Gene description for RNASE2
Gene name ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Gene symbol RNASE2
Other names/aliases EDN
RAF3
RNS2
Species Homo sapiens
 Database cross references - RNASE2
ExoCarta ExoCarta_6036
Entrez Gene 6036
HGNC 10045
MIM 131410
UniProt P10153  
 RNASE2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
 Gene ontology annotations for RNASE2
Molecular Function
    nucleic acid binding GO:0003676 IEA
    endonuclease activity GO:0004519 IBA
    ribonuclease activity GO:0004540 TAS
    ribonuclease A activity GO:0004522 IEA
Biological Process
    RNA phosphodiester bond hydrolysis GO:0090501 TAS
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IEA
    nucleic acid phosphodiester bond hydrolysis GO:0090305 IBA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    chemotaxis GO:0006935 IDA
    RNA catabolic process GO:0006401 TAS
Subcellular Localization
    lysosome GO:0005764 IEA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified RNASE2 in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for RNASE2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RNASE2 is involved
No pathways found





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