Gene description for PIK3CA
Gene name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene symbol	PIK3CA
Other names/aliases	CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha
Species	Homo sapiens
Database cross references - PIK3CA
ExoCarta	ExoCarta_5290
Entrez Gene	5290
HGNC	8975
MIM	171834
UniProt	P42336
PIK3CA identified in exosomes derived from the following tissue/cell type
Nasopharyngeal carcinoma cells	21059916

Gene ontology annotations for PIK3CA

Molecular Function     phosphatidylinositol 3-kinase activity GO:0035004 TAS     protein serine/threonine kinase activity GO:0004674 IEA     kinase activity GO:0016301 TAS     phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 TAS     1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 IBA     protein kinase activator activity GO:0030295 IEA     insulin receptor substrate binding GO:0043560 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     1-phosphatidylinositol-3-kinase activity GO:0016303 IDA Biological Process     phospholipid metabolic process GO:0006644 TAS     protein phosphorylation GO:0006468 IBA     positive regulation of protein kinase activity GO:0045860 IEA     phosphatidylinositol 3-kinase signaling GO:0014065 IBA     insulin receptor signaling pathway GO:0008286 TAS     activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP     T cell costimulation GO:0031295 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     cell chemotaxis GO:0060326 IBA     hypomethylation of CpG island GO:0044029 IEA     negative regulation of anoikis GO:2000811 IMP     inflammatory response GO:0006954 IBA     small molecule metabolic process GO:0044281 TAS     negative regulation of fibroblast apoptotic process GO:2000270 IEA     innate immune response GO:0045087 TAS     adaptive immune response GO:0002250 IBA     vasculature development GO:0001944 TAS     phosphatidylinositol phosphorylation GO:0046854 ISS     T cell receptor signaling pathway GO:0050852 TAS     cardiac muscle contraction GO:0060048 TAS     phosphatidylinositol biosynthetic process GO:0006661 TAS     phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IBA     leukocyte migration GO:0050900 TAS     platelet activation GO:0030168 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     angiogenesis GO:0001525 IEA     glucose metabolic process GO:0006006 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     endothelial cell migration GO:0043542 TAS     regulation of genetic imprinting GO:2000653 IEA     regulation of multicellular organism growth GO:0040014 IEA     protein kinase B signaling GO:0043491 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 TAS     blood coagulation GO:0007596 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS Subcellular Localization     phosphatidylinositol 3-kinase complex, class IA GO:0005943 IDA     plasma membrane GO:0005886 IBA     phosphatidylinositol 3-kinase complex GO:0005942 ISS     cytoplasm GO:0005737 IBA     cytosol GO:0005829 TAS     lamellipodium GO:0030027 IEA