Gene description for TMEM206
Gene name transmembrane protein 206
Gene symbol TMEM206
Other names/aliases C1orf75
Species Homo sapiens
 Database cross references - TMEM206
ExoCarta ExoCarta_55248
Vesiclepedia VP_55248
Entrez Gene 55248
HGNC 25593
UniProt Q9H813  
 TMEM206 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM206
Molecular Function
    protein binding GO:0005515 IPI
    pH-gated chloride channel activity GO:0061797 IDA
Biological Process
    chloride transport GO:0006821 IDA
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 HDA
    chloride channel complex GO:0034707 IEA
 Experiment description of studies that identified TMEM206 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM206
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM73A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CHRNA4  
Affinity Capture-MS Homo sapiens
3 WDR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SACM1L 22908
Affinity Capture-MS Homo sapiens
5 TTYH3 80727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NRSN1  
Affinity Capture-MS Homo sapiens
7 NOP9 161424
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 EIF2B2 8892
Affinity Capture-MS Homo sapiens
10 TMEM147 10430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ATP12A 479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RAB9B 51209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CSE1L 1434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GHDC  
Affinity Capture-MS Homo sapiens
15 PWP2 5822
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 NUP160 23279
Affinity Capture-MS Homo sapiens
17 PDE2A  
Affinity Capture-MS Homo sapiens
18 HCCS 3052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 QSOX2 169714
Affinity Capture-MS Homo sapiens
20 HEATR3 55027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RINT1 60561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM222 84065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 STX7 8417
Affinity Capture-MS Homo sapiens
25 STAT3 6774
Affinity Capture-MS Homo sapiens
26 ARMCX3 51566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 XPO7 23039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TBC1D15 64786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CARKD 55739
Affinity Capture-MS Homo sapiens
30 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ATP1A3 478
Affinity Capture-MS Homo sapiens
33 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NUP155 9631
Affinity Capture-MS Homo sapiens
35 ENPP6 133121
Affinity Capture-MS Homo sapiens
36 HTR3C  
Affinity Capture-MS Homo sapiens
37 IPO11 51194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 IPO7 10527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TNPO1 3842
Affinity Capture-MS Homo sapiens
40 DEGS1  
Affinity Capture-MS Homo sapiens
41 EIF2B5 8893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 DCUN1D5 84259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CHRNB2  
Affinity Capture-MS Homo sapiens
44 RAP1B 5908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PBXIP1 57326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CKAP5 9793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TBRG4 9238
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GNA13 10672
Affinity Capture-MS Homo sapiens
49 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ATP2C1 27032
Affinity Capture-MS Homo sapiens
51 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 BZW1 9689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 COMMD3 23412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 EIF2B4 8890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ARFGAP1 55738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 IPO9 55705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SGPL1 8879
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 RDH14 57665
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CANX 821
Affinity Capture-MS Homo sapiens
60 GNB4 59345
Affinity Capture-MS Homo sapiens
61 KIAA1244  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 GLMN 11146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 MCOLN3  
Affinity Capture-MS Homo sapiens
64 MZT2B 80097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 VAMP3 9341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 DAB2IP 153090
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 GPD2 2820
Affinity Capture-MS Homo sapiens
68 TNPO3 23534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 GBF1 8729
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 EIF2B3 8891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 PI4K2A 55361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SAAL1 113174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 XPO4 64328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 A4GNT  
Affinity Capture-MS Homo sapiens
75 GNB2 2783
Affinity Capture-MS Homo sapiens
76 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 MTOR 2475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 MPZL1 9019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 MMS22L  
Affinity Capture-MS Homo sapiens
80 RABGAP1 23637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 DDRGK1 65992
Affinity Capture-MS Homo sapiens
82 THADA 63892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 FAM114A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 NCAPG 64151
Affinity Capture-MS Homo sapiens
85 TSPAN5 10098
Affinity Capture-MS Homo sapiens
86 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 GLRA2  
Affinity Capture-MS Homo sapiens
88 KNTC1 9735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TMEM68  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 RRP1 8568
Affinity Capture-MS Homo sapiens
93 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 C19orf25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 VAC14 55697
Affinity Capture-MS Homo sapiens
96 STAG1  
Affinity Capture-MS Homo sapiens
97 UFL1 23376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 USP30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 NRAS 4893
Affinity Capture-MS Homo sapiens
100 ERICH5  
Affinity Capture-MS Homo sapiens
101 TMEM38B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ASPHD2  
Affinity Capture-MS Homo sapiens
104 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ZACN  
Affinity Capture-MS Homo sapiens
106 PRAF2 11230
Affinity Capture-MS Homo sapiens
107 HLA-C 3107
Affinity Capture-MS Homo sapiens
108 ZWILCH 55055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 PCYT1A 5130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ATP13A1 57130
Affinity Capture-MS Homo sapiens
111 MTCH2 23788
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM206 is involved
No pathways found





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