Gene description for Lin7c
Gene name lin-7 homolog C (C. elegans)
Gene symbol Lin7c
Other names/aliases 9130007B12Rik
AI303698
AU019331
AW125731
D2Ertd520e
LIN-7-C
LIN-7C
MALS-3
Veli3
Species Mus musculus
 Database cross references - Lin7c
ExoCarta ExoCarta_22343
Vesiclepedia VP_22343
Entrez Gene 22343
UniProt O88952  
 Lin7c identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lin7c
Molecular Function
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IEA
    cytoskeletal protein binding GO:0008092 ISO
    protein domain specific binding GO:0019904 ISO
    PDZ domain binding GO:0030165 ISO
    protein-macromolecule adaptor activity GO:0030674 IBA
    L27 domain binding GO:0097016 IEA
    L27 domain binding GO:0097016 ISO
Biological Process
    morphogenesis of an epithelial sheet GO:0002011 IEA
    morphogenesis of an epithelial sheet GO:0002011 ISO
    exocytosis GO:0006887 IEA
    neurotransmitter secretion GO:0007269 IBA
    neurotransmitter secretion GO:0007269 IGI
    regulation of synaptic assembly at neuromuscular junction GO:0008582 IBA
    protein transport GO:0015031 IEA
    synaptic vesicle transport GO:0048489 IBA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IBA
    cell-cell junction GO:0005911 ISO
    bicellular tight junction GO:0005923 IEA
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IEA
    transport vesicle membrane GO:0030658 TAS
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    synapse GO:0045202 IDA
    synapse GO:0045202 ISO
    MPP7-DLG1-LIN7 complex GO:0097025 IBA
    MPP7-DLG1-LIN7 complex GO:0097025 IEA
    MPP7-DLG1-LIN7 complex GO:0097025 ISO
    presynapse GO:0098793 IEA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Lin7c in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lin7c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NET1 10276
Protein-peptide Homo sapiens
2 INADL 10207
Affinity Capture-MS Homo sapiens
3 Nrxn1  
Affinity Capture-MS Mus musculus
4 Wwtr1  
Affinity Capture-Western Mus musculus
5 SFPQ 6421
Affinity Capture-MS Homo sapiens
6 Caskin1  
Affinity Capture-MS Mus musculus
7 Ppfia3  
Affinity Capture-MS Mus musculus
8 MPP6 51678
Affinity Capture-MS Homo sapiens
9 Mpp5  
Affinity Capture-MS Mus musculus
10 MPP5 64398
Affinity Capture-MS Homo sapiens
11 Tax1bp3  
Co-fractionation Mus musculus
12 MPP7 143098
Affinity Capture-MS Homo sapiens
13 CASK 8573
Affinity Capture-MS Homo sapiens
14 Ppfia4  
Affinity Capture-MS Mus musculus
15 Kcnma1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
16 AMOTL2 51421
Affinity Capture-MS Homo sapiens
17 NF2 4771
Affinity Capture-MS Homo sapiens
18 Apba1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
19 DLG1 1739
Affinity Capture-MS Homo sapiens
20 Ppfia1  
Affinity Capture-Western Mus musculus
21 Wfs1  
Co-fractionation Mus musculus
22 Dlg1 13383
Affinity Capture-MS Mus musculus
23 DPCD  
Affinity Capture-MS Homo sapiens
24 Cask 12361
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
25 NONO 4841
Affinity Capture-MS Homo sapiens
26 AMOTL1 154810
Affinity Capture-MS Homo sapiens
27 Grin2b  
Affinity Capture-MS Mus musculus
28 YAP1 10413
Affinity Capture-MS Homo sapiens
29 NUP37 79023
Affinity Capture-MS Homo sapiens
30 WWTR1 25937
Affinity Capture-MS Homo sapiens
31 Ppfia2  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
32 Atpif1  
Co-fractionation Mus musculus
33 Nf2  
Co-fractionation Mus musculus
34 Yap1  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
35 GNAI2 2771
Affinity Capture-MS Homo sapiens
36 SNTB2 6645
Affinity Capture-MS Homo sapiens
37 C15orf57  
Affinity Capture-MS Homo sapiens
38 HERC4 26091
Affinity Capture-MS Homo sapiens
39 MPDZ  
Affinity Capture-MS Homo sapiens
40 MGST3 4259
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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