Gene description for SUN2
Gene name Sad1 and UNC84 domain containing 2
Gene symbol SUN2
Other names/aliases UNC84B
Species Homo sapiens
 Database cross references - SUN2
ExoCarta ExoCarta_25777
Vesiclepedia VP_25777
Entrez Gene 25777
HGNC 14210
MIM 613569
UniProt Q9UH99  
 SUN2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SUN2
Molecular Function
    protein binding GO:0005515 IPI
    lamin binding GO:0005521 IDA
    microtubule binding GO:0008017 TAS
    identical protein binding GO:0042802 IPI
    protein-membrane adaptor activity GO:0043495 IBA
    cytoskeleton-nuclear membrane anchor activity GO:0140444 IDA
Biological Process
    mitotic spindle organization GO:0007052 TAS
    nuclear migration GO:0007097 TAS
    nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration GO:0021817 IEA
    positive regulation of cell migration GO:0030335 ISS
    nuclear migration along microfilament GO:0031022 ISS
    meiotic cell cycle GO:0051321 IEA
    centrosome localization GO:0051642 ISS
    nuclear matrix anchoring at nuclear membrane GO:0090292 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 IEA
    condensed nuclear chromosome GO:0000794 IEA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 TAS
    nuclear inner membrane GO:0005637 IEA
    endosome membrane GO:0010008 IEA
    nuclear membrane GO:0031965 IDA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IBA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IDA
 Experiment description of studies that identified SUN2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SUN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRP3  
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 PRKAA1 5562
Affinity Capture-MS Homo sapiens
6 CD1A 909
Affinity Capture-MS Homo sapiens
7 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KLK15  
Affinity Capture-MS Homo sapiens
9 METTL7A 25840
Proximity Label-MS Homo sapiens
10 HPN  
Affinity Capture-MS Homo sapiens
11 RPA2 6118
Proximity Label-MS Homo sapiens
12 CTDNEP1 23399
Proximity Label-MS Homo sapiens
13 CFC1  
Affinity Capture-MS Homo sapiens
14 BSCL2  
Affinity Capture-MS Homo sapiens
15 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
16 ECEL1  
Affinity Capture-MS Homo sapiens
17 SYNE2 23224
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
18 TNFSF18 8995
Affinity Capture-MS Homo sapiens
19 SOX2  
Affinity Capture-MS Homo sapiens
20 POTEF 728378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KIAA1429 25962
Affinity Capture-MS Homo sapiens
22 ARL6IP6  
Affinity Capture-MS Homo sapiens
23 RPS20 6224
Two-hybrid Homo sapiens
24 TM2D3  
Affinity Capture-MS Homo sapiens
25 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
27 SRSF10 10772
Two-hybrid Homo sapiens
28 COPB2 9276
Affinity Capture-MS Homo sapiens
29 C9orf3 84909
Co-crystal Structure Homo sapiens
30 METAP2 10988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CLEC2B  
Affinity Capture-MS Homo sapiens
32 AGO3  
Affinity Capture-MS Homo sapiens
33 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SSR1 6745
Proximity Label-MS Homo sapiens
35 PIGH  
Affinity Capture-MS Homo sapiens
36 RAB5B 5869
Two-hybrid Homo sapiens
37 LIPG 9388
Affinity Capture-MS Homo sapiens
38 MECP2 4204
Affinity Capture-MS Homo sapiens
39 SNX27 81609
Affinity Capture-MS Homo sapiens
40 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 BTNL2  
Affinity Capture-MS Homo sapiens
42 TMEM106A  
Affinity Capture-MS Homo sapiens
43 NEDD4 4734
Affinity Capture-MS Homo sapiens
44 TMEM87A 25963
Affinity Capture-MS Homo sapiens
45 HLA-G 3135
Affinity Capture-MS Homo sapiens
46 ACADS 35
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 LRRC59 55379
Proximity Label-MS Homo sapiens
49 PRPF6 24148
Two-hybrid Homo sapiens
50 PIP 5304
Affinity Capture-MS Homo sapiens
51 TSGA10IP  
Affinity Capture-MS Homo sapiens
52 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
53 IFITM3 10410
Affinity Capture-MS Homo sapiens
54 COPE 11316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CHMP6 79643
Affinity Capture-MS Homo sapiens
56 IDS  
Affinity Capture-MS Homo sapiens
57 SDF2L1 23753
Affinity Capture-MS Homo sapiens
58 NTRK1 4914
Affinity Capture-MS Homo sapiens
59 SYNE1 23345
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
60 DNAJB9 4189
Affinity Capture-MS Homo sapiens
61 CDHR4  
Affinity Capture-MS Homo sapiens
62 RPN1 6184
Proximity Label-MS Homo sapiens
63 SUMF1 285362
Affinity Capture-MS Homo sapiens
64 COPS7B 64708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 MAPK8 5599
Affinity Capture-MS Homo sapiens
66 ANKRD44 91526
Affinity Capture-MS Homo sapiens
67 SLC25A46 91137
Proximity Label-MS Homo sapiens
68 SEC61B 10952
Proximity Label-MS Homo sapiens
69 TMPRSS13  
Affinity Capture-MS Homo sapiens
70 GLTSCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 LY86  
Affinity Capture-MS Homo sapiens
72 SCARNA22  
Affinity Capture-RNA Homo sapiens
73 FBXL4 26235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 TJP1 7082
Affinity Capture-MS Homo sapiens
75 Rab5c 19345
Affinity Capture-MS Mus musculus
76 EPDR1 54749
Affinity Capture-MS Homo sapiens
77 MFAP4 4239
Affinity Capture-MS Homo sapiens
78 PCDHB7  
Affinity Capture-MS Homo sapiens
79 ENDOD1 23052
Affinity Capture-MS Homo sapiens
80 TP53BP1 7158
Affinity Capture-MS Homo sapiens
81 RAB5A 5868
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 LMNB1 4001
Proximity Label-MS Homo sapiens
83 RC3H2  
Affinity Capture-MS Homo sapiens
84 GGH 8836
Affinity Capture-MS Homo sapiens
85 GOLT1B 51026
Affinity Capture-MS Homo sapiens
86 PRG2  
Affinity Capture-MS Homo sapiens
87 PI15  
Affinity Capture-MS Homo sapiens
88 CBLN4  
Affinity Capture-MS Homo sapiens
89 CLEC4A  
Affinity Capture-MS Homo sapiens
90 DHH  
Affinity Capture-MS Homo sapiens
91 NRM 11270
Two-hybrid Homo sapiens
92 DNAJC25 548645
Proximity Label-MS Homo sapiens
93 IL5RA  
Affinity Capture-MS Homo sapiens
94 ELSPBP1  
Affinity Capture-MS Homo sapiens
95 KCNE3  
Affinity Capture-MS Homo sapiens
96 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 HGS 9146
Reconstituted Complex Homo sapiens
98 RPA3 6119
Proximity Label-MS Homo sapiens
99 CYP2J2  
Affinity Capture-MS Homo sapiens
100 PIK3CA 5290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 GXYLT1 283464
Affinity Capture-MS Homo sapiens
102 DNAJC1 64215
Proximity Label-MS Homo sapiens
103 LGI1  
Affinity Capture-MS Homo sapiens
104 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
105 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 LMNA 4000
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 PDE3A  
Affinity Capture-MS Homo sapiens
108 NEDD4L 23327
Affinity Capture-MS Homo sapiens
109 Fbxw11  
Affinity Capture-MS Mus musculus
110 HUWE1 10075
Affinity Capture-MS Homo sapiens
111 ADAM30 11085
Affinity Capture-MS Homo sapiens
112 UGP2 7360
Affinity Capture-MS Homo sapiens
113 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
114 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 TDRKH  
Affinity Capture-MS Homo sapiens
116 SCGB1D1  
Affinity Capture-MS Homo sapiens
117 UQCC1 55245
Affinity Capture-MS Homo sapiens
118 PNPLA7  
Affinity Capture-MS Homo sapiens
119 IGLL5 100423062
Affinity Capture-MS Homo sapiens
120 MEN1 4221
Affinity Capture-MS Homo sapiens
121 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 NHLRC2 374354
Affinity Capture-MS Homo sapiens
123 GOLGA7B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NCR3  
Affinity Capture-MS Homo sapiens
125 FKBP14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 SFTPC  
Affinity Capture-MS Homo sapiens
127 TACR3  
Affinity Capture-MS Homo sapiens
128 PLD3 23646
Affinity Capture-MS Homo sapiens
129 SIRPD  
Affinity Capture-MS Homo sapiens
130 SEC62 7095
Proximity Label-MS Homo sapiens
131 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 UGT1A7 54577
Affinity Capture-MS Homo sapiens
133 RAB7A 7879
Proximity Label-MS Homo sapiens
134 ALPP 250
Affinity Capture-MS Homo sapiens
135 DHRS4 10901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 BRD1 23774
Affinity Capture-MS Homo sapiens
137 ACVR1C  
Affinity Capture-MS Homo sapiens
138 EDN3  
Affinity Capture-MS Homo sapiens
139 RAB5C 5878
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 RC3H1 149041
Affinity Capture-MS Homo sapiens
141 CAV1 857
Affinity Capture-MS Homo sapiens
142 USP20  
Affinity Capture-MS Homo sapiens
143 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUN2 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Meiosis IEA Reactome
Meiotic synapsis IEA Reactome
Reproduction IEA Reactome





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