Gene description for DDIT3
Gene name	DNA-damage-inducible transcript 3
Gene symbol	DDIT3
Other names/aliases	CEBPZ CHOP CHOP-10 CHOP10 GADD153
Species	Homo sapiens
Database cross references - DDIT3
ExoCarta	ExoCarta_1649
Entrez Gene	1649
HGNC	2726
MIM	126337
UniProt	P35638
DDIT3 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for DDIT3

Molecular Function     protein homodimerization activity GO:0042803 ISS     transcription regulatory region sequence-specific DNA binding GO:0000976 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     leucine zipper domain binding GO:0043522 IDA     protein binding GO:0005515 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA     transcription corepressor activity GO:0003714 TAS     transcription regulatory region DNA binding GO:0044212 ISS     transcription factor binding GO:0008134 IPI     protein heterodimerization activity GO:0046982 TAS     DNA binding GO:0003677 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 IGI     cAMP response element binding protein binding GO:0008140 IPI Biological Process     ER overload response GO:0006983 IEA     intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA     Wnt signaling pathway GO:0016055 IEA     cellular protein metabolic process GO:0044267 TAS     regulation of transcription, DNA-templated GO:0006355 IMP     mRNA transcription from RNA polymerase II promoter GO:0042789 IDA     response to starvation GO:0042594 IEA     response to endoplasmic reticulum stress GO:0034976 IDA     cell cycle arrest GO:0007050 IDA     endoplasmic reticulum unfolded protein response GO:0030968 TAS     regulation of transcription involved in anterior/posterior axis specification GO:0044324 ISS     positive regulation of interleukin-8 production GO:0032757 IMP     positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902237 IC     release of sequestered calcium ion into cytosol GO:0051209 IEA     negative regulation of myoblast differentiation GO:0045662 IEA     negative regulation of transcription, DNA-templated GO:0045892 IDA     cellular response to DNA damage stimulus GO:0006974 TAS     negative regulation of determination of dorsal identity GO:2000016 IDA     positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 ISS     positive regulation of transcription, DNA-templated GO:0045893 IDA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     ATF6-mediated unfolded protein response GO:0036500 TAS     response to unfolded protein GO:0006986 IDA     negative regulation of protein kinase B signaling GO:0051898 IMP     negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 ISS     blood vessel maturation GO:0001955 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     positive regulation of neuron apoptotic process GO:0043525 IC     PERK-mediated unfolded protein response GO:0036499 TAS     negative regulation of CREB transcription factor activity GO:0032792 IDA     regulation of DNA-templated transcription in response to stress GO:0043620 TAS     cell redox homeostasis GO:0045454 IDA Subcellular Localization     CHOP-ATF3 complex GO:1990622 IDA     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA     protein-DNA complex GO:0032993 IDA     AP1 complex GO:0035976 ISS     CHOP-C/EBP complex GO:0036488 TAS     late endosome GO:0005770 IEA     CHOP-ATF4 complex GO:1990617 IPI