Gene description for KDELR1
Gene name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Gene symbol KDELR1
Other names/aliases ERD2
Species Homo sapiens
 Database cross references - KDELR1
ExoCarta ExoCarta_10945
Entrez Gene 10945
HGNC 6304
MIM 131235
UniProt P24390  
 KDELR1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KDELR1
Molecular Function
    KDEL sequence binding GO:0005046 TAS
Biological Process
    intracellular protein transport GO:0006886 TAS
    protein retention in ER lumen GO:0006621 IEA
    vesicle-mediated transport GO:0016192 IEA
Subcellular Localization
    COPI-coated vesicle membrane GO:0030663 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    membrane GO:0016020 TAS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    cis-Golgi network GO:0005801 IEA
 Experiment description of studies that identified KDELR1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KDELR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WBP5  
Affinity Capture-MS Homo sapiens
2 COPB1 1315
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 NEK6 10783
Affinity Capture-MS Homo sapiens
4 KDELR1 10945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 SERINC3 10955
Affinity Capture-MS Homo sapiens
7 BZW1 9689
Affinity Capture-MS Homo sapiens
8 ARF1 375
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KDELR1 is involved
No pathways found

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