Gene description for KDELR1
Gene name KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Gene symbol KDELR1
Other names/aliases ERD2
ERD2.1
HDEL
PM23
Species Homo sapiens
 Database cross references - KDELR1
ExoCarta ExoCarta_10945
Vesiclepedia VP_10945
Entrez Gene 10945
HGNC 6304
MIM 131235
UniProt P24390  
 KDELR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KDELR1
Molecular Function
    KDEL sequence binding GO:0005046 IDA
    protein binding GO:0005515 IPI
    ER retention sequence binding GO:0046923 IBA
Biological Process
    protein retention in ER lumen GO:0006621 IBA
    retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890 IDA
    protein transport GO:0015031 IEA
    T cell differentiation GO:0030217 IEA
    T cell apoptotic process GO:0070231 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    cis-Golgi network GO:0005801 IBA
    transport vesicle GO:0030133 TAS
    COPI-coated vesicle membrane GO:0030663 IDA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS
 Experiment description of studies that identified KDELR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KDELR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UFD1L 7353
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 F2RL1  
Two-hybrid Homo sapiens
4 KDELR3 11015
Cross-Linking-MS (XL-MS) Homo sapiens
5 LIG4 3981
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 UBQLN4 56893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PSMD6 9861
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 NPLOC4 55666
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 APLNR  
Affinity Capture-MS Homo sapiens
11 PARP1 142
Proximity Label-MS Homo sapiens
12 KDELR1 10945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 COIL  
Proximity Label-MS Homo sapiens
14 COPA 100126041
Protein-peptide Bos taurus
15 TAX1BP1 8887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LAMTOR1 55004
Proximity Label-MS Homo sapiens
17 VPS36 51028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 UBE3A 7337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NEK6 10783
Affinity Capture-MS Homo sapiens
20 KCNC3 3748
Affinity Capture-MS Homo sapiens
21 MFSD4  
Affinity Capture-MS Homo sapiens
22 PSMD11 5717
Affinity Capture-MS Homo sapiens
23 FA2H  
Affinity Capture-MS Homo sapiens
24 ACKR2  
Affinity Capture-MS Homo sapiens
25 SEC23B 10483
Protein-peptide Homo sapiens
26 KRT34  
Two-hybrid Homo sapiens
27 OPALIN  
Affinity Capture-MS Homo sapiens
28 P2RY2 5029
Affinity Capture-MS Homo sapiens
29 SLC2A1 6513
Affinity Capture-MS Homo sapiens
30 SURF4 6836
Affinity Capture-MS Homo sapiens
31 PTEN 5728
Negative Genetic Homo sapiens
32 COPG1  
Protein-peptide Bos taurus
33 RABL3 285282
Affinity Capture-MS Homo sapiens
34 PSMD4 5710
Affinity Capture-MS Homo sapiens
35 COX8A  
Proximity Label-MS Homo sapiens
36 TRAFD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CCR9  
Two-hybrid Homo sapiens
38 SPPL2B 56928
Affinity Capture-MS Homo sapiens
39 AGPAT3 56894
Affinity Capture-MS Homo sapiens
40 KDELR2 11014
Cross-Linking-MS (XL-MS) Homo sapiens
41 P2RY8  
Affinity Capture-MS Homo sapiens
42 FFAR1  
Affinity Capture-MS Homo sapiens
43 WBP5  
Affinity Capture-MS Homo sapiens
44 FAM63A 55793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 GPR35  
Two-hybrid Homo sapiens
46 COPB1 1315
FRET Homo sapiens
47 RHBDD1 84236
Affinity Capture-MS Homo sapiens
48 PRKACA 5566
Biochemical Activity Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 PIGN 23556
Affinity Capture-MS Homo sapiens
51 TSPAN8 7103
Affinity Capture-MS Homo sapiens
52 VIPR2  
Affinity Capture-MS Homo sapiens
53 SEC62 7095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RNF115  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 DLG2 1740
Two-hybrid Homo sapiens
56 SLC43A3 29015
Affinity Capture-MS Homo sapiens
57 MCM2 4171
Affinity Capture-MS Homo sapiens
58 RAB7A 7879
Proximity Label-MS Homo sapiens
59 SERINC3 10955
Affinity Capture-MS Homo sapiens
60 ARF1 375
FRET Homo sapiens
61 TTC9C 283237
Affinity Capture-MS Homo sapiens
62 GINM1 116254
Affinity Capture-MS Homo sapiens
63 EDNRA 1909
Affinity Capture-MS Homo sapiens
64 UBL7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ARFGAP1  
Protein-peptide Bos taurus
66 GPR45  
Affinity Capture-MS Homo sapiens
67 VIPR1  
Affinity Capture-MS Homo sapiens
68 PSMD12 5718
Affinity Capture-MS Homo sapiens
69 BZW1 9689
Affinity Capture-MS Homo sapiens
70 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
71 ATXN3 4287
Affinity Capture-MS Homo sapiens
72 SLC1A1 6505
Affinity Capture-MS Homo sapiens
73 UBQLN1 29979
Affinity Capture-MS Homo sapiens
74 ATP2A3 489
Affinity Capture-MS Homo sapiens
75 VDAC2 7417
Affinity Capture-MS Homo sapiens
76 TMEM63A 9725
Affinity Capture-MS Homo sapiens
77 COPB2 281706
Protein-peptide Bos taurus
78 COPB1  
Protein-peptide Bos taurus
79 ARFGAP1 55738
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
80 S1PR4  
Affinity Capture-MS Homo sapiens
81 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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