Gene description for CAMK1
Gene name calcium/calmodulin-dependent protein kinase I
Gene symbol CAMK1
Other names/aliases CAMKI
Species Homo sapiens
 Database cross references - CAMK1
ExoCarta ExoCarta_8536
Vesiclepedia VP_8536
Entrez Gene 8536
HGNC 1459
MIM 604998
UniProt Q14012  
 CAMK1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CAMK1
Molecular Function
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 ISS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    ATP binding GO:0005524 IEA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    protein phosphorylation GO:0006468 IDA
    nucleocytoplasmic transport GO:0006913 IEA
    signal transduction GO:0007165 IBA
    nervous system development GO:0007399 IEA
    positive regulation of neuron projection development GO:0010976 IDA
    cell differentiation GO:0030154 IEA
    negative regulation of protein binding GO:0032091 IDA
    regulation of protein localization GO:0032880 IBA
    regulation of protein localization GO:0032880 IDA
    intracellular signal transduction GO:0035556 IMP
    regulation of protein binding GO:0043393 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of protein export from nucleus GO:0046827 IDA
    regulation of synapse organization GO:0050807 IBA
    regulation of muscle cell differentiation GO:0051147 IDA
    positive regulation of muscle cell differentiation GO:0051149 IMP
    positive regulation of synapse structural plasticity GO:0051835 IMP
    positive regulation of syncytium formation by plasma membrane fusion GO:0060143 IMP
    positive regulation of dendritic spine development GO:0060999 IMP
    positive regulation of protein serine/threonine kinase activity GO:0071902 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    postsynaptic density GO:0014069 IBA
 Experiment description of studies that identified CAMK1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CAMK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 GCM1  
Biochemical Activity Homo sapiens
3 CALML3 810
Affinity Capture-MS Homo sapiens
4 ATXN1 6310
Two-hybrid Homo sapiens
5 FAM153C  
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-Western Homo sapiens
7 FAM153B  
Affinity Capture-MS Homo sapiens
8 P2RY10  
Affinity Capture-MS Homo sapiens
9 PRKY  
Affinity Capture-MS Homo sapiens
10 PTH1R  
Affinity Capture-MS Homo sapiens
11 SMCHD1 23347
Affinity Capture-MS Homo sapiens
12 CGB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 GPR17 2840
Affinity Capture-MS Homo sapiens
14 BTNL9  
Affinity Capture-MS Homo sapiens
15 FPR1  
Affinity Capture-MS Homo sapiens
16 Mad2l1bp  
Affinity Capture-MS Mus musculus
17 GYPA  
Affinity Capture-MS Homo sapiens
18 CAMK1D 57118
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NUMA1 4926
Affinity Capture-MS Homo sapiens
20 HDAC9  
Affinity Capture-Western Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CDO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 GCGR  
Affinity Capture-MS Homo sapiens
26 C19orf38  
Affinity Capture-MS Homo sapiens
27 MAP10  
Affinity Capture-MS Homo sapiens
28 PHF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LOC254896  
Affinity Capture-MS Homo sapiens
30 IL16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
31 CCDC106  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 COMTD1 118881
Affinity Capture-MS Homo sapiens
33 HTR2C  
Affinity Capture-MS Homo sapiens
34 SRSF2 6427
Affinity Capture-MS Homo sapiens
35 ST6GALNAC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 APP 351
Reconstituted Complex Homo sapiens
38 CER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 BLK 640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CALM2 805
Affinity Capture-MS Homo sapiens
42 MARK2 2011
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
43 CDK14 5218
Affinity Capture-MS Homo sapiens
44 KITLG  
Affinity Capture-MS Homo sapiens
45 METTL21B  
Affinity Capture-MS Homo sapiens
46 PLA2G2D  
Affinity Capture-MS Homo sapiens
47 PPP2CA 5515
Biochemical Activity Homo sapiens
48 APBA1  
Affinity Capture-MS Homo sapiens
49 HSPB1 3315
Two-hybrid Homo sapiens
50 C7orf60 154743
Affinity Capture-MS Homo sapiens
51 HDAC5 10014
Affinity Capture-Western Homo sapiens
52 CAMKK2 10645
Biochemical Activity Homo sapiens
53 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PPME1 51400
Biochemical Activity Homo sapiens
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