Gene description for KDELR2
Gene name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Gene symbol KDELR2
Other names/aliases ELP-1
ERD2.2
Species Homo sapiens
 Database cross references - KDELR2
ExoCarta ExoCarta_11014
Vesiclepedia VP_11014
Entrez Gene 11014
HGNC 6305
MIM 609024
UniProt P33947  
 KDELR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KDELR2
Molecular Function
    KDEL sequence binding GO:0005046 IDA
    ER retention sequence binding GO:0046923 IBA
Biological Process
    protein retention in ER lumen GO:0006621 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IDA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IMP
    protein transport GO:0015031 IEA
    maintenance of protein localization in endoplasmic reticulum GO:0035437 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cis-Golgi network GO:0005801 IBA
    membrane GO:0016020 ISS
    transport vesicle GO:0030133 TAS
    COPI-coated vesicle membrane GO:0030663 IDA
 Experiment description of studies that identified KDELR2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KDELR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 KIAA0368 23392
Affinity Capture-MS Homo sapiens
3 KDELR3 11015
Cross-Linking-MS (XL-MS) Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 LRRC15 131578
Affinity Capture-MS Homo sapiens
6 SELENBP1 8991
Affinity Capture-MS Homo sapiens
7 LYG2  
Affinity Capture-MS Homo sapiens
8 NAAA  
Affinity Capture-MS Homo sapiens
9 SLC2A1 6513
Affinity Capture-MS Homo sapiens
10 EDNRA 1909
Affinity Capture-MS Homo sapiens
11 HEPHL1  
Affinity Capture-MS Homo sapiens
12 TSSC1 7260
Affinity Capture-MS Homo sapiens
13 CALML3 810
Affinity Capture-MS Homo sapiens
14 CIAO1 9391
Affinity Capture-MS Homo sapiens
15 PPM1E  
Affinity Capture-MS Homo sapiens
16 OPALIN  
Affinity Capture-MS Homo sapiens
17 TNFSF8  
Affinity Capture-MS Homo sapiens
18 LRRC25  
Affinity Capture-MS Homo sapiens
19 EPN1 29924
Affinity Capture-MS Homo sapiens
20 TNFSF14  
Affinity Capture-MS Homo sapiens
21 MZT2B 80097
Affinity Capture-MS Homo sapiens
22 PRSS50  
Affinity Capture-MS Homo sapiens
23 VSIG8  
Affinity Capture-MS Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 GAA 2548
Affinity Capture-MS Homo sapiens
26 ZC3HC1  
Affinity Capture-MS Homo sapiens
27 CSNK1E 1454
Affinity Capture-MS Homo sapiens
28 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
29 FFAR1  
Affinity Capture-MS Homo sapiens
30 H2AFY 9555
Affinity Capture-MS Homo sapiens
31 KDELR1 10945
Cross-Linking-MS (XL-MS) Homo sapiens
32 ESR1  
Affinity Capture-MS Homo sapiens
33 GZMH  
Affinity Capture-MS Homo sapiens
34 PLCD1 5333
Affinity Capture-MS Homo sapiens
35 MLST8 64223
Affinity Capture-MS Homo sapiens
36 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
37 S100A3  
Affinity Capture-MS Homo sapiens
38 TBC1D32 221322
Proximity Label-MS Homo sapiens
39 GDPD3 79153
Affinity Capture-MS Homo sapiens
40 ESRRB  
Affinity Capture-MS Homo sapiens
41 PADI3 51702
Affinity Capture-MS Homo sapiens
42 NEFM 4741
Proximity Label-MS Homo sapiens
43 PKP1 5317
Affinity Capture-MS Homo sapiens
44 FAM91A1 157769
Affinity Capture-MS Homo sapiens
45 WDR11 55717
Affinity Capture-MS Homo sapiens
46 TMEM72  
Affinity Capture-MS Homo sapiens
47 MCM2 4171
Affinity Capture-MS Homo sapiens
48 ACPP 55
Affinity Capture-MS Homo sapiens
49 SERINC3 10955
Affinity Capture-MS Homo sapiens
50 RPUSD3  
Proximity Label-MS Homo sapiens
51 FAM174A 345757
Affinity Capture-MS Homo sapiens
52 GINM1 116254
Affinity Capture-MS Homo sapiens
53 DUSP14 11072
Affinity Capture-MS Homo sapiens
54 NEU2  
Affinity Capture-MS Homo sapiens
55 VIPR1  
Affinity Capture-MS Homo sapiens
56 PLP2 5355
Affinity Capture-MS Homo sapiens
57 POU5F1  
Affinity Capture-MS Homo sapiens
58 GNAI2 2771
Affinity Capture-MS Homo sapiens
59 TGM3 7053
Affinity Capture-MS Homo sapiens
60 TRIM29 23650
Affinity Capture-MS Homo sapiens
61 ATP2A3 489
Affinity Capture-MS Homo sapiens
62 KLK15  
Affinity Capture-MS Homo sapiens
63 DSG4 147409
Affinity Capture-MS Homo sapiens
64 FAM26D  
Affinity Capture-MS Homo sapiens
65 AIM1 202
Affinity Capture-MS Homo sapiens
66 TGM1 7051
Affinity Capture-MS Homo sapiens
67 BCOR  
Affinity Capture-MS Homo sapiens
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