Gene description for MPP7
Gene name membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Gene symbol MPP7
Other names/aliases -
Species Homo sapiens
 Database cross references - MPP7
ExoCarta ExoCarta_143098
Entrez Gene 143098
HGNC 26542
MIM 610973
UniProt Q5T2T1  
 MPP7 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MPP7
Molecular Function
    protein domain specific binding GO:0019904 IPI
    protein heterodimerization activity GO:0046982 IDA
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 TAS
    protein complex scaffold GO:0032947 IDA
Biological Process
    positive regulation of protein complex assembly GO:0031334 TAS
    positive regulation of signal transduction GO:0009967 TAS
    establishment of cell polarity GO:0030010 TAS
    protein localization to adherens junction GO:0071896 IMP
    bicellular tight junction assembly GO:0070830 IDA
Subcellular Localization
    MPP7-DLG1-LIN7 complex GO:0097025 IDA
    cell junction GO:0030054 IDA
    bicellular tight junction GO:0005923 IDA
    mitochondrion GO:0005739 IDA
    adherens junction GO:0005912 IDA
 Experiment description of studies that identified MPP7 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MPP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MPP7 is involved
No pathways found





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