Gene description for HDAC5
Gene name histone deacetylase 5
Gene symbol HDAC5
Other names/aliases HD5
NY-CO-9
Species Homo sapiens
 Database cross references - HDAC5
ExoCarta ExoCarta_10014
Vesiclepedia VP_10014
Entrez Gene 10014
HGNC 14068
MIM 605315
UniProt Q9UQL6  
 HDAC5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for HDAC5
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    transcription corepressor binding GO:0001222 IPI
    chromatin binding GO:0003682 IEA
    histone deacetylase activity GO:0004407 IBA
    histone deacetylase activity GO:0004407 IDA
    protein kinase C binding GO:0005080 IPI
    protein binding GO:0005515 IPI
    histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA
    histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA
    protein lysine deacetylase activity GO:0033558 IMP
    histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA
    identical protein binding GO:0042802 IPI
    histone deacetylase binding GO:0042826 IPI
    metal ion binding GO:0046872 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
    histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA
    histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA
    histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA
    histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    inflammatory response GO:0006954 TAS
    response to xenobiotic stimulus GO:0009410 IEA
    regulation of myotube differentiation GO:0010830 ISS
    negative regulation of myotube differentiation GO:0010832 IMP
    response to activity GO:0014823 IEA
    neuron differentiation GO:0030182 IEA
    B cell differentiation GO:0030183 TAS
    cellular response to insulin stimulus GO:0032869 NAS
    epigenetic regulation of gene expression GO:0040029 IBA
    B cell activation GO:0042113 TAS
    response to cocaine GO:0042220 IEA
    regulation of protein binding GO:0043393 IMP
    negative regulation of gene expression, epigenetic GO:0045814 NAS
    negative regulation of DNA-templated transcription GO:0045892 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    cellular response to lipopolysaccharide GO:0071222 IEA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IMP
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    histone deacetylase complex GO:0000118 TAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified HDAC5 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for HDAC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NPEPPS 9520
Affinity Capture-MS Homo sapiens
2 HDAC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 EIF3C 8663
Affinity Capture-MS Homo sapiens
4 PKM 5315
Affinity Capture-MS Homo sapiens
5 NFATC1 4772
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
6 DDX17 10521
Affinity Capture-MS Homo sapiens
7 UBA1 7317
Affinity Capture-MS Homo sapiens
8 SLC25A1 6576
Affinity Capture-MS Homo sapiens
9 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
10 GCN1L1 10985
Affinity Capture-MS Homo sapiens
11 PRKDC 5591
Affinity Capture-MS Homo sapiens
12 CKB 1152
Affinity Capture-MS Homo sapiens
13 LMO2  
Two-hybrid Homo sapiens
14 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
15 DARS 1615
Affinity Capture-MS Homo sapiens
16 ZBTB21  
Affinity Capture-MS Homo sapiens
17 SF3B1 23451
Affinity Capture-MS Homo sapiens
18 BRMS1 25855
Affinity Capture-Western Homo sapiens
19 ETFA 2108
Affinity Capture-MS Homo sapiens
20 WDR5 11091
Affinity Capture-MS Homo sapiens
21 RPS11 6205
Affinity Capture-MS Homo sapiens
22 TFRC 7037
Affinity Capture-MS Homo sapiens
23 MTA2 9219
Affinity Capture-MS Homo sapiens
24 SLC25A3 5250
Affinity Capture-MS Homo sapiens
25 RBMX 27316
Affinity Capture-MS Homo sapiens
26 TCP1 6950
Affinity Capture-MS Homo sapiens
27 PGAM5 192111
Affinity Capture-MS Homo sapiens
28 CTBP1 1487
Reconstituted Complex Homo sapiens
29 TUFM 7284
Affinity Capture-MS Homo sapiens
30 COPB1 1315
Affinity Capture-MS Homo sapiens
31 HDAC7  
Reconstituted Complex Homo sapiens
32 PABPC1 26986
Affinity Capture-MS Homo sapiens
33 PSMD2 5708
Affinity Capture-MS Homo sapiens
34 MYH9 4627
Affinity Capture-MS Homo sapiens
35 GABARAP 11337
Two-hybrid Homo sapiens
36 ACTN4 81
Affinity Capture-MS Homo sapiens
37 OGT 8473
Affinity Capture-MS Homo sapiens
38 XPOT 11260
Affinity Capture-MS Homo sapiens
39 YWHAQ 10971
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 DDX39B 7919
Affinity Capture-MS Homo sapiens
41 VDAC2 7417
Affinity Capture-MS Homo sapiens
42 CKMT1B 1159
Affinity Capture-MS Homo sapiens
43 GATA3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 HSPA5 3309
Affinity Capture-MS Homo sapiens
45 RBM39 9584
Affinity Capture-MS Homo sapiens
46 HADHA 3030
Affinity Capture-MS Homo sapiens
47 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CSE1L 1434
Affinity Capture-MS Homo sapiens
49 EPRS 2058
Affinity Capture-MS Homo sapiens
50 RBBP4 5928
Affinity Capture-MS Homo sapiens
51 STRAP 11171
Affinity Capture-MS Homo sapiens
52 PRMT5 10419
Affinity Capture-MS Homo sapiens
53 Cbx5  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
54 NME1 4830
Affinity Capture-MS Homo sapiens
55 HSPA1A 3303
Affinity Capture-MS Homo sapiens
56 TBL1X 6907
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
57 HSPA4 3308
Affinity Capture-MS Homo sapiens
58 PSMC5 5705
Affinity Capture-MS Homo sapiens
59 SMC1A 8243
Affinity Capture-MS Homo sapiens
60 PPP2CB 5516
Affinity Capture-MS Homo sapiens
61 FASN 2194
Affinity Capture-MS Homo sapiens
62 SIK2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
63 RBM25 58517
Affinity Capture-MS Homo sapiens
64 RUVBL2 10856
Affinity Capture-MS Homo sapiens
65 PCMT1 5110
Affinity Capture-MS Homo sapiens
66 PRKAB1 5564
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
67 TKT 7086
Affinity Capture-MS Homo sapiens
68 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
69 MEF2D  
Affinity Capture-Western Homo sapiens
70 TARS 6897
Affinity Capture-MS Homo sapiens
71 OAT 4942
Affinity Capture-MS Homo sapiens
72 DDX3X 1654
Affinity Capture-MS Homo sapiens
73 HNRNPL 3191
Affinity Capture-MS Homo sapiens
74 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
75 NRIP1 8204
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
76 PSMC4 5704
Affinity Capture-MS Homo sapiens
77 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
78 PSMD3 5709
Affinity Capture-MS Homo sapiens
79 LDHA 3939
Affinity Capture-MS Homo sapiens
80 MCM3 4172
Affinity Capture-MS Homo sapiens
81 PRKAA1 5562
Biochemical Activity Homo sapiens
82 HR  
Affinity Capture-Western Homo sapiens
83 NFKBIE  
Reconstituted Complex Homo sapiens
84 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
85 EIF4A1 1973
Affinity Capture-MS Homo sapiens
86 CAND1 55832
Affinity Capture-MS Homo sapiens
87 CAMTA2  
Affinity Capture-Western Homo sapiens
88 RPS3 6188
Affinity Capture-MS Homo sapiens
89 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
90 KIF13B 23303
Affinity Capture-MS Homo sapiens
91 NCOR1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
92 PGK1 5230
Affinity Capture-MS Homo sapiens
93 MTHFD1 4522
Affinity Capture-MS Homo sapiens
94 NPM1 4869
Affinity Capture-MS Homo sapiens
95 NUP93 9688
Affinity Capture-MS Homo sapiens
96 GCM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 HIST4H4 121504
Affinity Capture-MS Homo sapiens
98 ACLY 47
Affinity Capture-MS Homo sapiens
99 KLF4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
100 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PHB 5245
Affinity Capture-MS Homo sapiens
102 USP7 7874
Affinity Capture-MS Homo sapiens
103 TRAP1 10131
Affinity Capture-MS Homo sapiens
104 DYRK1B  
Biochemical Activity Homo sapiens
105 HOXC11  
Two-hybrid Homo sapiens
106 CCT2 10576
Affinity Capture-MS Homo sapiens
107 CAMK2A 815
Affinity Capture-Western Homo sapiens
108 PRPF8 10594
Affinity Capture-MS Homo sapiens
109 RPL4 6124
Affinity Capture-MS Homo sapiens
110 ZBTB16  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
111 NCOR2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
112 JDP2  
Reconstituted Complex Homo sapiens
113 SNRNP200 23020
Affinity Capture-MS Homo sapiens
114 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
115 NR2E1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 PPP2CA 5515
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
117 PKN1 5585
Biochemical Activity Homo sapiens
118 BCL6  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
119 PSMA5 5686
Affinity Capture-MS Homo sapiens
120 IARS 3376
Affinity Capture-MS Homo sapiens
121 KCTD3  
Affinity Capture-MS Homo sapiens
122 GPS2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
123 RPLP0 6175
Affinity Capture-MS Homo sapiens
124 HNRNPD 3184
Affinity Capture-MS Homo sapiens
125 TUBB 203068
Affinity Capture-MS Homo sapiens
126 RPN2 6185
Affinity Capture-MS Homo sapiens
127 CANX 821
Affinity Capture-MS Homo sapiens
128 XPO1 7514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 IKZF3  
Affinity Capture-Western Homo sapiens
130 TUBB4B 10383
Affinity Capture-MS Homo sapiens
131 HSD17B10 3028
Affinity Capture-MS Homo sapiens
132 CIITA  
Affinity Capture-Western Homo sapiens
133 IKZF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 HIST3H3 8290
Affinity Capture-MS Homo sapiens
135 PRKD3 23683
Affinity Capture-MS Homo sapiens
136 EFTUD2 9343
Affinity Capture-MS Homo sapiens
137 CEP250 11190
Affinity Capture-MS Homo sapiens
138 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
139 MYEF2 50804
Affinity Capture-Western Homo sapiens
140 DDB1 1642
Affinity Capture-MS Homo sapiens
141 ADAR 103
Affinity Capture-MS Homo sapiens
142 PHGDH 26227
Affinity Capture-MS Homo sapiens
143 LARS 51520
Affinity Capture-MS Homo sapiens
144 RPL13 6137
Affinity Capture-MS Homo sapiens
145 RBM14 10432
Affinity Capture-MS Homo sapiens
146 CS 1431
Affinity Capture-MS Homo sapiens
147 EIF3F 8665
Affinity Capture-MS Homo sapiens
148 GOT2 2806
Affinity Capture-MS Homo sapiens
149 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
150 PARP1 142
Affinity Capture-MS Homo sapiens
151 ILF3 3609
Affinity Capture-MS Homo sapiens
152 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 H3F3A 3020
Affinity Capture-MS Homo sapiens
154 TP53 7157
Affinity Capture-MS Homo sapiens
155 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
156 FXR1 8087
Affinity Capture-MS Homo sapiens
157 PTBP1 5725
Affinity Capture-MS Homo sapiens
158 SHMT2 6472
Affinity Capture-MS Homo sapiens
159 CDK1 983
Affinity Capture-MS Homo sapiens
160 RAD50 10111
Affinity Capture-MS Homo sapiens
161 ESR1  
Reconstituted Complex Homo sapiens
162 TFE3  
Affinity Capture-Western Homo sapiens
163 Ywhae 29753
Affinity Capture-Western Rattus norvegicus
164 RPL7A 6130
Affinity Capture-MS Homo sapiens
165 ATP1A1 476
Affinity Capture-MS Homo sapiens
166 C1QBP 708
Affinity Capture-MS Homo sapiens
167 PSMD1 5707
Affinity Capture-MS Homo sapiens
168 PRMT1 3276
Affinity Capture-MS Homo sapiens
169 GATA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
170 MCM7 4176
Affinity Capture-MS Homo sapiens
171 MAFF 23764
Two-hybrid Homo sapiens
172 EEF1G 1937
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
173 KSR1  
Affinity Capture-MS Homo sapiens
174 PRKCD 5580
Biochemical Activity Homo sapiens
175 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
176 GATA2  
Affinity Capture-Western Homo sapiens
177 SMC3 9126
Affinity Capture-MS Homo sapiens
178 HNRNPR 10236
Affinity Capture-MS Homo sapiens
179 CBY1  
Affinity Capture-MS Homo sapiens
180 SOX9  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 LRPPRC 10128
Affinity Capture-MS Homo sapiens
182 RPL10A 4736
Affinity Capture-MS Homo sapiens
183 RUVBL1 8607
Affinity Capture-MS Homo sapiens
184 TRIM28 10155
Affinity Capture-MS Homo sapiens
185 MAP1B 4131
Affinity Capture-MS Homo sapiens
186 MCM2 4171
Affinity Capture-MS Homo sapiens
187 RFXANK  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
188 COPB2 9276
Affinity Capture-MS Homo sapiens
189 Cbx3 12417
Reconstituted Complex Mus musculus
190 EIF3B 8662
Affinity Capture-MS Homo sapiens
191 MEF2A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
192 SUV39H1  
Affinity Capture-Western Homo sapiens
193 MCM6 4175
Affinity Capture-MS Homo sapiens
194 TFEB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
195 BCORL1  
Affinity Capture-Western Homo sapiens
196 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
197 PDIA6 10130
Affinity Capture-MS Homo sapiens
198 PRDX4 10549
Affinity Capture-MS Homo sapiens
199 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
200 PKN2 5586
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
201 ANKRA2  
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
202 MDH2 4191
Affinity Capture-MS Homo sapiens
203 IRS4 8471
Affinity Capture-MS Homo sapiens
204 ATP5A1 498
Affinity Capture-MS Homo sapiens
205 RPL9 6133
Affinity Capture-MS Homo sapiens
206 MARS 4141
Affinity Capture-MS Homo sapiens
207 TUBA1A 7846
Affinity Capture-MS Homo sapiens
208 NOP2 4839
Affinity Capture-MS Homo sapiens
209 RPL5 6125
Affinity Capture-MS Homo sapiens
210 DDX20 11218
Affinity Capture-MS Homo sapiens
211 RAN 5901
Affinity Capture-MS Homo sapiens
212 TPI1 7167
Affinity Capture-MS Homo sapiens
213 TAB2  
Reconstituted Complex Homo sapiens
214 DNAJA1 3301
Affinity Capture-MS Homo sapiens
215 RPN1 6184
Affinity Capture-MS Homo sapiens
216 DHX9 1660
Affinity Capture-MS Homo sapiens
217 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
218 NUDC 10726
Affinity Capture-MS Homo sapiens
219 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
220 HDAC5 10014
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
221 CAMK1 8536
Affinity Capture-Western Homo sapiens
222 PCBP2 5094
Affinity Capture-MS Homo sapiens
223 Ahrr  
Affinity Capture-Western Mus musculus
224 AHRR 57491
Affinity Capture-Western Homo sapiens
225 PA2G4 5036
Affinity Capture-MS Homo sapiens
226 ECH1 1891
Affinity Capture-MS Homo sapiens
227 SF3B2 10992
Affinity Capture-MS Homo sapiens
228 ACAT1 38
Affinity Capture-MS Homo sapiens
229 AHCY 191
Affinity Capture-MS Homo sapiens
230 SIK3 23387
Biochemical Activity Homo sapiens
231 MARK3 4140
Affinity Capture-Western Homo sapiens