Gene description for CADM4
Gene name cell adhesion molecule 4
Gene symbol CADM4
Other names/aliases IGSF4C
NECL4
Necl-4
TSLL2
synCAM4
Species Homo sapiens
 Database cross references - CADM4
ExoCarta ExoCarta_199731
Entrez Gene 199731
HGNC 30825
MIM 609744
UniProt Q8NFZ8  
 CADM4 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
 Gene ontology annotations for CADM4
Biological Process
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CADM4 in exosomes
1
Experiment ID 258
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CADM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CADM4 is involved
No pathways found





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