Gene description for MTSS1L
Gene name metastasis suppressor 1-like
Gene symbol MTSS1L
Other names/aliases ABBA-1
Species Homo sapiens
 Database cross references - MTSS1L
ExoCarta ExoCarta_92154
Vesiclepedia VP_92154
Entrez Gene 92154
HGNC 25094
UniProt Q765P7  
 MTSS1L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MTSS1L
Molecular Function
    actin binding GO:0003779 IBA
    actin monomer binding GO:0003785 IEA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IBA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IEA
    small GTPase binding GO:0031267 IPI
Biological Process
    plasma membrane organization GO:0007009 IEA
    cell projection assembly GO:0030031 IBA
    cellular response to platelet-derived growth factor stimulus GO:0036120 IDA
    membrane organization GO:0061024 IBA
    activation of GTPase activity GO:0090630 IDA
    lamellipodium organization GO:0097581 IEA
Subcellular Localization
    cytoplasmic side of plasma membrane GO:0009898 IBA
    actin cytoskeleton GO:0015629 IBA
    lamellipodium GO:0030027 IEA
    cortical actin cytoskeleton GO:0030864 IEA
    ruffle membrane GO:0032587 IDA
 Experiment description of studies that identified MTSS1L in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTSS1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPN11 5781
Affinity Capture-MS Homo sapiens
2 FBXW11  
Affinity Capture-MS Homo sapiens
3 GFER  
Affinity Capture-MS Homo sapiens
4 GCA 25801
Affinity Capture-MS Homo sapiens
5 POTEI 653269
Affinity Capture-MS Homo sapiens
6 PDIA4 9601
Affinity Capture-MS Homo sapiens
7 PFN1 5216
Proximity Label-MS Homo sapiens
8 BCL9L  
Affinity Capture-MS Homo sapiens
9 PICALM 8301
Affinity Capture-MS Homo sapiens
10 MIS18A  
Affinity Capture-MS Homo sapiens
11 SCAF1  
Two-hybrid Homo sapiens
12 AMMECR1  
Affinity Capture-MS Homo sapiens
13 YY1 7528
Affinity Capture-MS Homo sapiens
14 TTK 7272
Affinity Capture-MS Homo sapiens
15 FUS 2521
Affinity Capture-MS Homo sapiens
16 ATF1  
Affinity Capture-MS Homo sapiens
17 MTSS1 9788
Affinity Capture-MS Homo sapiens
18 HOXB9  
Affinity Capture-MS Homo sapiens
19 PSMA5 5686
Affinity Capture-MS Homo sapiens
20 ACOX3 8310
Affinity Capture-MS Homo sapiens
21 CHEK1  
Affinity Capture-MS Homo sapiens
22 RILPL1 353116
Affinity Capture-MS Homo sapiens
23 CRYZL1 9946
Affinity Capture-MS Homo sapiens
24 EPHA2 1969
Proximity Label-MS Homo sapiens
25 P4HB 5034
Affinity Capture-MS Homo sapiens
26 AMMECR1L 83607
Affinity Capture-MS Homo sapiens
27 ACTB 60
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SLBP  
Affinity Capture-MS Homo sapiens
29 TXNDC5 81567
Affinity Capture-MS Homo sapiens
30 CHAMP1  
Affinity Capture-MS Homo sapiens
31 CNN2 1265
Affinity Capture-MS Homo sapiens
32 MARS2 92935
Affinity Capture-MS Homo sapiens
33 HSPA9 3313
Affinity Capture-MS Homo sapiens
34 OTUD7B 56957
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MTSS1L is involved
No pathways found





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