Gene description for CSNK1E
Gene name casein kinase 1, epsilon
Gene symbol CSNK1E
Other names/aliases CKIepsilon
HCKIE
Species Homo sapiens
 Database cross references - CSNK1E
ExoCarta ExoCarta_1454
Vesiclepedia VP_1454
Entrez Gene 1454
HGNC 2453
MIM 600863
UniProt P49674  
 CSNK1E identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CSNK1E
Molecular Function
    RNA binding GO:0003723 HDA
    protein kinase activity GO:0004672 IDA
    protein kinase activity GO:0004672 ISS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    DNA repair GO:0006281 TAS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 ISS
    endocytosis GO:0006897 IBA
    signal transduction GO:0007165 IBA
    protein localization GO:0008104 IEA
    negative regulation of Wnt signaling pathway GO:0030178 IEA
    negative regulation of protein binding GO:0032091 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    regulation of protein localization GO:0032880 IDA
    circadian regulation of gene expression GO:0032922 ISS
    regulation of circadian rhythm GO:0042752 ISS
    circadian behavior GO:0048512 IEA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 IGI
    canonical Wnt signaling pathway GO:0060070 IMP
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    positive regulation of amyloid-beta formation GO:1902004 IEA
    cellular response to nerve growth factor stimulus GO:1990090 IEA
    positive regulation of non-canonical Wnt signaling pathway GO:2000052 IC
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    growth cone GO:0030426 IEA
    neuronal cell body GO:0043025 IEA
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified CSNK1E in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CSNK1E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Csnk1d  
Affinity Capture-MS Mus musculus
2 RNF149 284996
Affinity Capture-MS Homo sapiens
3 INSIG1  
Affinity Capture-MS Homo sapiens
4 RYK 6259
Affinity Capture-MS Homo sapiens
5 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 SLIT2 9353
Affinity Capture-MS Homo sapiens
8 TMEM208  
Affinity Capture-MS Homo sapiens
9 Edc4  
Affinity Capture-MS Mus musculus
10 TRIM3 10612
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
11 PER1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PHF6  
Affinity Capture-MS Homo sapiens
13 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 OCLN 100506658
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
15 SEC16A 9919
Affinity Capture-MS Homo sapiens
16 AES 166
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
17 SQSTM1 8878
Proximity Label-MS Homo sapiens
18 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
19 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 APC  
Co-localization Homo sapiens
21 FAM110C  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 DEC1  
Two-hybrid Homo sapiens
23 PPP1CC 5501
Two-hybrid Homo sapiens
24 RBX1 9978
Two-hybrid Homo sapiens
25 BYSL 705
Co-fractionation Homo sapiens
26 USP9X 8239
Affinity Capture-MS Homo sapiens
27 PRPF3  
Affinity Capture-MS Homo sapiens
28 DVL3 1857
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 PPP1R10  
Affinity Capture-MS Homo sapiens
30 FAXC  
Affinity Capture-MS Homo sapiens
31 CCDC61  
Affinity Capture-MS Homo sapiens
32 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
33 ZNF618  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HMMR  
Affinity Capture-MS Homo sapiens
35 LRPAP1 4043
Affinity Capture-MS Homo sapiens
36 TCEB3 6924
Affinity Capture-MS Homo sapiens
37 MIER1  
Affinity Capture-MS Homo sapiens
38 TEX264 51368
Affinity Capture-MS Homo sapiens
39 BBS10  
Two-hybrid Homo sapiens
40 ATPIF1 93974
Affinity Capture-MS Homo sapiens
41 PPP2R5D 5528
Two-hybrid Homo sapiens
42 USP39 10713
Co-fractionation Homo sapiens
43 RASAL2 9462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FAM83D 81610
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
45 ANKRD49  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ANKRD6  
Affinity Capture-Western Homo sapiens
47 CPSF7 79869
Affinity Capture-MS Homo sapiens
48 RPS4Y2 140032
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 NCOA3  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
50 DDX58 23586
Affinity Capture-RNA Homo sapiens
51 TIAM1  
Affinity Capture-MS Homo sapiens
52 ZSWIM8 23053
Affinity Capture-MS Homo sapiens
53 FAM207A  
Affinity Capture-MS Homo sapiens
54 C2orf44  
Two-hybrid Homo sapiens
55 TULP3 7289
Affinity Capture-MS Homo sapiens
56 PDIA6 10130
Affinity Capture-MS Homo sapiens
57 NUSAP1 51203
Affinity Capture-MS Homo sapiens
58 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PCM1 5108
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 GTSE1 51512
Affinity Capture-MS Homo sapiens
61 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 MAVS 57506
Affinity Capture-Western Homo sapiens
63 PPP6R3 55291
Affinity Capture-MS Homo sapiens
64 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 MRPL4 51073
Affinity Capture-MS Homo sapiens
66 FOXP2 93986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 WDR5 11091
Affinity Capture-MS Homo sapiens
68 CSNK2B 1460
Two-hybrid Homo sapiens
69 TNFRSF1B  
Affinity Capture-MS Homo sapiens
70 SGOL2 151246
Affinity Capture-MS Homo sapiens
71 SSMEM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 KCNA4  
Affinity Capture-MS Homo sapiens
73 DVL2 1856
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
74 AHCYL1 10768
Affinity Capture-MS Homo sapiens
75 KIF14 9928
Affinity Capture-MS Homo sapiens
76 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 LTBR 4055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 NUP155 9631
Proximity Label-MS Homo sapiens
79 UNC45A 55898
Affinity Capture-MS Homo sapiens
80 TAZ  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
81 CADM4 199731
Two-hybrid Homo sapiens
82 CLOCK  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
83 PPP1CA 5499
Biochemical Activity Homo sapiens
84 NSUN2 54888
Co-fractionation Homo sapiens
85 ARHGAP12  
Affinity Capture-MS Homo sapiens
86 DRICH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 BHLHE41  
Two-hybrid Homo sapiens
88 RORC 6097
Two-hybrid Homo sapiens
89 MCC 4163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PPP1R14A 94274
Reconstituted Complex Homo sapiens
91 CRY1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 CA2 760
Affinity Capture-MS Homo sapiens
93 TAOK1 57551
Two-hybrid Homo sapiens
94 KAT7  
Two-hybrid Homo sapiens
95 FAM110A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
96 PSME1 5720
Affinity Capture-MS Homo sapiens
97 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 PPIL4  
Affinity Capture-MS Homo sapiens
99 MICU2 221154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ARHGEF1 9138
Two-hybrid Homo sapiens
101 PNO1 56902
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
102 FOPNL  
Affinity Capture-MS Homo sapiens
103 FAM107A  
Affinity Capture-MS Homo sapiens
104 CEP72  
Affinity Capture-MS Homo sapiens
105 SMARCA4 6597
Affinity Capture-Western Homo sapiens
106 FBLN7  
Affinity Capture-MS Homo sapiens
107 FARP2 9855
Affinity Capture-MS Homo sapiens
108 RPA2 6118
Proximity Label-MS Homo sapiens
109 TRIM21 6737
Affinity Capture-MS Homo sapiens
110 NTRK1 4914
Affinity Capture-MS Homo sapiens
111 RORA  
Two-hybrid Homo sapiens
112 ARHGAP11A  
Affinity Capture-MS Homo sapiens
113 SPRR2E  
Affinity Capture-MS Homo sapiens
114 Trp53  
Biochemical Activity Mus musculus
115 PTPRD 5789
Reconstituted Complex Homo sapiens
116 BICD2 23299
Proximity Label-MS Homo sapiens
117 TRIM11  
Affinity Capture-MS Homo sapiens
118 NOB1  
Co-fractionation Homo sapiens
119 CSNK1E 1454
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
120 HECTD1 25831
Affinity Capture-MS Homo sapiens
121 FAM110B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 SPANXN2  
Affinity Capture-MS Homo sapiens
123 LYAR 55646
Affinity Capture-MS Homo sapiens
124 CUL2 8453
Affinity Capture-MS Homo sapiens
125 YAP1 10413
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
126 REST 5978
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 SNX22  
Affinity Capture-MS Homo sapiens
128 CACNG4  
Affinity Capture-MS Homo sapiens
129 PIPSL 266971
Affinity Capture-MS Homo sapiens
130 RMDN3 55177
Proximity Label-MS Homo sapiens
131 Cry1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
132 PPM1B 5495
Co-fractionation Homo sapiens
133 UBE2S  
Affinity Capture-MS Homo sapiens
134 STK3 6788
Affinity Capture-MS Homo sapiens
135 ATG4B 23192
Affinity Capture-MS Homo sapiens
136 PER2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 VIPR2  
Affinity Capture-MS Homo sapiens
138 FAM83B  
Affinity Capture-MS Homo sapiens
139 GAPVD1 26130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 PRDX4 10549
Affinity Capture-MS Homo sapiens
141 CAMKK1  
Affinity Capture-MS Homo sapiens
142 TP53BP1 7158
Affinity Capture-MS Homo sapiens
143 XPO1 7514
Affinity Capture-MS Homo sapiens
144 SMARCD1 6602
Affinity Capture-MS Homo sapiens
145 FAM83A  
Affinity Capture-MS Homo sapiens
146 SEC13 6396
Affinity Capture-MS Homo sapiens
147 UBXN7 26043
Affinity Capture-MS Homo sapiens
148 SCG5  
Affinity Capture-MS Homo sapiens
149 EIF1AD 84285
Affinity Capture-MS Homo sapiens
150 GTF3C1  
Two-hybrid Homo sapiens
151 PRKAR2A 5576
Affinity Capture-MS Homo sapiens
152 DBNDD2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
153 CD6 923
Affinity Capture-MS Homo sapiens
154 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 CUL3 8452
Affinity Capture-MS Homo sapiens
156 CTTN 2017
Affinity Capture-MS Homo sapiens
157 CCNT1  
Affinity Capture-MS Homo sapiens
158 FKBP8 23770
Proximity Label-MS Homo sapiens
159 RAB39B 116442
Affinity Capture-MS Homo sapiens
160 PLD5  
Affinity Capture-MS Homo sapiens
161 TMEM74  
Affinity Capture-MS Homo sapiens
162 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
163 Cep152  
Affinity Capture-MS Mus musculus
164 LPIN1 23175
Affinity Capture-Western Homo sapiens
165 NXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 Csnk1e  
Affinity Capture-MS Mus musculus
167 PRKACA 5566
Proximity Label-MS Homo sapiens
168 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
169 Cep72  
Affinity Capture-MS Mus musculus
170 PER3  
Affinity Capture-Western Homo sapiens
171 TACO1  
Affinity Capture-MS Homo sapiens
172 MYC  
Dosage Lethality Homo sapiens
173 Uso1 56041
Affinity Capture-MS Mus musculus
174 DBNDD1  
Affinity Capture-MS Homo sapiens
175 SAV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 NLRP1  
Co-fractionation Homo sapiens
177 OFD1 8481
Affinity Capture-MS Homo sapiens
178 TNS2 23371
Two-hybrid Homo sapiens
179 NDC80 10403
Proximity Label-MS Homo sapiens
180 MYCN  
Affinity Capture-MS Homo sapiens
Synthetic Growth Defect Homo sapiens
181 TCEB2 6923
Affinity Capture-MS Homo sapiens
182 BICD1 636
Proximity Label-MS Homo sapiens
183 CRY2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 Kctd5  
Affinity Capture-MS Mus musculus
186 CLTC 1213
Affinity Capture-MS Homo sapiens
187 UBE2D2 7322
Affinity Capture-MS Homo sapiens
188 C7orf60 154743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 BLOC1S5 63915
Affinity Capture-MS Homo sapiens
190 FKBPL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 RIPK4  
Affinity Capture-MS Homo sapiens
192 BAIAP2 10458
Affinity Capture-MS Homo sapiens
193 BACH2 60468
Affinity Capture-MS Homo sapiens
194 ZNF227  
Two-hybrid Homo sapiens
195 ARNTL  
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
196 FTL 2512
Affinity Capture-MS Homo sapiens
197 RNF43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
198 NUDT21 11051
Affinity Capture-MS Homo sapiens
199 SPICE1  
Affinity Capture-MS Homo sapiens
200 KIF2A 3796
Affinity Capture-MS Homo sapiens
201 DVL1 1855
Affinity Capture-Western Homo sapiens
202 FBXW11  
Two-hybrid Homo sapiens
203 PPP2R5E 5529
Two-hybrid Homo sapiens
204 FBP1 2203