Gene description for MAT2B
Gene name methionine adenosyltransferase II, beta
Gene symbol MAT2B
Other names/aliases MAT-II
MATIIbeta
Nbla02999
SDR23E1
TGR
Species Homo sapiens
 Database cross references - MAT2B
ExoCarta ExoCarta_27430
Entrez Gene 27430
HGNC 6905
MIM 605527
UniProt Q9NZL9  
 MAT2B identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for MAT2B
Molecular Function
    enzyme binding GO:0019899 IPI
    protein binding GO:0005515 IPI
    methionine adenosyltransferase regulator activity GO:0048270 IDA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    methylation GO:0032259 TAS
    regulation of catalytic activity GO:0050790 IEA
    xenobiotic metabolic process GO:0006805 TAS
    S-adenosylmethionine biosynthetic process GO:0006556 IEA
    one-carbon metabolic process GO:0006730 IEA
Subcellular Localization
    methionine adenosyltransferase complex GO:0048269 IDA
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IEA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    intracellular GO:0005622 IC
 Experiment description of studies that identified MAT2B in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAT2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAT2A 4144
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MAT2B is involved
PathwayEvidenceSource
Methylation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here