Gene description for DLG1
Gene name	discs, large homolog 1 (Drosophila)
Gene symbol	DLG1
Other names/aliases	DLGH1 SAP-97 SAP97 dJ1061C18.1.1 hdlg
Species	Homo sapiens
Database cross references - DLG1
ExoCarta	ExoCarta_1739
Entrez Gene	1739
HGNC	2900
MIM	601014
UniProt	Q12959
DLG1 identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Hepatocellular carcinoma cells	26054723
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Prostate cancer cells	25844599
Thymus	23844026

Gene ontology annotations for DLG1

Molecular Function     guanylate kinase activity GO:0004385 TAS     phosphatase binding GO:0019902 IPI     phosphoprotein phosphatase activity GO:0004721 TAS     ion channel binding GO:0044325 IPI     potassium channel regulator activity GO:0015459 NAS     protein binding GO:0005515 IPI     cytoskeletal protein binding GO:0008092 TAS     mitogen-activated protein kinase kinase binding GO:0031434 IPI     protein complex scaffold GO:0032947 IEA     L27 domain binding GO:0097016 IPI     ionotropic glutamate receptor binding GO:0035255 IBA     protein C-terminus binding GO:0008022 IPI     protein kinase binding GO:0019901 IPI Biological Process     hard palate development GO:0060022 IEA     embryonic skeletal system morphogenesis GO:0048704 IEA     smooth muscle tissue development GO:0048745 IEA     establishment or maintenance of cell polarity GO:0007163 TAS     reproductive structure development GO:0048608 IEA     synaptic transmission GO:0007268 TAS     negative regulation of mitotic cell cycle GO:0045930 IMP     positive regulation of establishment of protein localization to plasma membrane GO:0090004 IDA     negative regulation of T cell proliferation GO:0042130 IEA     dephosphorylation GO:0016311 TAS     cortical actin cytoskeleton organization GO:0030866 IDA     peristalsis GO:0030432 IEA     endothelial cell proliferation GO:0001935 IDA     negative regulation of protein kinase B signaling GO:0051898 IEA     positive regulation of potassium ion transport GO:0043268 IDA     receptor clustering GO:0043113 IBA     amyloid precursor protein metabolic process GO:0042982 IEA     branching involved in ureteric bud morphogenesis GO:0001658 IEA     negative regulation of epithelial cell proliferation GO:0050680 IEA     regulation of membrane potential GO:0042391 IDA     immunological synapse formation GO:0001771 IEA     positive regulation of actin filament polymerization GO:0030838 IEA     positive regulation of cell proliferation GO:0008284 IEA     establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IBA     lens development in camera-type eye GO:0002088 IEA     nervous system development GO:0007399 IBA     regulation of sodium ion transmembrane transport GO:1902305 TAS     viral process GO:0016032 IEA     activation of protein kinase activity GO:0032147 IEA     axon guidance GO:0007411 TAS     receptor localization to synapse GO:0097120 IBA     protein localization to plasma membrane GO:0072659 TAS     mitotic cell cycle checkpoint GO:0007093 NAS     actin filament organization GO:0007015 IDA     T cell cytokine production GO:0002369 IEA     nucleotide phosphorylation GO:0046939 TAS     T cell activation GO:0042110 IEA     regulation of myelination GO:0031641 IEA     bicellular tight junction assembly GO:0070830 IDA     membrane raft organization GO:0031579 IEA     single organismal cell-cell adhesion GO:0016337 IDA Subcellular Localization     extracellular exosome GO:0070062 IDA     immunological synapse GO:0001772 TAS     cell junction GO:0030054 IDA     membrane raft GO:0045121 IEA     postsynaptic membrane GO:0045211 IBA     perinuclear region of cytoplasm GO:0048471 IDA     cytosol GO:0005829 TAS     basolateral plasma membrane GO:0016323 IDA     lateral plasma membrane GO:0016328 IEA     node of Ranvier GO:0033268 IEA     basal lamina GO:0005605 IEA     sarcolemma GO:0042383 IEA     microtubule GO:0005874 IDA     myelin sheath abaxonal region GO:0035748 IEA     endoplasmic reticulum membrane GO:0005789 IEA     neuromuscular junction GO:0031594 IEA     lateral loop GO:0043219 IEA     Golgi apparatus GO:0005794 IDA     intercalated disc GO:0014704 TAS     nucleus GO:0005634 IDA     endoplasmic reticulum GO:0005783 IDA     bicellular tight junction GO:0005923 IDA     MPP7-DLG1-LIN7 complex GO:0097025 IDA     cell-cell junction GO:0005911 IDA     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 TAS     cytoplasmic side of plasma membrane GO:0009898 IDA     ionotropic glutamate receptor complex GO:0008328 IBA     postsynaptic density GO:0014069 IBA     cell projection membrane GO:0031253 IEA