Homo sapiens
133 B3GAT3 26229
Affinity Capture-MS Homo sapiens
134 PI4K2A 55361
Affinity Capture-MS Homo sapiens
135 WDR44 54521
Affinity Capture-MS Homo sapiens
136 DTWD1  
Affinity Capture-MS Homo sapiens
137 DCAF15  
Affinity Capture-MS Homo sapiens
138 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 OSMR 9180
Affinity Capture-MS Homo sapiens
140 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
141 PHGDH 26227
Affinity Capture-MS Homo sapiens
142 TRAPPC6B 122553
Affinity Capture-MS Homo sapiens
143 DENND6A 201627
Affinity Capture-MS Homo sapiens
144 MZB1  
Affinity Capture-MS Homo sapiens
145 ARRB2 409
Affinity Capture-MS Homo sapiens
146 SEC23IP 11196
Affinity Capture-MS Homo sapiens
147 ZNF592 9640
Affinity Capture-MS Homo sapiens
148 GRK6 2870
Affinity Capture-MS Homo sapiens
149 ABCB8 11194
Affinity Capture-MS Homo sapiens
150 SLC12A4 6560
Affinity Capture-MS Homo sapiens
151 SBF1 6305
Affinity Capture-MS Homo sapiens
152 PTPRD 5789
Affinity Capture-MS Homo sapiens
153 DSTYK 25778
Affinity Capture-MS Homo sapiens
154 PIK3R2 5296
Affinity Capture-MS Homo sapiens
155 KLHDC3  
Affinity Capture-MS Homo sapiens
156 ARF5 381
Affinity Capture-MS Homo sapiens
157 NSDHL 50814
Affinity Capture-MS Homo sapiens
158 PRKAG2 51422
Biochemical Activity Homo sapiens
159 THAP11 57215
Affinity Capture-MS Homo sapiens
160 NISCH 11188
Affinity Capture-MS Homo sapiens
161 SNRK  
Affinity Capture-MS Homo sapiens
162 DDX58 23586
Affinity Capture-RNA Homo sapiens
163 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
164 USP30  
Affinity Capture-MS Homo sapiens
165 DDX11 1663
Affinity Capture-MS Homo sapiens
166 DGKZ  
Affinity Capture-MS Homo sapiens
167 MOV10 4343
Affinity Capture-RNA Homo sapiens
168 WDR76  
Affinity Capture-MS Homo sapiens
169 ADCK1  
Affinity Capture-MS Homo sapiens
170 APBA2 321
Affinity Capture-MS Homo sapiens
171 LIN54  
Affinity Capture-MS Homo sapiens
172 HSDL1 83693
Affinity Capture-MS Homo sapiens
173 FOXM1  
Affinity Capture-MS Homo sapiens
174 PLD1 5337
Affinity Capture-MS Homo sapiens
175 CISD2 493856
Affinity Capture-MS Homo sapiens
176 KRAS 3845
Synthetic Lethality Homo sapiens
177 CC2D1A 54862
Affinity Capture-MS Homo sapiens
178 LIMK2 3985
Affinity Capture-MS Homo sapiens
179 FBXL17  
Affinity Capture-MS Homo sapiens
180 USP32 84669
Affinity Capture-MS Homo sapiens
181 UBE3D  
Affinity Capture-MS Homo sapiens
182 DNAH14  
Affinity Capture-MS Homo sapiens
183 PIK3R3 8503
Affinity Capture-MS Homo sapiens
184 ESCO2  
Affinity Capture-MS Homo sapiens
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