Gene description for CSNK1E
Gene name casein kinase 1, epsilon
Gene symbol CSNK1E
Other names/aliases CKIepsilon
HCKIE
Species Homo sapiens
 Database cross references - CSNK1E
ExoCarta ExoCarta_1454
Vesiclepedia VP_1454
Entrez Gene 1454
HGNC 2453
MIM 600863
UniProt P49674  
 CSNK1E identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CSNK1E
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    protein kinase activity GO:0004672 ISS
Biological Process
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    endocytosis GO:0006897 IBA
    regulation of cell shape GO:0008360 IBA
    protein phosphorylation GO:0006468 ISS
    peptidyl-serine phosphorylation GO:0018105 IBA
    cellular protein localization GO:0034613 IEA
    circadian rhythm GO:0007623 TAS
    DNA repair GO:0006281 TAS
    mitotic cell cycle GO:0000278 TAS
    signal transduction GO:0007165 TAS
    regulation of circadian rhythm GO:0042752 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    Wnt signaling pathway GO:0016055 IBA
    negative regulation of Wnt signaling pathway GO:0030178 IEA
    circadian regulation of gene expression GO:0032922 ISS
    organelle organization GO:0006996 TAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 ISS
    ribonucleoprotein complex GO:0030529 IEA
 Experiment description of studies that identified CSNK1E in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CSNK1E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARNTL  
Biochemical Activity Homo sapiens
2 MCC 4163
Affinity Capture-MS Homo sapiens
3 PER3  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 AKAP9 10142
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 Cry1  
Affinity Capture-Western Mus musculus
6 TP53  
Biochemical Activity Mus musculus
7 DVL1 1855
Invivo Homo sapiens
Invitro Homo sapiens
8 PER1  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 CRY1  
Affinity Capture-MS Homo sapiens
11 DVL2 1856
Two-hybrid Homo sapiens
12 RAD54B  
Two-hybrid Homo sapiens
13 ANKRD6  
Invivo Homo sapiens
Two-hybrid Homo sapiens
14 AXIN1  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here