Gene description for FBXL4
Gene name F-box and leucine-rich repeat protein 4
Gene symbol FBXL4
Other names/aliases FBL4
FBL5
MTDPS13
Species Homo sapiens
 Database cross references - FBXL4
ExoCarta ExoCarta_26235
Entrez Gene 26235
HGNC 13601
MIM 605654
UniProt Q9UKA2  
 FBXL4 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for FBXL4
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 TAS
    mitochondrial intermembrane space GO:0005758 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified FBXL4 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for FBXL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SKP1 6500
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which FBXL4 is involved
No pathways found





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