Gene description for HNRNPUL1
Gene name heterogeneous nuclear ribonucleoprotein U-like 1
Gene symbol HNRNPUL1
Other names/aliases E1B-AP5
E1BAP5
HNRPUL1
Species Homo sapiens
 Database cross references - HNRNPUL1
ExoCarta ExoCarta_11100
Entrez Gene 11100
HGNC 17011
MIM 605800
UniProt Q9BUJ2  
 HNRNPUL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Thymus 23844026    
 Gene ontology annotations for HNRNPUL1
Molecular Function
    RNA binding GO:0003723 TAS
    poly(A) RNA binding GO:0044822 IDA
    enzyme binding GO:0019899 IPI
    protein binding GO:0005515 IPI
Biological Process
    mRNA splicing, via spliceosome GO:0000398 TAS
    response to virus GO:0009615 IEA
    RNA processing GO:0006396 TAS
    transcription, DNA-templated GO:0006351 IEA
    RNA splicing GO:0008380 TAS
    gene expression GO:0010467 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    ribonucleoprotein complex GO:0030529 IEA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified HNRNPUL1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HNRNPUL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MED31  
Two-hybrid Homo sapiens
2 ZNF9  
Affinity Capture-MS Homo sapiens
3 PAF53  
Affinity Capture-MS Homo sapiens
4 BRD7  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 HRMT1L1  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 C14orf1 11161
Two-hybrid Homo sapiens
7 PRPF40A 55660
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
8 CRMP1 1400
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HNRNPUL1 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome





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