Gene description for FBXL4
Gene name F-box and leucine-rich repeat protein 4
Gene symbol FBXL4
Other names/aliases FBL4
FBL5
MTDPS13
Species Homo sapiens
 Database cross references - FBXL4
ExoCarta ExoCarta_26235
Vesiclepedia VP_26235
Entrez Gene 26235
HGNC 13601
MIM 605654
UniProt Q9UKA2  
 FBXL4 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for FBXL4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    autophagy of mitochondrion GO:0000422 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 TAS
    mitochondrion GO:0005739 HTP
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial intermembrane space GO:0005758 IDA
    cytosol GO:0005829 TAS
    nuclear speck GO:0016607 IDA
    SCF ubiquitin ligase complex GO:0019005 IBA
 Experiment description of studies that identified FBXL4 in exosomes
1
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for FBXL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARMC4  
Affinity Capture-MS Homo sapiens
2 CCDC151  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FAM26D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MTCH1 23787
Proximity Label-MS Homo sapiens
6 KRT1 3848
Affinity Capture-MS Homo sapiens
7 CALML3 810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PKM 5315
Affinity Capture-MS Homo sapiens
9 BBS7 55212
Affinity Capture-MS Homo sapiens
10 VDAC1 7416
Affinity Capture-MS Homo sapiens
11 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
12 BNIP3L  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 VHL  
Negative Genetic Homo sapiens
14 KDM4A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 POTEE 445582
Proximity Label-MS Homo sapiens
16 FIS1 51024
Proximity Label-MS Homo sapiens
17 EXOSC2 23404
Affinity Capture-MS Homo sapiens
18 HSPA2 3306
Affinity Capture-MS Homo sapiens
19 DUSP14 11072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ACPP 55
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TRABD 80305
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PROCR 10544
Affinity Capture-MS Homo sapiens
23 STIP1 10963
Affinity Capture-MS Homo sapiens
24 SUN2 25777
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 BNIP3 664
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 SLC25A46 91137
Proximity Label-MS Homo sapiens
27 ATG9B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MAVS 57506
Proximity Label-MS Homo sapiens
29 CUL1 8454
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 FAF2 23197
Affinity Capture-Western Homo sapiens
31 CLGN 1047
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 HSPA8 3312
Affinity Capture-MS Homo sapiens
33 CCT2 10576
Affinity Capture-MS Homo sapiens
34 PXMP2  
Proximity Label-MS Homo sapiens
35 PPM1B 5495
Affinity Capture-MS Homo sapiens
36 HEPHL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
38 MTCH2 23788
Proximity Label-MS Homo sapiens
39 GPNMB 10457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CPS1 1373
Affinity Capture-MS Homo sapiens
41 TUBA1B 10376
Affinity Capture-MS Homo sapiens
42 VCP 7415
Affinity Capture-Western Homo sapiens
43 KRT9 3857
Affinity Capture-MS Homo sapiens
44 DNAJA1 3301
Affinity Capture-MS Homo sapiens
45 GK  
Proximity Label-MS Homo sapiens
46 KIF11 3832
Affinity Capture-MS Homo sapiens
47 TTC9C 283237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ACTB 60
Affinity Capture-MS Homo sapiens
49 KRT2 3849
Affinity Capture-MS Homo sapiens
50 PDIA6 10130
Affinity Capture-MS Homo sapiens
51 RHOT2 89941
Proximity Label-MS Homo sapiens
52 FBXL4 26235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 LRRC15 131578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 HSPA5 3309
Affinity Capture-MS Homo sapiens
55 TUBB 203068
Affinity Capture-MS Homo sapiens
56 AIFM1 9131
Proximity Label-MS Homo sapiens
57 CANX 821
Affinity Capture-MS Homo sapiens
58 XPO1 7514
Affinity Capture-MS Homo sapiens
59 TUBB4B 10383
Affinity Capture-MS Homo sapiens
60 ERLEC1 27248
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 TXNRD1 7296
Affinity Capture-MS Homo sapiens
62 PDIA3 2923
Affinity Capture-MS Homo sapiens
63 FKBP8 23770
Proximity Label-MS Homo sapiens
64 MYO19  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
66 LPCAT3 10162
Affinity Capture-MS Homo sapiens
67 SERPINB5 5268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 OCIAD1 54940
Proximity Label-MS Homo sapiens
69 TOMM70A 9868
Affinity Capture-MS Homo sapiens
70 TUBA4A 7277
Affinity Capture-MS Homo sapiens
71 DNASE1L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 PADI3 51702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 Tpx2  
Affinity Capture-MS Mus musculus
74 SELENBP1 8991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
76 PLCD1 5333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 SIRT2 22933
Proximity Label-MS Homo sapiens
78 Nedd1  
Affinity Capture-MS Mus musculus
79 HSPD1 3329
Affinity Capture-MS Homo sapiens
80 HSPA9 3313
Affinity Capture-MS Homo sapiens
81 AKAP1 8165
Proximity Label-MS Homo sapiens
82 PKP3 11187
Affinity Capture-MS Homo sapiens
83 IMMT 10989
Affinity Capture-MS Homo sapiens
84 TUBB2A 7280
Affinity Capture-MS Homo sapiens
85 SUGT1 10910
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 FASN 2194
Positive Genetic Homo sapiens
Affinity Capture-MS Homo sapiens
87 CCT8 10694
Affinity Capture-MS Homo sapiens
88 STK38 11329
Affinity Capture-MS Homo sapiens
89 KRT10 3858
Affinity Capture-MS Homo sapiens
90 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CNPY2 10330
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 SKP1 6500
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 TUBB3 10381
Affinity Capture-MS Homo sapiens
94 VSIG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CRAT 1384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 S100A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
98 PKP1 5317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 TGM3 7053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 FLNA 2316
Affinity Capture-MS Homo sapiens
101 DSG4 147409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 NEU2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 VDAC3 7419
Affinity Capture-MS Homo sapiens
104 TRIM29 23650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 HSPA1B 3304
Affinity Capture-MS Homo sapiens
106 AIM1 202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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