Gene description for MAP1A
Gene name microtubule-associated protein 1A
Gene symbol MAP1A
Other names/aliases MAP1L
MTAP1A
Species Homo sapiens
 Database cross references - MAP1A
ExoCarta ExoCarta_4130
Entrez Gene 4130
HGNC 6835
MIM 600178
UniProt P78559  
 MAP1A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MAP1A
Molecular Function
    structural molecule activity GO:0005198 NAS
    microtubule binding GO:0008017 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of defense response to virus by host GO:0002230 IMP
    microtubule cytoskeleton organization GO:0000226 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    sensory perception of sound GO:0007605 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    microtubule associated complex GO:0005875 TAS
    microtubule GO:0005874 IEA
 Experiment description of studies that identified MAP1A in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MAP1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBB2A 7280
Invitro Homo sapiens
2 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 TUBA4A 7277
Invitro Homo sapiens
Invivo Homo sapiens
4 MAP1LC3A  
Invivo Homo sapiens
Invitro Homo sapiens
5 UPF2  
Two-hybrid Homo sapiens
6 DLG4  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 MAP1B 4131
Invivo Homo sapiens
Invitro Homo sapiens
8 TUBB  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MAP1A is involved
No pathways found





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