Gene description for SRA1
Gene name steroid receptor RNA activator 1
Gene symbol SRA1
Other names/aliases SRA
SRAP
STRAA1
pp7684
Species Homo sapiens
 Database cross references - SRA1
ExoCarta ExoCarta_10011
Vesiclepedia VP_10011
Entrez Gene 10011
HGNC 11281
MIM 603819
UniProt Q9HD15  
 SRA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SRA1
Molecular Function
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 IBA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 IDA
Biological Process
    apoptotic process GO:0006915 IEA
    regulation of apoptotic process GO:0042981 IDA
    positive regulation of receptor activity GO:2000273 IBA
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    cell proliferation GO:0008283 IDA
    cell differentiation GO:0030154 IDA
Subcellular Localization
    intercellular bridge GO:0045171 IDA
    nucleoplasm GO:0005654 IDA
    ribonucleoprotein complex GO:0030529 IPI
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 IDA
    microtubule cytoskeleton GO:0015630 IDA
 Experiment description of studies that identified SRA1 in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
EV Enriched markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SRA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPEN 23013
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SRA1 is involved
No pathways found





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