Gene description for ARHGAP21
Gene name Rho GTPase activating protein 21
Gene symbol ARHGAP21
Other names/aliases ARHGAP10
Species Homo sapiens
 Database cross references - ARHGAP21
ExoCarta ExoCarta_57584
Vesiclepedia VP_57584
Entrez Gene 57584
HGNC 23725
MIM 609870
UniProt Q5T5U3  
 ARHGAP21 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ARHGAP21
Molecular Function
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    Golgi organization GO:0007030 IMP
    signal transduction GO:0007165 IEA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    Golgi localization GO:0051645 IBA
    establishment of Golgi localization GO:0051683 IDA
    maintenance of Golgi location GO:0051684 IMP
    organelle transport along microtubule GO:0072384 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IDA
    cell junction GO:0030054 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified ARHGAP21 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ARHGAP21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PPP1CB 5500
Affinity Capture-MS Homo sapiens
3 PHF6  
Affinity Capture-MS Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 KIAA1107  
Affinity Capture-MS Homo sapiens
6 CALML3 810
Affinity Capture-MS Homo sapiens
7 CAPZA2 830
Affinity Capture-MS Homo sapiens
8 Cdh1 12550
Affinity Capture-MS Mus musculus
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 PPIL4  
Affinity Capture-MS Homo sapiens
11 PARD3 56288
Proximity Label-MS Homo sapiens
12 Calml3  
Affinity Capture-MS Mus musculus
13 APC  
Affinity Capture-MS Homo sapiens
14 DBN1 1627
Affinity Capture-MS Homo sapiens
15 ARF3 377
Proximity Label-MS Homo sapiens
16 MAP4K4 9448
Affinity Capture-MS Homo sapiens
17 CALM1 801
Affinity Capture-MS Homo sapiens
18 Actb 11461
Affinity Capture-MS Mus musculus
19 PPP1R10  
Affinity Capture-MS Homo sapiens
20 PLG 5340
Affinity Capture-MS Homo sapiens
21 SOX2  
Affinity Capture-MS Homo sapiens
22 USP36  
Affinity Capture-MS Homo sapiens
23 SAPCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ATPIF1 93974
Affinity Capture-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 IQGAP1 8826
Affinity Capture-MS Homo sapiens
27 CALM3 808
Affinity Capture-MS Homo sapiens
28 CDK16 5127
Affinity Capture-MS Homo sapiens
29 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 C11orf52 91894
Proximity Label-MS Homo sapiens
31 RHOA 387
FRET Homo sapiens
32 Cenpe  
Affinity Capture-MS Mus musculus
33 HMGA2 8091
Affinity Capture-MS Homo sapiens
34 STX6 10228
Proximity Label-MS Homo sapiens
35 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SFN 2810
Affinity Capture-MS Homo sapiens
37 RAB35 11021
Proximity Label-MS Homo sapiens
38 CSNK1D 1453
Affinity Capture-MS Homo sapiens
39 NCK1 4690
Affinity Capture-MS Homo sapiens
40 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PFN1 5216
Proximity Label-MS Homo sapiens
42 KRT8 3856
Proximity Label-MS Homo sapiens
43 S100A2 6273
Affinity Capture-MS Homo sapiens
44 LANCL1 10314
Affinity Capture-MS Homo sapiens
45 PRPH 5630
Proximity Label-MS Homo sapiens
46 LYN 4067
Proximity Label-MS Homo sapiens
47 MAPRE1 22919
Proximity Label-MS Homo sapiens
48 AHNAK 79026
Affinity Capture-MS Homo sapiens
49 ZNF177  
Two-hybrid Homo sapiens
50 CDH1 999
Proximity Label-MS Homo sapiens
51 CHMP4B 128866
Affinity Capture-MS Homo sapiens
52 SP1  
Reconstituted Complex Homo sapiens
53 DIRAS3  
Proximity Label-MS Homo sapiens
54 HMGN1  
Affinity Capture-MS Homo sapiens
55 CTNNB1 1499
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 DCTN1 1639
Proximity Label-MS Homo sapiens
57 NSRP1  
Affinity Capture-MS Homo sapiens
58 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ACTB 60
Proximity Label-MS Homo sapiens
60 CSNK1E 1454
Affinity Capture-MS Homo sapiens
61 PABPN1 8106
Affinity Capture-MS Homo sapiens
62 FBLN5 10516
Affinity Capture-MS Homo sapiens
63 Coro1c 23790
Affinity Capture-MS Mus musculus
64 NECAP1 25977
Affinity Capture-MS Homo sapiens
65 MYH9 4627
Affinity Capture-MS Homo sapiens
66 CCNT1  
Affinity Capture-MS Homo sapiens
67 YWHAE 7531
Affinity Capture-MS Homo sapiens
68 MAT2A 4144
Affinity Capture-MS Homo sapiens
69 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 LIMA1 51474
Affinity Capture-MS Homo sapiens
71 S100P 6286
Affinity Capture-MS Homo sapiens
72 SLC25A12 8604
Affinity Capture-MS Homo sapiens
73 Myh9 17886
Affinity Capture-MS Mus musculus
74 FLNA 2316
Affinity Capture-MS Homo sapiens
75 XPO1 7514
Affinity Capture-MS Homo sapiens
76 LMNB1 4001
Affinity Capture-MS Homo sapiens
77 BAG2 9532
Affinity Capture-MS Homo sapiens
78 ECT2 1894
Affinity Capture-MS Homo sapiens
79 LAMP1 3916
Proximity Label-MS Homo sapiens
80 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 MYO19  
Affinity Capture-MS Homo sapiens
82 PNMA2  
Affinity Capture-MS Homo sapiens
83 MYO5C 55930
Affinity Capture-MS Homo sapiens
84 MYO1C 4641
Affinity Capture-MS Homo sapiens
85 MAPRE3  
Proximity Label-MS Homo sapiens
86 DDX42 11325
Affinity Capture-MS Homo sapiens
87 SYNPO 11346
Affinity Capture-MS Homo sapiens
88 Flnb 286940
Affinity Capture-MS Mus musculus
89 PSPC1 55269
Affinity Capture-MS Homo sapiens
90 NIN 51199
Proximity Label-MS Homo sapiens
91 PKP4 8502
Affinity Capture-MS Homo sapiens
92 S100B 6285
Affinity Capture-MS Homo sapiens
93 FIP1L1 81608
Affinity Capture-MS Homo sapiens
94 RHOB 388
Proximity Label-MS Homo sapiens
95 KRAS 3845
Proximity Label-MS Homo sapiens
96 CTNNA1 1495
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 MSN 4478
Affinity Capture-MS Homo sapiens
98 FLOT1 10211
Proximity Label-MS Homo sapiens
99 RNF43  
Proximity Label-MS Homo sapiens
100 ARRB2 409
Affinity Capture-MS Homo sapiens
101 ANKFY1 51479
Proximity Label-MS Homo sapiens
102 Tmod3 50875
Affinity Capture-MS Mus musculus
103 ANXA2 302
Affinity Capture-MS Homo sapiens
104 PDIA4 9601
Affinity Capture-MS Homo sapiens
105 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
106 EZR 7430
Proximity Label-MS Homo sapiens
107 Myo1c 17913
Affinity Capture-MS Mus musculus
108 LCK 3932
Proximity Label-MS Homo sapiens
109 NINL  
Proximity Label-MS Homo sapiens
110 PRR36 80164
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 MAT2B 27430
Affinity Capture-MS Homo sapiens
112 S100A9 6280
Affinity Capture-MS Homo sapiens
113 AXIN1  
Affinity Capture-MS Homo sapiens
114 Myh10 77579
Affinity Capture-MS Mus musculus
115 RAB2A 5862
Proximity Label-MS Homo sapiens
116 EEF1D 1936
Reconstituted Complex Homo sapiens
117 CEP135  
Proximity Label-MS Homo sapiens
118 MYO1E 4643
Affinity Capture-MS Homo sapiens
119 EPHA2 1969
Proximity Label-MS Homo sapiens
120 ANK3  
Proximity Label-MS Homo sapiens
121 MLLT4 4301
Proximity Label-MS Homo sapiens
122 CKAP4 10970
Affinity Capture-MS Homo sapiens
123 PTRF 284119
Affinity Capture-MS Homo sapiens
124 CAV1 857
Proximity Label-MS Homo sapiens
125 MYO18A 399687
Affinity Capture-MS Homo sapiens
126 CTNND1 1500
Affinity Capture-MS Homo sapiens
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