Gene description for CNN2
Gene name calponin 2
Gene symbol CNN2
Other names/aliases -
Species Homo sapiens
 Database cross references - CNN2
ExoCarta ExoCarta_1265
Entrez Gene 1265
HGNC 2156
MIM 602373
UniProt Q99439  
 CNN2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CNN2
Molecular Function
    actin binding GO:0003779 IEA
    calmodulin binding GO:0005516 IEA
Biological Process
    negative regulation of phagocytosis GO:0050765 IEA
    regulation of actin filament-based process GO:0032970 IDA
    hemopoiesis GO:0030097 IEA
    cellular response to mechanical stimulus GO:0071260 IDA
    cytoskeleton organization GO:0007010 TAS
    wound healing GO:0042060 IEA
    negative regulation of cell migration GO:0030336 IEA
    positive regulation of gene expression GO:0010628 IEA
    regulation of cell proliferation GO:0042127 IEA
    actomyosin structure organization GO:0031032 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cell-cell junction GO:0005911 TAS
    stress fiber GO:0001725 IDA
    focal adhesion GO:0005925 IDA
    membrane GO:0016020 IDA
    cytoskeleton GO:0005856 TAS
 Experiment description of studies that identified CNN2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CNN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CNN2 is involved
No pathways found





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