Gene description for DLG2
Gene name discs, large homolog 2 (Drosophila)
Gene symbol DLG2
Other names/aliases PPP1R58
Species Homo sapiens
 Database cross references - DLG2
ExoCarta ExoCarta_1740
Entrez Gene 1740
HGNC 2901
MIM 603583
UniProt Q15700  
 DLG2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DLG2
Molecular Function
    kinase binding GO:0019900 IDA
    protein binding GO:0005515 IPI
    ionotropic glutamate receptor binding GO:0035255 IBA
    guanylate kinase activity GO:0004385 TAS
Biological Process
    nucleotide phosphorylation GO:0046939 TAS
    receptor clustering GO:0043113 IBA
    synaptic transmission GO:0007268 IBA
    sensory perception of pain GO:0019233 IEA
    nervous system development GO:0007399 IBA
    negative regulation of phosphatase activity GO:0010923 IDA
    receptor localization to synapse GO:0097120 IBA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IBA
Subcellular Localization
    basolateral plasma membrane GO:0016323 IBA
    plasma membrane GO:0005886 TAS
    juxtaparanode region of axon GO:0044224 ISS
    membrane GO:0016020 ISS
    postsynaptic membrane GO:0045211 IBA
    postsynaptic density GO:0014069 IBA
    ionotropic glutamate receptor complex GO:0008328 IBA
    voltage-gated potassium channel complex GO:0008076 ISS
    cell junction GO:0030054 IEA
 Experiment description of studies that identified DLG2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DLG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLGAP1  
Affinity Capture-Western Homo sapiens
2 NLGN1  
Two-hybrid Homo sapiens
3 LIN7A 8825
Invitro Homo sapiens
4 NLGN3  
Two-hybrid Homo sapiens
5 DLG1 1739
Invivo Homo sapiens
6 NLGN2  
Two-hybrid Homo sapiens
7 GRIN2A  
Two-hybrid Homo sapiens
8 DYNLL2 140735
Affinity Capture-Western Homo sapiens
9 ATP2B4 493
Invitro Homo sapiens
Invivo Homo sapiens
10 ERBB4 2066
Two-hybrid Homo sapiens
11 SEMA4C 54910
Two-hybrid Homo sapiens
12 GRIN2B  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
13 KCNJ12 3768
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 GUCY1A2  
Invitro Homo sapiens
15 DYNLL1 8655
Affinity Capture-Western Homo sapiens
16 KCNJ4  
Affinity Capture-Western Homo sapiens
17 ATP2B2 491
Invitro Homo sapiens
Invivo Homo sapiens
18 LRP2 4036
Two-hybrid Homo sapiens
19 NOS1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
20 DLG4  
Affinity Capture-Western Homo sapiens
21 KCNA4  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DLG2 is involved
No pathways found

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