Gene description for SEC24D
Gene name SEC24 family member D
Gene symbol SEC24D
Other names/aliases CLCRP2
Species Homo sapiens
 Database cross references - SEC24D
ExoCarta ExoCarta_9871
Entrez Gene 9871
HGNC 10706
MIM 607186
UniProt O94855  
 SEC24D identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for SEC24D
Molecular Function
    protein binding GO:0005515 IPI
    molecular_function GO:0003674 ND
    zinc ion binding GO:0008270 IEA
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    intracellular protein transport GO:0006886 IEA
    membrane organization GO:0061024 TAS
    small molecule metabolic process GO:0044281 TAS
    post-translational protein modification GO:0043687 TAS
    COPII vesicle coating GO:0048208 TAS
    in utero embryonic development GO:0001701 IEA
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    ER to Golgi vesicle-mediated transport GO:0006888 TAS
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
Subcellular Localization
    COPII vesicle coat GO:0030127 NAS
    perinuclear region of cytoplasm GO:0048471 IEA
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 TAS
    Golgi membrane GO:0000139 IEA
 Experiment description of studies that identified SEC24D in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEC24D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC23B 10483
Two-hybrid Homo sapiens
View the network image/svg+xml



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