Gene description for JUND
Gene name jun D proto-oncogene
Gene symbol JUND
Other names/aliases AP-1
Species Homo sapiens
 Database cross references - JUND
ExoCarta ExoCarta_3727
Vesiclepedia VP_3727
Entrez Gene 3727
HGNC 6206
MIM 165162
UniProt P17535  
 JUND identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Hepatocytes 26054723    
 Gene ontology annotations for JUND
Molecular Function
    enzyme binding GO:0019899 IPI
    transcription factor binding GO:0008134 IBA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IBA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    protein binding GO:0005515 IPI
    double-stranded DNA binding GO:0003690 IEA
    transcription regulatory region DNA binding GO:0044212 IDA
    transcription coactivator activity GO:0003713 IBA
    ligand-dependent nuclear receptor binding GO:0016922 IEA
Biological Process
    cellular response to hormone stimulus GO:0032870 IBA
    response to cytokine GO:0034097 IBA
    osteoblast development GO:0002076 IEA
    response to light stimulus GO:0009416 IEA
    response to radiation GO:0009314 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    positive regulation of osteoblast differentiation GO:0045669 IEA
    response to mechanical stimulus GO:0009612 IBA
    cellular response to calcium ion GO:0071277 IEA
    response to drug GO:0042493 IBA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    regulation of cell cycle GO:0051726 IBA
    circadian rhythm GO:0007623 IEA
    positive regulation of cell differentiation GO:0045597 IBA
    response to cAMP GO:0051591 IBA
    regulation of cell proliferation GO:0042127 IBA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    response to lipopolysaccharide GO:0032496 IBA
    response to peptide hormone GO:0043434 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    aging GO:0007568 IEA
    regulation of cell death GO:0010941 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nuclear chromatin GO:0000790 IBA
    chromatin GO:0000785 TAS
    nucleus GO:0005634 IDA
    transcription factor complex GO:0005667 IBA
 Experiment description of studies that identified JUND in exosomes
1
Experiment ID 226
MISEV standards
EM
EV Biophysical techniques
GAPDH|CD9|FLOT1
EV Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for JUND
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOS 2353
Invitro Homo sapiens
2 NFE2L2 4780
Invivo Homo sapiens
3 BCL6  
Invivo Homo sapiens
Invitro Homo sapiens
4 MEN1 4221
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 COPS5 10987
Co-localization Homo sapiens
6 BRCA1 672
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 DDIT3 1649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 MAPK8 5599
Reconstituted Complex Homo sapiens
9 BATF  
Invitro Homo sapiens
Two-hybrid Homo sapiens
10 SMAD4  
Invitro Homo sapiens
11 ATF3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 MAPK9 5601
Invitro Homo sapiens
13 NFE2L1  
Invivo Homo sapiens
Invitro Homo sapiens
14 RFWD2  
Affinity Capture-Western Homo sapiens
15 FOSL2  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which JUND is involved
No pathways found





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