Gene ontology annotations for STAT3
Experiment description of studies that identified STAT3 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
231
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
5
Experiment ID
232
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
6
Experiment ID
233
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
7
Experiment ID
191
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
20124223
Organism
Homo sapiens
Experiment description
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors
Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name
Mol Cell Proteomics
Publication year
2010
Sample
Squamous carcinoma cells
Sample name
Squamous carcinoma cell (A431)
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
8
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for STAT3
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
HTATIP
Affinity Capture-Western
Homo sapiens
2
PTPN11
5781
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
LEP
Reconstituted Complex
Homo sapiens
4
ERBB2
2064
Affinity Capture-Western
Homo sapiens
5
TCF1
Invivo
Homo sapiens
6
NMI
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
7
NCOA1
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
8
GTF2I
2969
Invivo
Homo sapiens
Invitro
Homo sapiens
9
CCND1
595
Affinity Capture-Western
Homo sapiens
10
TSHR
7253
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
11
RPA2
6118
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
12
EIF2AK2
5610
Invivo
Homo sapiens
13
JUN
3725
Invivo
Homo sapiens
Invitro
Homo sapiens
14
LCK
3932
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
15
PDIA3
2923
Invitro
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
16
SMAD1
Affinity Capture-Western
Homo sapiens
17
NR3C1
2908
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
18
EPHA5
2044
Affinity Capture-Western
Homo sapiens
19
RELA
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
20
EGFR
1956
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
21
PTPN2
5771
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
22
CDKN1A
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
23
RET
5979
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
24
HSP90AA1
3320
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
25
GRIM19
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
26
MYOD1
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
27
ESR1
Affinity Capture-Western
Homo sapiens
28
CREBBP
Affinity Capture-Western
Homo sapiens
29
NFKB1
4790
Invivo
Homo sapiens
Invitro
Homo sapiens
30
JAK3
3718
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
31
IL6ST
3572
Invivo
Homo sapiens
32
ELP2
55250
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
Two-hybrid
Homo sapiens
33
STAT1
6772
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-Western
Homo sapiens
34
IFNAR1
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
35
JAK1
3716
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
36
PML
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
37
LEPR
3953
Invivo
Homo sapiens
38
MTOR
2475
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
39
FES
2242
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
40
TRIP10
9322
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
41
MET
4233
Invivo
Homo sapiens
42
IL2RB
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
43
GHR
Invivo
Homo sapiens
44
SRC
6714
Invitro
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
45
AR
367
Invivo
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
46
SYK
6850
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
47
RAC1
5879
Invivo
Homo sapiens
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
48
PIAS3
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
49
IL1RAP
3556
Affinity Capture-Western
Homo sapiens
50
BMX
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
51
JAK2
3717
Invivo
Homo sapiens
52
IL6R
Invivo
Homo sapiens
53
TSLP
Invivo
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
54
EP300
2033
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
55
KHDRBS1
10657
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which STAT3 is involved