Gene description for STAT3
Gene name	signal transducer and activator of transcription 3 (acute-phase response factor)
Gene symbol	STAT3
Other names/aliases	ADMIO APRF HIES
Species	Homo sapiens
Database cross references - STAT3
ExoCarta	ExoCarta_6774
Entrez Gene	6774
HGNC	11364
MIM	102582
UniProt	P40763
STAT3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for STAT3

Molecular Function     signal transducer activity GO:0004871 IEA     protein binding GO:0005515 IPI     transcription factor binding GO:0008134 IPI     ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IDA     protein phosphatase binding GO:0019903 IPI     glucocorticoid receptor binding GO:0035259 IEA     DNA binding GO:0003677 ISS     CCR5 chemokine receptor binding GO:0031730 IEA     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     transcription regulatory region DNA binding GO:0044212 IDA     RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA     protein dimerization activity GO:0046983 ISS     protein kinase binding GO:0019901 ISS     RNA polymerase II repressing transcription factor binding GO:0001103 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA Biological Process     nervous system development GO:0007399 TAS     acute-phase response GO:0006953 IEA     eating behavior GO:0042755 ISS     growth hormone receptor signaling pathway GO:0060396 IDA     positive regulation of Notch signaling pathway GO:0045747 ISS     negative regulation of cell proliferation GO:0008285 IEA     response to drug GO:0042493 IEA     positive regulation of transcription, DNA-templated GO:0045893 ISS     interleukin-6-mediated signaling pathway GO:0070102 IMP     astrocyte differentiation GO:0048708 ISS     signal transduction GO:0007165 TAS     cellular response to hormone stimulus GO:0032870 IDA     viral process GO:0016032 IEA     protein import into nucleus GO:0006606 IDA     regulation of transcription, DNA-templated GO:0006355 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     negative regulation of glycolytic process GO:0045820 IEA     negative regulation of apoptotic process GO:0043066 IMP     sexual reproduction GO:0019953 ISS     transcription from RNA polymerase II promoter GO:0006366 IEA     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     cytokine-mediated signaling pathway GO:0019221 NAS     intracellular receptor signaling pathway GO:0030522 IDA     regulation of multicellular organism growth GO:0040014 IEA     temperature homeostasis GO:0001659 ISS     radial glial cell differentiation GO:0060019 ISS     regulation of transcription from RNA polymerase II promoter GO:0006357 ISS     response to estradiol GO:0032355 IDA     cell proliferation GO:0008283 IEA     phosphorylation GO:0016310 ISS     response to ethanol GO:0045471 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     eye photoreceptor cell differentiation GO:0001754 ISS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     negative regulation of neuron migration GO:2001223 IEA     JAK-STAT cascade GO:0007259 TAS     movement of cell or subcellular component GO:0006928 TAS     glucose homeostasis GO:0042593 ISS     somatic stem cell maintenance GO:0035019 TAS Subcellular Localization     plasma membrane GO:0005886 ISS     cytoplasm GO:0005737 ISS     RNA polymerase II transcription factor complex GO:0090575 IC     cytosol GO:0005829 TAS     nucleus GO:0005634 ISS     nuclear chromatin GO:0000790 IDA     nucleoplasm GO:0005654 TAS     mitochondrial inner membrane GO:0005743 IEA