Gene description for C7orf60
Gene name chromosome 7 open reading frame 60
Gene symbol C7orf60
Other names/aliases -
Species Homo sapiens
 Database cross references - C7orf60
ExoCarta ExoCarta_154743
Vesiclepedia VP_154743
Entrez Gene 154743
HGNC 26475
UniProt Q1RMZ1  
 C7orf60 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for C7orf60
Molecular Function
    methyltransferase activity GO:0008168 IEA
    protein-containing complex binding GO:0044877 IDA
    S-adenosyl-L-methionine binding GO:1904047 IDA
Biological Process
    methylation GO:0032259 IEA
    cellular response to amino acid starvation GO:0034198 IDA
    cellular response to methionine GO:0061431 IDA
    regulation of TORC1 signaling GO:1903432 IDA
    negative regulation of TORC1 signaling GO:1904262 IBA
    positive regulation of TORC1 signaling GO:1904263 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified C7orf60 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for C7orf60
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKAA1 5562
Affinity Capture-MS Homo sapiens
2 KPTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NPRL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 MIF4GD 57409
Affinity Capture-MS Homo sapiens
7 TGFBRAP1 9392
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ITFG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TSR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NPRL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 DEPDC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SHMT1 6470
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 POLR2A 5430
Affinity Capture-MS Homo sapiens
15 TMOD1  
Affinity Capture-MS Homo sapiens
16 SZT2 23334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 C12orf66  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MGEA5 10724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 REN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 VPS11 55823
Affinity Capture-MS Homo sapiens
22 CAMK1 8536
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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