Gene description for NFATC1
Gene name nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene symbol NFATC1
Other names/aliases NF-ATC
NFAT2
NFATc
Species Homo sapiens
 Database cross references - NFATC1
ExoCarta ExoCarta_4772
Entrez Gene 4772
HGNC 7775
MIM 600489
UniProt O95644  
 NFATC1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for NFATC1
Molecular Function
    FK506 binding GO:0005528 TAS
    protein binding GO:0005515 IPI
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 ISS
    RNA polymerase II transcription factor binding GO:0001085 ISS
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 ISS
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 ISS
    transcription regulatory region DNA binding GO:0044212 IDA
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    mitogen-activated protein kinase p38 binding GO:0048273 ISS
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    intracellular signal transduction GO:0035556 IDA
    G1/S transition of mitotic cell cycle GO:0000082 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    calcium ion transport GO:0006816 IEA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    epithelial to mesenchymal transition GO:0001837 IEA
    heart development GO:0007507 IEA
    osteoclast differentiation GO:0030316 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    innate immune response GO:0045087 TAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    nuclear chromatin GO:0000790 IDA
    transcription factor complex GO:0005667 IEA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified NFATC1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for NFATC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIM1  
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which NFATC1 is involved
PathwayEvidenceSource
Ca2+ pathway TAS Reactome
CLEC7A (Dectin-1) induces NFAT activation TAS Reactome
FCERI mediated Ca+2 mobilization TAS Reactome





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