Gene description for EPHA2
Gene name EPH receptor A2
Gene symbol EPHA2
Other names/aliases ARCC2
CTPA
CTPP1
CTRCT6
ECK
Species Homo sapiens
 Database cross references - EPHA2
ExoCarta ExoCarta_1969
Vesiclepedia VP_1969
Entrez Gene 1969
HGNC 3386
MIM 176946
UniProt P29317  
 EPHA2 identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 30918259    
Breast cancer cells 30918259    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 19837982    
Colorectal cancer cells 22740476    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
T lymphocytes 34108659    
 Gene ontology annotations for EPHA2
Molecular Function
    virus receptor activity GO:0001618 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    growth factor binding GO:0019838 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    cadherin binding GO:0045296 HDA
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    molecular function activator activity GO:0140677 EXP
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    skeletal system development GO:0001501 IEA
    vasculogenesis GO:0001570 IEA
    osteoblast differentiation GO:0001649 ISS
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 IEA
    chromatin remodeling GO:0006338 IEA
    inflammatory response GO:0006954 IEA
    cell adhesion GO:0007155 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    multicellular organism development GO:0007275 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IDA
    regulation of lamellipodium assembly GO:0010591 IMP
    notochord formation GO:0014028 IEA
    cell migration GO:0016477 IMP
    negative regulation of angiogenesis GO:0016525 IEA
    neural tube development GO:0021915 IEA
    neuron differentiation GO:0030182 IEA
    keratinocyte differentiation GO:0030216 IMP
    osteoclast differentiation GO:0030316 ISS
    positive regulation of cell migration GO:0030335 IDA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    negative regulation of chemokine production GO:0032682 IEA
    mammary gland epithelial cell proliferation GO:0033598 ISS
    regulation of cell adhesion mediated by integrin GO:0033628 IDA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    post-anal tail morphogenesis GO:0036342 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    regulation of blood vessel endothelial cell migration GO:0043535 ISS
    regulation of angiogenesis GO:0045765 ISS
    cAMP metabolic process GO:0046058 IMP
    symbiont entry into host cell GO:0046718 IEA
    bone remodeling GO:0046849 ISS
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IDA
    axial mesoderm formation GO:0048320 IEA
    cell motility GO:0048870 IMP
    defense response to Gram-positive bacterium GO:0050830 IEA
    notochord cell development GO:0060035 IEA
    cell chemotaxis GO:0060326 IMP
    branching involved in mammary gland duct morphogenesis GO:0060444 ISS
    lens fiber cell morphogenesis GO:0070309 ISS
    regulation of ERK1 and ERK2 cascade GO:0070372 IMP
    response to growth factor GO:0070848 IMP
    protein localization to plasma membrane GO:0072659 IMP
    activation of GTPase activity GO:0090630 IMP
    negative regulation of lymphangiogenesis GO:1901491 IEA
    positive regulation of protein localization to plasma membrane GO:1903078 IMP
    positive regulation of bicellular tight junction assembly GO:1903348 IMP
    pericyte cell differentiation GO:1904238 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 HDA
    focal adhesion GO:0005925 IDA
    cell surface GO:0009986 HDA
    cell surface GO:0009986 IDA
    lamellipodium GO:0030027 IDA
    leading edge membrane GO:0031256 IDA
    lamellipodium membrane GO:0031258 IEA
    ruffle membrane GO:0032587 IEA
    receptor complex GO:0043235 IBA
    tight junction GO:0070160 IDA
 Experiment description of studies that identified EPHA2 in sEVs
1
Experiment ID 76
MISEV standards
EM
Biophysical techniques
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
HSP90B1
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 412
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 414
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
8
Experiment ID 426
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 427
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 924
MISEV standards
EM
Biophysical techniques
CD9|SDCBP|CD81|RAB35|LAMP2|FLOT1|TSG101|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 30918259    
Organism Homo sapiens
Experiment description Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Authors "Im EJ, Lee CH, Moon PG, Rangaswamy GG, Lee B, Lee JM, Lee JC, Jee JG, Bae JS, Kwon TK, Kang KW, Jeong MS, Lee JE, Jung HS, Ro HJ, Jun S, Kang W, Seo SY, Cho YE, Song BJ, Baek MC."
Journal name Nat Commun
Publication year 2019
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 927
MISEV standards
EM
Biophysical techniques
CD9|SDCBP|CD81|RAB35|LAMP2|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 30918259    
Organism Homo sapiens
Experiment description Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
Authors "Im EJ, Lee CH, Moon PG, Rangaswamy GG, Lee B, Lee JM, Lee JC, Jee JG, Bae JS, Kwon TK, Kang KW, Jeong MS, Lee JE, Jung HS, Ro HJ, Jun S, Kang W, Seo SY, Cho YE, Song BJ, Baek MC."
Journal name Nat Commun
Publication year 2019
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
15
Experiment ID 201
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22740476    
Organism Homo sapiens
Experiment description Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4.
Authors "Lim JW, Mathias RA, Kapp EA, Layton MJ, Faux MC, Burgess AW, Ji H, Simpson RJ."
Journal name Electrophoresis
Publication year 2012
Sample Colorectal cancer cells
Sample name SW480
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
17
Experiment ID 407
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
21
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
22
Experiment ID 405
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 417
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 411
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 255
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 256
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 258
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1|CD81
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 259
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
32
Experiment ID 260
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1|CD81
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
34
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
35
Experiment ID 418
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 413
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 406
MISEV standards
EM
Biophysical techniques
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 415
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 434
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
42
Experiment ID 435
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 408
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
44
Experiment ID 409
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 416
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
47
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
48
Experiment ID 410
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for EPHA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
2 ROBO1 6091
Proximity Label-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 APPL2 55198
Proximity Label-MS Homo sapiens
5 WDR6 11180
Proximity Label-MS Homo sapiens
6 UTRN 7402
Proximity Label-MS Homo sapiens
7 MACROD1 28992
Affinity Capture-MS Homo sapiens
8 SHC1 6464
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 LLGL1 3996
Proximity Label-MS Homo sapiens
10 DAG1 1605
Proximity Label-MS Homo sapiens
11 STXBP6 29091
Proximity Label-MS Homo sapiens
12 TPTE2  
Two-hybrid Homo sapiens
13 GLB1 2720
Proximity Label-MS Homo sapiens
14 JPH1 56704
Proximity Label-MS Homo sapiens
15 C1orf226  
Proximity Label-MS Homo sapiens
16 MAP4K4 9448
Proximity Label-MS Homo sapiens
17 MID1 4281
Proximity Label-MS Homo sapiens
18 BTN3A3 10384
Proximity Label-MS Homo sapiens
19 AKAP8L  
Proximity Label-MS Homo sapiens
20 ANKRD50 57182
Proximity Label-MS Homo sapiens
21 EFNA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
22 USP6NL 9712
Proximity Label-MS Homo sapiens
23 MPP5 64398
Proximity Label-MS Homo sapiens
24 APBB2  
Proximity Label-MS Homo sapiens
25 GNS 2799
Proximity Label-MS Homo sapiens
26 RD3  
Affinity Capture-MS Homo sapiens
27 PACS1 55690
Proximity Label-MS Homo sapiens
28 TRIOBP 11078
Proximity Label-MS Homo sapiens
29 DUSP14 11072
Two-hybrid Homo sapiens
30 UNC5B 219699
Proximity Label-MS Homo sapiens
31 SRC 6714
Proximity Label-MS Homo sapiens
32 HEXB 3074
Proximity Label-MS Homo sapiens
33 MTMR2 8898
Proximity Label-MS Homo sapiens
34 ABI1 10006
Proximity Label-MS Homo sapiens
35 PTPRR  
Two-hybrid Homo sapiens
36 MAN1A1 4121
Affinity Capture-MS Homo sapiens
37 ZBTB14  
Affinity Capture-MS Homo sapiens
38 WBP2 23558
Proximity Label-MS Homo sapiens
39 SLC6A15 55117
Proximity Label-MS Homo sapiens
40 ZFYVE9  
Proximity Label-MS Homo sapiens
41 SDHA 6389
Proximity Label-MS Homo sapiens
42 EXOC3 11336
Proximity Label-MS Homo sapiens
43 EXOC4 60412
Proximity Label-MS Homo sapiens
44 NOTCH2 4853
Proximity Label-MS Homo sapiens
45 TFB1M  
Proximity Label-MS Homo sapiens
46 HEXIM1 10614
Affinity Capture-MS Homo sapiens
47 NOMO1 23420
Proximity Label-MS Homo sapiens
48 CNNM3 26505
Proximity Label-MS Homo sapiens
49 CTBP1 1487
Proximity Label-MS Homo sapiens
50 MCAM 4162
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
51 EFR3B  
Proximity Label-MS Homo sapiens
52 PDXDC1 23042
Proximity Label-MS Homo sapiens
53 NTRK3 4916
Affinity Capture-MS Homo sapiens
54 CDH1 999
Proximity Label-MS Homo sapiens
55 NEDD4L 23327
Proximity Label-MS Homo sapiens
56 TAMM41  
Proximity Label-MS Homo sapiens
57 SEMA6D  
Proximity Label-MS Homo sapiens
58 MPP7 143098
Proximity Label-MS Homo sapiens
59 FLOT2 2319
Proximity Label-MS Homo sapiens
60 PICALM 8301
Proximity Label-MS Homo sapiens
61 CTDSPL 10217
Proximity Label-MS Homo sapiens
62 CCDC28A  
Proximity Label-MS Homo sapiens
63 LRCH3 84859
Proximity Label-MS Homo sapiens
64 LRP8 7804
Proximity Label-MS Homo sapiens
65 MTSS1L 92154
Proximity Label-MS Homo sapiens
66 ZDHHC20 253832
Proximity Label-MS Homo sapiens
67 SIPA1L2  
Proximity Label-MS Homo sapiens
68 DST 667
Proximity Label-MS Homo sapiens
69 CSNK1G3 1456
Proximity Label-MS Homo sapiens
70 PALM2  
Proximity Label-MS Homo sapiens
71 EPB41L1 2036
Proximity Label-MS Homo sapiens
72 FLVCR1 28982
Proximity Label-MS Homo sapiens
73 ARHGAP32  
Proximity Label-MS Homo sapiens
74 FAM83B  
Proximity Label-MS Homo sapiens
75 FAM129B 64855
Proximity Label-MS Homo sapiens
76 SIGLECL1  
Affinity Capture-MS Homo sapiens
77 SPECC1 92521
Proximity Label-MS Homo sapiens
78 NDUFA13 51079
Affinity Capture-MS Homo sapiens
79 ARRDC4  
Affinity Capture-MS Homo sapiens
80 SCAMP1 9522
Proximity Label-MS Homo sapiens
81 ERBB2IP 55914
Proximity Label-MS Homo sapiens
82 ANXA1 301
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 DLG1 1739
Proximity Label-MS Homo sapiens
84 SRGAP2 23380
Proximity Label-MS Homo sapiens
85 DUSP26 78986
Two-hybrid Homo sapiens
86 ERBB4 2066
Proximity Label-MS Homo sapiens
87 ATP1B3 483
Proximity Label-MS Homo sapiens
88 PIK3C2B 5287
Proximity Label-MS Homo sapiens
89 SBF1 6305
Proximity Label-MS Homo sapiens
90 MAGEB10  
Affinity Capture-MS Homo sapiens
91 ABCC1 4363
Proximity Label-MS Homo sapiens
92 MPZL1 9019
Proximity Label-MS Homo sapiens
93 RAB11FIP2  
Proximity Label-MS Homo sapiens
94 OPCML  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 DZIP1  
Proximity Label-MS Homo sapiens
96 EPB41L4B 54566
Proximity Label-MS Homo sapiens
97 MAP4K3 8491
Proximity Label-MS Homo sapiens
98 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
99 CTNNA1 1495
Proximity Label-MS Homo sapiens
100 KIDINS220 57498
Proximity Label-MS Homo sapiens
101 EFNB2 1948
Proximity Label-MS Homo sapiens
102 GRIP1  
Proximity Label-MS Homo sapiens
103 KRT222 125113
Proximity Label-MS Homo sapiens
104 CDC42EP4  
Proximity Label-MS Homo sapiens
105 MALL  
Affinity Capture-MS Homo sapiens
106 GOLGB1 2804
Proximity Label-MS Homo sapiens
107 DUSP19  
Two-hybrid Homo sapiens
108 DENND6A 201627
Proximity Label-MS Homo sapiens
109 GPRIN3  
Proximity Label-MS Homo sapiens
110 PSD3 23362
Proximity Label-MS Homo sapiens
111 GRB2 2885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 ATP2B4 493
Proximity Label-MS Homo sapiens
113 USP46 64854
Proximity Label-MS Homo sapiens
114 VOPP1  
Affinity Capture-MS Homo sapiens
115 COQ5  
Proximity Label-MS Homo sapiens
116 RAB27B 5874
Proximity Label-MS Homo sapiens
117 WWOX 51741
Proximity Label-MS Homo sapiens
118 MACF1 23499
Proximity Label-MS Homo sapiens
119 CDC37 11140
Affinity Capture-MS Homo sapiens
120 LCK 3932
Proximity Label-MS Homo sapiens
121 RASA3 22821
Proximity Label-MS Homo sapiens
122 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
123 TRIP11 9321
Proximity Label-MS Homo sapiens
124 ANKRD26 22852
Proximity Label-MS Homo sapiens
125 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
126 ITGA2 3673
Proximity Label-MS Homo sapiens
127 EPHA6 285220
Affinity Capture-MS Homo sapiens
128 PHACTR4 65979
Proximity Label-MS Homo sapiens
129 GOLGA5 9950
Proximity Label-MS Homo sapiens
130 MARK1 4139
Proximity Label-MS Homo sapiens
131 DDR1 780
Affinity Capture-MS Homo sapiens
132 RAB11A 8766
Proximity Label-MS Homo sapiens
133 C1orf21  
Proximity Label-MS Homo sapiens
134 PLEKHA7 144100
Proximity Label-MS Homo sapiens
135 ACACB 32
Proximity Label-MS Homo sapiens
136 SHARPIN  
Affinity Capture-MS Homo sapiens
137 RAB5C 5878
Proximity Label-MS Homo sapiens
138 GATAD1  
Two-hybrid Homo sapiens
139 VANGL1 81839
Proximity Label-MS Homo sapiens
140 PARD6A  
Proximity Label-MS Homo sapiens
141 FAM92A1  
Proximity Label-MS Homo sapiens
142 SP7  
Affinity Capture-MS Homo sapiens
143 SCAMP3 10067
Affinity Capture-MS Homo sapiens
144 CTNNAL1 8727
Proximity Label-MS Homo sapiens
145 TTC7B 145567
Proximity Label-MS Homo sapiens
146 CTNND1 1500
Proximity Label-MS Homo sapiens
147 PSME2 5721
Two-hybrid Homo sapiens
148 AFG3L2 10939
Proximity Label-MS Homo sapiens
149 DENND4B  
Proximity Label-MS Homo sapiens
150 ABLIM1 3983
Proximity Label-MS Homo sapiens
151 OSBPL10  
Proximity Label-MS Homo sapiens
152 KPNA3 3839
Two-hybrid Homo sapiens
153 METTL7A 25840
Proximity Label-MS Homo sapiens
154 LAMP3  
Proximity Label-MS Homo sapiens
155 NOS1AP  
Proximity Label-MS Homo sapiens
156 GJA1 2697
Proximity Label-MS Homo sapiens
157 TARDBP 23435
Affinity Capture-MS Homo sapiens
158 AP2A1 160
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
159 HSPA12B 116835
Proximity Label-MS Homo sapiens
160 DTNA  
Proximity Label-MS Homo sapiens
161 PHLDB1 23187
Proximity Label-MS Homo sapiens
162 CNP 1267
Proximity Label-MS Homo sapiens
163 ROCK2 9475
Proximity Label-MS Homo sapiens
164 PLCH1  
Proximity Label-MS Homo sapiens
165 NDUFS2 4720
Proximity Label-MS Homo sapiens
166 CDH2 1000
Proximity Label-MS Homo sapiens
167 TGFBR1 7046
Affinity Capture-MS Homo sapiens
168 VANGL2  
Proximity Label-MS Homo sapiens
169 LRRC1 55227
Proximity Label-MS Homo sapiens
170 TNIK 23043
Proximity Label-MS Homo sapiens
171 MAP4K5 11183
Proximity Label-MS Homo sapiens
172 STEAP3 55240
Proximity Label-MS Homo sapiens
173 PTK7 5754
Proximity Label-MS Homo sapiens
174 TAS2R7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 PTPN14 5784
Proximity Label-MS Homo sapiens
176 ELMO2 63916
Proximity Label-MS Homo sapiens
177 PALM 5064
Proximity Label-MS Homo sapiens
178 GFOD2 81577
Proximity Label-MS Homo sapiens
179 FTSJ1 24140
Proximity Label-MS Homo sapiens
180 EBAG9 9166
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
181 LMAN1 3998
Proximity Label-MS Homo sapiens
182 COBL  
Proximity Label-MS Homo sapiens
183 AGAP1  
Proximity Label-MS Homo sapiens
184 RAB5A 5868
Proximity Label-MS Homo sapiens
185 STAM2 10254
Proximity Label-MS Homo sapiens
186 CYP2S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 MIB1 57534
Proximity Label-MS Homo sapiens
188 CDK5 1020
Proximity Label-MS Homo sapiens
189 RAI14 26064
Proximity Label-MS Homo sapiens
190 NHS 4810
Proximity Label-MS Homo sapiens
191 LYN 4067
Proximity Label-MS Homo sapiens
192 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
193 SNAP47 116841
Proximity Label-MS Homo sapiens
194 ADD2 119
Proximity Label-MS Homo sapiens
195 CDKAL1  
Proximity Label-MS Homo sapiens
196 RELL1 768211
Proximity Label-MS Homo sapiens
197 LAMP1 3916
Proximity Label-MS Homo sapiens
198 RAB2A 5862
Proximity Label-MS Homo sapiens
199 CACNB2  
Proximity Label-MS Homo sapiens
200 STX5 6811
Proximity Label-MS Homo sapiens
201 PHACTR2  
Proximity Label-MS Homo sapiens
202 C11orf49  
Proximity Label-MS Homo sapiens
203 AGPS 8540
Proximity Label-MS Homo sapiens
204 MRAP2  
Affinity Capture-MS Homo sapiens
205 FAM171A1 221061
Proximity Label-MS Homo sapiens
206 RBSN 64145
Proximity Label-MS Homo sapiens
207 NDC1 55706
Proximity Label-MS Homo sapiens
208 DNAJC5B  
Proximity Label-MS Homo sapiens
209 TPX2  
Affinity Capture-MS Homo sapiens
210 MINK1 50488
Proximity Label-MS Homo sapiens
211 PTPN11 5781
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
212 DAB2IP 153090
Proximity Label-MS Homo sapiens
213 SMARCAD1  
Affinity Capture-MS Homo sapiens
214 SLA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
215 MRPS35 60488
Affinity Capture-MS Homo sapiens
216 ILKAP 80895
Two-hybrid Homo sapiens
217 ADCY9 115
Proximity Label-MS Homo sapiens
218 ARVCF 421
Proximity Label-MS Homo sapiens
219 RGP1 9827
Proximity Label-MS Homo sapiens
220 CDC42EP1 11135
Proximity Label-MS Homo sapiens
221 PHLDB3  
Proximity Label-MS Homo sapiens
222 RICTOR 253260
Proximity Label-MS Homo sapiens
223 EGFR 1956
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
224 FARP2 9855
Proximity Label-MS Homo sapiens
225 PACSIN3 29763
Proximity Label-MS Homo sapiens
226 GAB1  
Proximity Label-MS Homo sapiens
227 PLEKHA5 54477
Proximity Label-MS Homo sapiens
228 SMAD2 4087
Proximity Label-MS Homo sapiens
229 PCDH7 5099
Proximity Label-MS Homo sapiens
230 EPHA2 1969
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
231 PTK2 5747
Affinity Capture-Western Homo sapiens
232 PPM1L 151742
Two-hybrid Homo sapiens
233 PKP4 8502
Proximity Label-MS Homo sapiens
234 DAAM1 23002
Proximity Label-MS Homo sapiens
235 SLC12A7 10723
Proximity Label-MS Homo sapiens
236 PEAK1 79834
Proximity Label-MS Homo sapiens
237 SLC12A6 9990
Proximity Label-MS Homo sapiens
238 RHOB 388
Proximity Label-MS Homo sapiens
239 FYTTD1  
Proximity Label-MS Homo sapiens
240 STYX  
Two-hybrid Homo sapiens
241 MPRIP 23164
Proximity Label-MS Homo sapiens
242 LEMD3  
Proximity Label-MS Homo sapiens
243 KIAA0195 9772
Proximity Label-MS Homo sapiens
244 GPRIN1 114787
Proximity Label-MS Homo sapiens
245 OSBPL8 114882
Proximity Label-MS Homo sapiens
246 LRRC16A 55604
Proximity Label-MS Homo sapiens
247 MARK3 4140
Proximity Label-MS Homo sapiens
248 RNF43  
Proximity Label-MS Homo sapiens
249 CIR1  
Affinity Capture-MS Homo sapiens
250 TMEM51 55092
Proximity Label-MS Homo sapiens
251 PLXNB2 23654
Proximity Label-MS Homo sapiens
252 PRKCSH 5589
Proximity Label-MS Homo sapiens
253 ARFIP1 27236
Proximity Label-MS Homo sapiens
254 DLG3 1741
Proximity Label-MS Homo sapiens
255 MVB12B 89853
Proximity Label-MS Homo sapiens
256 GOSR1 9527
Proximity Label-MS Homo sapiens
257 EZR 7430
Proximity Label-MS Homo sapiens
258 RYK 6259
Affinity Capture-MS Homo sapiens
259 UBE4A 9354
Biochemical Activity Homo sapiens
260 EPN2 22905
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
261 MICAL3 57553
Proximity Label-MS Homo sapiens
262 GOLIM4 27333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
263 EPHA3 2042
Proximity Label-MS Homo sapiens
264 ERGIC2 51290
Proximity Label-MS Homo sapiens
265 ABI2 10152
Proximity Label-MS Homo sapiens
266 SLC30A1 7779
Proximity Label-MS Homo sapiens
267 KIAA1217 56243
Proximity Label-MS Homo sapiens
268 ATP1A1 476
Proximity Label-MS Homo sapiens
269 SPTLC1 10558
Proximity Label-MS Homo sapiens
270 IGF2R 3482
Proximity Label-MS Homo sapiens
271 C2CD5 9847
Proximity Label-MS Homo sapiens
272 ATAD3B 83858
Proximity Label-MS Homo sapiens
273 ANK3  
Proximity Label-MS Homo sapiens
274 CKAP4 10970
Proximity Label-MS Homo sapiens
275 VPS33B 26276
Proximity Label-MS Homo sapiens
276 RALGAPA2  
Proximity Label-MS Homo sapiens
277 SLC3A2 6520
Proximity Label-MS Homo sapiens
278 SCFD1 23256
Proximity Label-MS Homo sapiens
279 AP2S1 1175
Affinity Capture-Western Homo sapiens
280 LRRIQ1  
Affinity Capture-MS Homo sapiens
281 ZDHHC5 25921
Proximity Label-MS Homo sapiens
282 Caskin1  
Two-hybrid Rattus norvegicus
283 OCLN 100506658
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
284 MARCKS 4082
Proximity Label-MS Homo sapiens
285 CTPS2 56474
Proximity Label-MS Homo sapiens
286 NAPA 8775
Proximity Label-MS Homo sapiens
287 PARD3 56288
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
288 EPB41L5 57669
Proximity Label-MS Homo sapiens
289 ADGRL2 23266
Proximity Label-MS Homo sapiens
290 EPS15 2060
Affinity Capture-Western Homo sapiens
291 MICALL1 85377
Affinity Capture-MS Homo sapiens
292 ADD3 120
Proximity Label-MS Homo sapiens
293 SHB 6461
Proximity Label-MS Homo sapiens
294 EPS8 2059
Proximity Label-MS Homo sapiens
295 CBY1  
Proximity Label-MS Homo sapiens
296 STX4 6810
Proximity Label-MS Homo sapiens
297 PI4KA 5297
Proximity Label-MS Homo sapiens
298 LRPPRC 10128
Proximity Label-MS Homo sapiens
299 MET 4233
Proximity Label-MS Homo sapiens
300 TPGS1  
Proximity Label-MS Homo sapiens
301 GTF2H2C  
Proximity Label-MS Homo sapiens
302 NDUFB9 4715
Proximity Label-MS Homo sapiens
303 WDR48 57599
Proximity Label-MS Homo sapiens
304 ERICH5  
Proximity Label-MS Homo sapiens
305 MLLT4 4301
Proximity Label-MS Homo sapiens
306 FAM171A2 284069
Proximity Label-MS Homo sapiens
307 MCM2 4171
Proximity Label-MS Homo sapiens
308 RASAL2 9462
Proximity Label-MS Homo sapiens
309 TBC1D24 57465
Proximity Label-MS Homo sapiens
310 RAB3B 5865
Proximity Label-MS Homo sapiens
311 DSC2 1824
Proximity Label-MS Homo sapiens
312 PCDH19 57526
Proximity Label-MS Homo sapiens
313 DMD 1756
Proximity Label-MS Homo sapiens
314 PHLDB2 90102
Proximity Label-MS Homo sapiens
315 EPHA1 2041
Affinity Capture-MS Homo sapiens
316 ITGA4 3676
Proximity Label-MS Homo sapiens
317 EDAR  
Affinity Capture-MS Homo sapiens
318 STXBP3 6814
Proximity Label-MS Homo sapiens
319 CEP89 84902
Proximity Label-MS Homo sapiens
320 SYTL4 94121
Proximity Label-MS Homo sapiens
321 ESYT2 57488
Proximity Label-MS Homo sapiens
322 CCDC88A 55704
Proximity Label-MS Homo sapiens
323 NCSTN 23385
Affinity Capture-MS Homo sapiens
324 MAS1  
Affinity Capture-MS Homo sapiens
325 APPL1 26060
Proximity Label-MS Homo sapiens
326 DSC3 1825
Proximity Label-MS Homo sapiens
327 NUP155 9631
Proximity Label-MS Homo sapiens
328 BSG 682
Proximity Label-MS Homo sapiens
329 NF2 4771
Proximity Label-MS Homo sapiens
330 ITGA3 3675
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
331 IRS4 8471
Proximity Label-MS Homo sapiens
332 EFNA5  
Affinity Capture-MS Homo sapiens
333 USP12 219333
Proximity Label-MS Homo sapiens
334 ITGA6 3655
Proximity Label-MS Homo sapiens
335 IGF1R 3480
Proximity Label-MS Homo sapiens
336 CXADR 1525
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
337 USP8 9101
Proximity Label-MS Homo sapiens
338 RAB4A 5867
Proximity Label-MS Homo sapiens
339 ACACA 31
Proximity Label-MS Homo sapiens
340 DNAJC5 80331
Proximity Label-MS Homo sapiens
341 KRAS 3845
Proximity Label-MS Homo sapiens
342 NUMB 8650
Proximity Label-MS Homo sapiens
343 DIRAS3  
Proximity Label-MS Homo sapiens
344 LRCH1 23143
Proximity Label-MS Homo sapiens
345 NTRK1 4914
Affinity Capture-MS Homo sapiens
346 CCDC8  
Proximity Label-MS Homo sapiens
347 LRBA 987
Proximity Label-MS Homo sapiens
348 PIK3R1 5295
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
349 ARL13B 200894
Proximity Label-MS Homo sapiens
350 CCNY 219771
Proximity Label-MS Homo sapiens
351 SNTB1 6641
Proximity Label-MS Homo sapiens
352 TMEM185A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
353 SLC4A7 9497
Proximity Label-MS Homo sapiens
354 RBL1  
Two-hybrid Homo sapiens
355 ECH1 1891
Proximity Label-MS Homo sapiens
356 EFNA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
357 NUDT9 53343
Two-hybrid Homo sapiens
358 OCRL 4952
Proximity Label-MS Homo sapiens
359 TBC1D22B  
Proximity Label-MS Homo sapiens
360 EEF2 1938
Co-fractionation Homo sapiens
361 TENM3 55714
Proximity Label-MS Homo sapiens
362 VAMP3 9341
Proximity Label-MS Homo sapiens
363 PPP1R37 284352
Proximity Label-MS Homo sapiens
364 STIM1 6786
Proximity Label-MS Homo sapiens
365 ARHGEF16 27237
Affinity Capture-Western Homo sapiens
366 CYFIP2 26999
Proximity Label-MS Homo sapiens
367 BAIAP2L1 55971
Proximity Label-MS Homo sapiens
368 RGS7  
Proximity Label-MS Homo sapiens
369 AP2M1 1173
Affinity Capture-Western Homo sapiens
370 PTPN13 5783
Proximity Label-MS Homo sapiens
371 XPR1 9213
Proximity Label-MS Homo sapiens
372 PLEKHA6 22874
Proximity Label-MS Homo sapiens
373 SEC16A 9919
Proximity Label-MS Homo sapiens
374 RAB9A 9367
Proximity Label-MS Homo sapiens
375 PIK3CA 5290
Proximity Label-MS Homo sapiens
376 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
377 HLA-A 3105
Proximity Label-MS Homo sapiens
378 ATP7A 538
Proximity Label-MS Homo sapiens
379 FLOT1 10211
Proximity Label-MS Homo sapiens
380 WDR37 22884
Proximity Label-MS Homo sapiens
381 PIP5K1A 8394
Proximity Label-MS Homo sapiens
382 DEPDC1B 55789
Proximity Label-MS Homo sapiens
383 LLGL2 3993
Proximity Label-MS Homo sapiens
384 PVRL2 5819
Proximity Label-MS Homo sapiens
385 MAPKAP1 79109
Proximity Label-MS Homo sapiens
386 STX16 8675
Proximity Label-MS Homo sapiens
387 CTDSP1 58190
Proximity Label-MS Homo sapiens
388 JUP 3728
Proximity Label-MS Homo sapiens
389 SEC23IP 11196
Proximity Label-MS Homo sapiens
390 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
391 MARK2 2011
Proximity Label-MS Homo sapiens
392 FAM171B  
Proximity Label-MS Homo sapiens
393 LSR 51599
Proximity Label-MS Homo sapiens
394 EPHA4 2043
Proximity Label-MS Homo sapiens
395 BLZF1  
Proximity Label-MS Homo sapiens
396 EFNA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
397 INSR 3643
Proximity Label-MS Homo sapiens
398 HSPB1 3315
Proximity Label-MS Homo sapiens
399 C3orf14  
Proximity Label-MS Homo sapiens
400 ERGIC1 57222
Proximity Label-MS Homo sapiens
401 C11orf52 91894
Proximity Label-MS Homo sapiens
402 UFL1 23376
Proximity Label-MS Homo sapiens
403 PPP1R9A  
Proximity Label-MS Homo sapiens
404 LSM7  
Two-hybrid Homo sapiens
405 PPP1R13B  
Proximity Label-MS Homo sapiens
406 INF2 64423
Proximity Label-MS Homo sapiens
407 ITGA7 3679
Proximity Label-MS Homo sapiens
408 FRS2 10818
Proximity Label-MS Homo sapiens
409 RAB7A 7879
Proximity Label-MS Homo sapiens
410 ROBO2 6092
Proximity Label-MS Homo sapiens
411 EHBP1 23301
Proximity Label-MS Homo sapiens
412 TPTE  
Two-hybrid Homo sapiens
413 CYFIP1 23191
Proximity Label-MS Homo sapiens
414 ITGB5 3693
Affinity Capture-Western Homo sapiens
415 CCR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
416 CAV1 857
Proximity Label-MS Homo sapiens
417 STAM 8027
Proximity Label-MS Homo sapiens
418 IARS2 55699
Proximity Label-MS Homo sapiens
419 HLA-C 3107
Proximity Label-MS Homo sapiens
420 ADRBK1 156
Two-hybrid Homo sapiens
421 ARHGAP21 57584
Proximity Label-MS Homo sapiens
422 SLC29A1 2030
Proximity Label-MS Homo sapiens
423 PARD3B 117583
Proximity Label-MS Homo sapiens
424 ABL2  
Proximity Label-MS Homo sapiens
425 AP2B1 163
Affinity Capture-Western Homo sapiens
426 ANKLE2 23141
Proximity Label-MS Homo sapiens
427 RFTN1 23180
Proximity Label-MS Homo sapiens
428 SNAP23 8773
Proximity Label-MS Homo sapiens
429 CABLES2  
Proximity Label-MS Homo sapiens
430 AKAP12 9590
Proximity Label-MS Homo sapiens
431 PIFO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
432 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
433 LPHN1  
Proximity Label-MS Homo sapiens
434 PHLPP1  
Proximity Label-MS Homo sapiens
435 TSG101 7251
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
436 SASH1 23328
Proximity Label-MS Homo sapiens
437 LAMP2 3920
Proximity Label-MS Homo sapiens
438 PLEKHA2 59339
Proximity Label-MS Homo sapiens
439 PRR5  
Proximity Label-MS Homo sapiens
440 SLC12A2 6558
Proximity Label-MS Homo sapiens
441 APP 351
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
442 USP31 57478
Proximity Label-MS Homo sapiens
443 PDE2A  
Affinity Capture-MS Homo sapiens
444 FAM126A 84668
Proximity Label-MS Homo sapiens
445 RALGAPB 57148
Proximity Label-MS Homo sapiens
446 B3GAT1  
Proximity Label-MS Homo sapiens
447 SEMA6A  
Proximity Label-MS Homo sapiens
448 TGFB1 7040
Affinity Capture-MS Homo sapiens
449 SLC39A10 57181
Proximity Label-MS Homo sapiens
450 WDR20 91833
Proximity Label-MS Homo sapiens
451 STIM2 57620
Proximity Label-MS Homo sapiens
452 SCRIB 23513
Proximity Label-MS Homo sapiens
453 YES1 7525
Proximity Label-MS Homo sapiens
454 CPD 1362
Proximity Label-MS Homo sapiens
455 HGS 9146
Proximity Label-MS Homo sapiens
456 STX7 8417
Proximity Label-MS Homo sapiens
457 ADD1 118
Proximity Label-MS Homo sapiens
458 UNC5C  
Proximity Label-MS Homo sapiens
459 SEMA4C 54910
Proximity Label-MS Homo sapiens
460 ALK 238
Affinity Capture-MS Homo sapiens
461 FAM135A  
Proximity Label-MS Homo sapiens
462 STX6 10228
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
463 SLC30A5 64924
Proximity Label-MS Homo sapiens
464 GUSB 2990
Proximity Label-MS Homo sapiens
465 ARHGAP5 394
Proximity Label-MS Homo sapiens
466 VAT1 10493
Proximity Label-MS Homo sapiens
467 ATP6V0D1 9114
Proximity Label-MS Homo sapiens
468 RAB35 11021
Proximity Label-MS Homo sapiens
469 CBLB 868
Proximity Label-MS Homo sapiens
470 SSR3 6747
Affinity Capture-MS Homo sapiens
471 ERBB2 2064
PCA Homo sapiens
Proximity Label-MS Homo sapiens
472 TMEM2 23670
Proximity Label-MS Homo sapiens
473 LAMTOR1 55004
Proximity Label-MS Homo sapiens
474 PLCB1 23236
Proximity Label-MS Homo sapiens
475 CASK 8573
Proximity Label-MS Homo sapiens
476 CADM4 199731
Proximity Label-MS Homo sapiens
477 PDK1 5163
Proximity Label-MS Homo sapiens
478 ITGB3 3690
Affinity Capture-Western Homo sapiens
479 ARHGEF10 9639
Proximity Label-MS Homo sapiens
480 CDK16 5127
Proximity Label-MS Homo sapiens
481 PCK2 5106
Proximity Label-MS Homo sapiens
482 NPHP1  
Proximity Label-MS Homo sapiens
483 DLGAP4 22839
Proximity Label-MS Homo sapiens
484 GORAB 92344
Proximity Label-MS Homo sapiens
485 GJB7  
Affinity Capture-MS Homo sapiens
486 PAG1 55824
Proximity Label-MS Homo sapiens
487 GIT1 28964
Affinity Capture-MS Homo sapiens
488 C19orf26 255057
Proximity Label-MS Homo sapiens
489 OPA1 4976
Proximity Label-MS Homo sapiens
490 FERMT2 10979
Proximity Label-MS Homo sapiens
491 GOPC 57120
Proximity Label-MS Homo sapiens
492 MTMR1 8776
Proximity Label-MS Homo sapiens
493 GANAB 23193
Proximity Label-MS Homo sapiens
494 RAB11FIP5 26056
Proximity Label-MS Homo sapiens
495 TBC1D10B 26000
Proximity Label-MS Homo sapiens
496 ITCH 83737
Proximity Label-MS Homo sapiens
497 ELOVL5 60481
Proximity Label-MS Homo sapiens
498 ACBD3 64746
Proximity Label-MS Homo sapiens
499 CDK17 5128
Two-hybrid Homo sapiens
500 SNX1 6642
Proximity Label-MS Homo sapiens
501 STK10 6793
Proximity Label-MS Homo sapiens
502 SEC63 11231
Proximity Label-MS Homo sapiens
503 CACHD1  
Proximity Label-MS Homo sapiens
504 PTPRM 5797
Proximity Label-MS Homo sapiens
505 GOLGA3 2802
Proximity Label-MS Homo sapiens
506 FANCD2  
Affinity Capture-MS Homo sapiens
507 VPS4B 9525
Affinity Capture-MS Homo sapiens
508 SDC1 6382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
509 PANX1 24145
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
510 SLC39A6 25800
Proximity Label-MS Homo sapiens
511 RAB34 83871
Proximity Label-MS Homo sapiens
512 ATP2B1 490
Proximity Label-MS Homo sapiens
513 EEPD1 80820
Proximity Label-MS Homo sapiens
514 STXBP1 6812
Proximity Label-MS Homo sapiens
515 EPB41L4A 64097
Proximity Label-MS Homo sapiens
516 CTNNB1 1499
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
517 ATG12  
Proximity Label-MS Homo sapiens
518 TRIO 7204
Proximity Label-MS Homo sapiens
519 PDIA3 2923
Proximity Label-MS Homo sapiens
520 NHSL1  
Proximity Label-MS Homo sapiens
521 SLC7A5 8140
Proximity Label-MS Homo sapiens
522 ARF6 382
Proximity Label-MS Homo sapiens
523 UACA 55075
Proximity Label-MS Homo sapiens
524 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
525 EPHA7 2045
Affinity Capture-MS Homo sapiens
526 PRKCI 5584
Proximity Label-MS Homo sapiens
527 PTPN7 5778
Two-hybrid Homo sapiens
528 PRKACA 5566
Proximity Label-MS Homo sapiens
529 KIRREL 55243
Proximity Label-MS Homo sapiens
530 FCHO2 115548
Proximity Label-MS Homo sapiens
531 SEC31A 22872
Proximity Label-MS Homo sapiens
532 AKAP5  
Proximity Label-MS Homo sapiens
533 PPFIBP1 8496
Proximity Label-MS Homo sapiens
534 SLC7A11 23657
Affinity Capture-MS Homo sapiens
535 CLTC 1213
Affinity Capture-Western Homo sapiens
536 STX10 8677
Proximity Label-MS Homo sapiens
537 DUSP18  
Two-hybrid Homo sapiens
538 PPFIA1 8500
Proximity Label-MS Homo sapiens
539 DUPD1  
Two-hybrid Homo sapiens
540 RAB27A 5873
Proximity Label-MS Homo sapiens
541 NUBPL 80224
Proximity Label-MS Homo sapiens
542 KIAA1522 57648
Proximity Label-MS Homo sapiens
543 CABLES1  
Proximity Label-MS Homo sapiens
544 ARRB2 409
Proximity Label-MS Homo sapiens
545 ANKFY1 51479
Proximity Label-MS Homo sapiens
546 ACP1 52
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
547 MPP6 51678
Proximity Label-MS Homo sapiens
548 ROCK1 6093
Proximity Label-MS Homo sapiens
549 PARD6G 84552
Proximity Label-MS Homo sapiens
550 INPPL1 3636
Proximity Label-MS Homo sapiens
551 EPHB2 2048
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
552 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
553 NISCH 11188
Proximity Label-MS Homo sapiens
554 EPB41L2 2037
Proximity Label-MS Homo sapiens
555 ROR2 4920
Proximity Label-MS Homo sapiens
556 ITGAV 3685
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
557 ITSN2 50618
Proximity Label-MS Homo sapiens
558 PARD6B 84612
Proximity Label-MS Homo sapiens
559 CELSR2  
Proximity Label-MS Homo sapiens
560 SLC38A1 81539
Proximity Label-MS Homo sapiens
561 SLC6A8 6535
Proximity Label-MS Homo sapiens
562 WDR13 64743
Proximity Label-MS Homo sapiens
563 PIK3R2 5296
Proximity Label-MS Homo sapiens
564 LRRC49  
Proximity Label-MS Homo sapiens
565 HSPA12A 259217
Proximity Label-MS Homo sapiens
566 RAPGEF6 51735
Proximity Label-MS Homo sapiens
567 ESYT1 23344
Proximity Label-MS Homo sapiens
568 DSG2 1829
Proximity Label-MS Homo sapiens
569 PIK3R3 8503
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here