Gene description for EWSR1
Gene name EWS RNA-binding protein 1
Gene symbol EWSR1
Other names/aliases EWS
bK984G1.4
Species Homo sapiens
 Database cross references - EWSR1
ExoCarta ExoCarta_2130
Entrez Gene 2130
HGNC 3508
MIM 133450
UniProt Q01844  
 EWSR1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for EWSR1
Molecular Function
    protein binding GO:0005515 IPI
    RNA binding GO:0003723 TAS
    identical protein binding GO:0042802 IPI
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
    zinc ion binding GO:0008270 IEA
    calmodulin binding GO:0005516 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified EWSR1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for EWSR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALYL 138046
Two-hybrid Homo sapiens
2 NLE1  
Two-hybrid Homo sapiens
3 AGT 183
Two-hybrid Homo sapiens
4 C1orf71  
Two-hybrid Homo sapiens
5 CUEDC2  
Two-hybrid Homo sapiens
6 MATK  
Two-hybrid Homo sapiens
7 WWP1 11059
Two-hybrid Homo sapiens
8 RAB37 326624
Two-hybrid Homo sapiens
9 MYO1F 4542
Two-hybrid Homo sapiens
10 KIAA0980  
Two-hybrid Homo sapiens
11 ELAVL4  
Two-hybrid Homo sapiens
12 MDFI  
Two-hybrid Homo sapiens
13 RAD23A  
Two-hybrid Homo sapiens
14 BNIP3L  
Two-hybrid Homo sapiens
15 KEL  
Two-hybrid Homo sapiens
16 MVK 4598
Two-hybrid Homo sapiens
17 DNAJB3 414061
Two-hybrid Homo sapiens
18 ARHGDIA 396
Affinity Capture-MS Homo sapiens
19 AE2  
Two-hybrid Homo sapiens
20 ELAVL3  
Two-hybrid Homo sapiens
21 RASL11B  
Two-hybrid Homo sapiens
22 CPSF7 79869
Two-hybrid Homo sapiens
23 TULP2  
Two-hybrid Homo sapiens
24 TRPV5  
Two-hybrid Homo sapiens
25 HMGA1 3159
Two-hybrid Homo sapiens
26 NSUN4  
Two-hybrid Homo sapiens
27 EPT1 85465
Two-hybrid Homo sapiens
28 PDHX  
Two-hybrid Homo sapiens
29 YY1AP1 55249
Two-hybrid Homo sapiens
30 FLJ36766  
Two-hybrid Homo sapiens
31 NDUFV1  
Two-hybrid Homo sapiens
32 GSK3B 2932
Affinity Capture-MS Homo sapiens
33 MYL6 4637
Two-hybrid Homo sapiens
34 DMRTB1  
Two-hybrid Homo sapiens
35 NDUFB1 4707
Two-hybrid Homo sapiens
36 ZDHHC3  
Two-hybrid Homo sapiens
37 MGC34821  
Two-hybrid Homo sapiens
38 C10orf12  
Two-hybrid Homo sapiens
39 PLSCR1 5359
Two-hybrid Homo sapiens
40 KHDRBS2  
Two-hybrid Homo sapiens
41 CXADR 1525
Two-hybrid Homo sapiens
42 MSC  
Two-hybrid Homo sapiens
43 TSPAN3 10099
Two-hybrid Homo sapiens
44 SNRPC  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
45 CFDP1  
Two-hybrid Homo sapiens
46 SP192  
Two-hybrid Homo sapiens
47 BARD1 580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
48 RPL31 6160
Two-hybrid Homo sapiens
49 ACTL6A 86
Two-hybrid Homo sapiens
50 KRIT1 889
Invitro Homo sapiens
51 CETP 1071
Two-hybrid Homo sapiens
52 PTK2B 2185
Invivo Homo sapiens
Invitro Homo sapiens
53 MRPS18B  
Two-hybrid Homo sapiens
54 BTK 695
Affinity Capture-Western Homo sapiens
55 DYNLL2 140735
Two-hybrid Homo sapiens
56 FLJ11088  
Two-hybrid Homo sapiens
57 RPS15A 6210
Two-hybrid Homo sapiens
58 PRTFDC1  
Two-hybrid Homo sapiens
59 HERPUD1  
Two-hybrid Homo sapiens
60 PEPP-2  
Two-hybrid Homo sapiens
61 C18orf10  
Two-hybrid Homo sapiens
62 PGLS 25796
Two-hybrid Homo sapiens
63 SMAD1  
Affinity Capture-MS Homo sapiens
64 MGC11271  
Two-hybrid Homo sapiens
65 MAGEA11  
Two-hybrid Homo sapiens
66 CD2BP2 10421
Affinity Capture-MS Homo sapiens
67 LILRA3  
Two-hybrid Homo sapiens
68 SF1 7536
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
69 WDR37 22884
Two-hybrid Homo sapiens
70 C13orf21  
Two-hybrid Homo sapiens
71 ELK1  
Reconstituted Complex Homo sapiens
72 MTMR9  
Two-hybrid Homo sapiens
73 SUV39H2 79723
Two-hybrid Homo sapiens
74 MNS1  
Two-hybrid Homo sapiens
75 KRR1 11103
Two-hybrid Homo sapiens
76 DFFA  
Two-hybrid Homo sapiens
77 ILK 3611
Affinity Capture-MS Homo sapiens
78 TCFL1  
Two-hybrid Homo sapiens
79 TMSB4Y  
Two-hybrid Homo sapiens
80 GNPDA1 10007
Two-hybrid Homo sapiens
81 MAPK1IP1L 93487
Two-hybrid Homo sapiens
82 SALL2  
Two-hybrid Homo sapiens
83 FASN 2194
Two-hybrid Homo sapiens
84 MGC2749  
Two-hybrid Homo sapiens
85 BAD  
Two-hybrid Homo sapiens
86 CPSF6 11052
Two-hybrid Homo sapiens
87 RNF183  
Two-hybrid Homo sapiens
88 RBPMS  
Two-hybrid Homo sapiens
89 SMNDC1  
Affinity Capture-MS Homo sapiens
90 SMAD4  
Two-hybrid Homo sapiens
91 MYOZ2 51778
Two-hybrid Homo sapiens
92 SSBP2  
Two-hybrid Homo sapiens
93 CREBBP  
Reconstituted Complex Homo sapiens
94 POU4F1  
Two-hybrid Homo sapiens
95 PUF60 22827
Affinity Capture-MS Homo sapiens
96 NPPB  
Two-hybrid Homo sapiens
97 NTNG2  
Two-hybrid Homo sapiens
98 WWP2 11060
Two-hybrid Homo sapiens
99 TRIM37  
Two-hybrid Homo sapiens
100 CCDC7  
Two-hybrid Homo sapiens
101 C11orf16  
Two-hybrid Homo sapiens
102 MTCP1  
Two-hybrid Homo sapiens
103 PRV1  
Two-hybrid Homo sapiens
104 PRUNE2  
Two-hybrid Homo sapiens
105 CEACAM5 1048
Two-hybrid Homo sapiens
106 FLJ22318  
Two-hybrid Homo sapiens
107 SLC1A1 6505
Two-hybrid Homo sapiens
108 KCNMB1  
Two-hybrid Homo sapiens
109 ZNF165  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which EWSR1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here