Gene description for PADI3
Gene name peptidyl arginine deiminase, type III
Gene symbol PADI3
Other names/aliases PAD3
PDI3
Species Homo sapiens
 Database cross references - PADI3
ExoCarta ExoCarta_51702
Vesiclepedia VP_51702
Entrez Gene 51702
HGNC 18337
MIM 606755
UniProt Q9ULW8  
 PADI3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PADI3
Molecular Function
    protein-arginine deiminase activity GO:0004668 IBA
    protein-arginine deiminase activity GO:0004668 IMP
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    histone H3R2 arginine deiminase activity GO:0140795 IEA
    histone H3R8 arginine deiminase activity GO:0140796 IEA
    histone H3R17 arginine deiminase activity GO:0140797 IEA
    histone H3R26 arginine deiminase activity GO:0140798 IEA
    histone H4R3 arginine deiminase activity GO:0140809 IEA
    histone H1R54 arginine deiminase activity GO:0140810 IEA
    histone H2AR3 arginine deiminase activity GO:0140811 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified PADI3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PADI3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLG2  
Affinity Capture-MS Homo sapiens
2 FBXL4 26235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 OAZ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SGOL2 151246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TEX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SPARCL1  
Affinity Capture-MS Homo sapiens
9 C1orf127  
Affinity Capture-MS Homo sapiens
10 INCA1  
Two-hybrid Homo sapiens
11 CAPZA2 830
Affinity Capture-MS Homo sapiens
12 PTDSS1 9791
Affinity Capture-MS Homo sapiens
13 PLD5  
Affinity Capture-MS Homo sapiens
14 NPSR1  
Affinity Capture-MS Homo sapiens
15 NFKB1 4790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RRAS2 22800
Affinity Capture-MS Homo sapiens
17 PEMT  
Affinity Capture-MS Homo sapiens
18 MAP1LC3A 84557
Affinity Capture-MS Homo sapiens
19 PADI4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 RAP1B 5908
Affinity Capture-MS Homo sapiens
21 PADI3 51702
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
23 KDELR2 11014
Affinity Capture-MS Homo sapiens
24 IL31RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 REL 5966
Two-hybrid Homo sapiens
26 RAB11B 9230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 FOS 2353
Affinity Capture-MS Homo sapiens
28 ANXA9  
Affinity Capture-MS Homo sapiens
29 LDLR 3949
Positive Genetic Homo sapiens
30 SGIP1  
Affinity Capture-MS Homo sapiens
31 PML 5371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PADI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CPLX3  
Affinity Capture-MS Homo sapiens
34 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 NFKB2 4791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NSMAF  
Affinity Capture-MS Homo sapiens
37 PYHIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PADI3 is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome





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